DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7737 and Smox

DIOPT Version :9

Sequence 1:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001171304.1	Gene:	Smox / 228608	MGIID:	2445356	Length:	585	Species:	Mus musculus

Alignment Length:	590	Identity:	168/590 - (28%)
Similarity:	251/590 - (42%)	Gaps:	118/590 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PGMSGAQRNQDRKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGA 97
            |...|.:|....::||||||.:|:|.|..|||.||.:|.|:||...:|||:.::...|...:|||
Mouse    14 PLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVRLGDTTFELGA 78

  Fly    98 QWCHGERDNIVYELTRKQDEELLESTGPVYENYECVRSNGDV------------------VPEEV 144
            .|.||...|.:|:|.        |:.|.:.|..:..||.|.:                  :|::|
Mouse    79 TWIHGSHGNPIYQLA--------EANGLLEETTDGERSVGRISLYSKNGVACYLTNRGCRIPKDV 135

  Fly   145 SSRLKAIVGDSLVTRQLELRH-------CSGSLGSYLTNKFYDTLR-RPENSDIDAEVASEFFVN 201
            ......:..:.....|...||       ...|:|.:...|..:.:| .|::::....:.......
Mouse   136 VEEFSDLYNEVYNMTQEFFRHGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQ 200

  Fly   202 YQKFENSVEASDTLEQVSGRGYLDYWECEG--DILLNWKDKGYVELLRLLMRSRELNVEHGVLEQ 264
            |.|.|:...:|.::::||...:.::.|..|  .|:    ..|::.::.||        ..|:...
Mouse   201 YLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHII----PSGFMRVVELL--------AEGIPPH 253

  Fly   265 RLLLGTRVVKINW--------------------------------NRNDGR--------VELQMS 289
            .:.||..|..|:|                                |...||        |.::..
Mouse   254 VIQLGKPVRCIHWDQASAHPRGPEIEPRGEGDHNHDTGEGGQSGENPQQGRWDEDEPWPVVVECE 318

  Fly   290 NGETCIADHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTG 354
            :.|...||||:|||||||||.|:...|.|.||.||..||..|..||.:|||:||.|.||..:...
Mouse   319 DCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNS 383

  Fly   355 FTMLWRDE-DLDDIRGTSRAWLEDVFGFYRVSYQP----RILAGWITNESGRHMETLPVDEVQAG 414
            ...:|.|| :...:......|...:.|| .|.|.|    .:|:|||..|....||....:.|...
Mouse   384 LQFVWEDEAESCTLTYPPELWYRKICGF-DVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEI 447

  Fly   415 VMYLFRRFL-RWKIPDPANFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEK 478
            ...:.|:|. ...||.|.....|||.:|..|||||||..:.:.  |....:|:.||....::...
Mouse   448 CTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSS--GADVEKLAKPLPYTESSKTA 510

  Fly   479 DKDSEDEAWQQ------SRCD-----------RPI-VQFAGEASSEHYYSTVHGAVEAGWREARR 525
            .:.|.:   ||      |:|.           :|: |.|:|||:...||||.|||:.:|.|||.|
Mouse   511 HRSSTE---QQPGHLLPSKCPEQSLDPSRGSIKPMQVLFSGEATHRKYYSTTHGALLSGQREAAR 572

  Fly   526 LAQFY 530
            |.:.|
Mouse   573 LIEMY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	27/57 (47%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	156/563 (28%)
Smox	NP_001171304.1	PLN02568	50..578	CDD:215308	151/554 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	1	1.100	-	-	O	PTHR10742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740