DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7737 and hpo-15

DIOPT Version :9

Sequence 1:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_504456.1	Gene:	hpo-15 / 178934	WormBaseID:	WBGene00016061	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	131/512 - (25%)
Similarity:	219/512 - (42%)	Gaps:	89/512 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGAQWCHGERDNIVYE 110
            |.::|||.||::.|.:|:|||..:..:.|..||:|||||.||:.|..:.:|||:.:|.: |.:|:
Worm    34 IAIVGAGISGLSTARRLIELGIDDFDIYEGLDRIGGRIHAIPYKDGFLQMGAQFINGAQ-NPLYK 97

  Fly   111 LTRKQD--EELLESTGPVYENYECVRSNGDVVPEEVSSRLKAIVGDSLVTRQLELRHCSGSLGSY 173
            :..:..  .:::..|..| :|......|.:|..:::.:.|.       .|.:|:.::.|
Worm    98 IANRLGLLADVVSDTAHV-DNAHFAFGNQNVQEKDIKTFLD-------FTSKLDPKYRS------ 148

  Fly   174 LTNKFYDTLRRPENSDIDAEVASEFFVNYQKFENSVEASDTLEQV---SGRGYLDYWECEG---- 231
            :......|.||....:|       |.::|..|..|...:|....|   ..|.:..|||.|.
Worm   149 IAKHDEKTARRYTFKEI-------FTLDYMHFLKSQNFTDQQTNVFDSLARSFRSYWEFEWAADW 206

  Fly   232 -----DILLNWKDK------------GYVELLRLLMRSRELNVEHGVLEQRLLLGTRVVKINWNR 279
                 .:|..|.|.            |:..:|.        ::...:..:.....:||..||.:.
Worm   207 STLSVHVLKEWNDYGPECESFATNKIGFKAILD--------DIAAPIPRKAFNFNSRVENINLDS 263

  Fly   280 NDGRVELQMSNGETCIA-DHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEF 343
            |.|:::|.:|:...... |:::||.||||||..|.::|.|.||.:|..||:.:.||...|:|.|:
Worm   264 NTGKIKLTVSDRAVPTEYDYIIVTSSLGVLKKYHHKMFTPPLPRQKIEAIEKIGFGGSCKVFFEW 328

  Fly   344 PEAFWPEDWTGFTMLWRDEDLDDIRGTSR----AWLEDVFGFYRVSYQPRILAGWITNESGRHME 404
            ...||..:......|       .::|..|    |:.::......|.:.|.:|:.|......:.::
Worm   329 ETPFWSNNTYSIAPL-------PVKGMIRDKLDAFEDETTILQVVDWAPNVLSAWYAGRGHQLVD 386

  Fly   405 TLPVDEVQAGVMYLFRRFLRWK-IPDPANFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHP 468
            .:..:|::..:..|.|.....| ||:|:....:....|:...|||||.        |..:.|||.
Worm   387 NMSEEELKQRITKLMRDMYNDKSIPEPSKIIRTQLTKNELLLGSYSYM--------TQVQALSHI 443

  Fly   469 LTVVATTPEKDKDSEDEAWQQSRCDRPIVQFAGEASSEHYYSTVHGAVEAGWREARR 525
            .......|.|.:            .||.|.|||||:....:.|..|...:|.|||.|
Worm   444 SHSQLAIPVKLE------------GRPKVLFAGEATHHRLFQTTIGGYLSGRREADR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	25/57 (44%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	127/504 (25%)
hpo-15	NP_504456.1	Amino_oxidase	41..488	CDD:366721	126/503 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	1	1.000	-	-		mtm4748
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.720