Protein Alignment Syx7 and STX17

DIOPT Version :9

• Sequence 1: NP_730632.1
• Gene: Syx7 / 36173
• FlyBaseID: FBgn0267849
• Length: 282
• Species: Drosophila melanogaster
• Sequence 2: NP_060389.2
• Gene: STX17 / 55014
• HGNCID: 11432
• Length: 302
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 56/245 - (22%)
• Similarity: 100/245 - (40%)
• Gaps: 62/245 - (25%)

  Fly    29 IIATSIQKV---QQNVSTMQRMVNQLNTPQDSPELKKQLHQIMTYTNQLVTDTNNQINEVDK-CK 89
            :|.|.::::   |.|:...||.           .:..:||:......:.|....:.|.|::| |
Human    24 VIPTDLERLRKHQINIEKYQRC-----------RIWDKLHEEHINAGRTVQQLRSNIREIEKLC- 76

  Fly    90 ERHLKIQRDRLV----------DEFTAALTAFQSVQRKTADIEKTALRQARGDSYNIARPP---- 140
               ||:::|.||          :|.:||...|  :|.....:|:  |::...|...:.:||
Human    77 ---LKVRKDDLVLLKRMIDPVKEEASAATAEF--LQLHLESVEE--LKKQFNDEETLLQPPLTRS 134

  Fly   141 ----GSSRTGSSNSSASQQDNNSFFEDNFFNRKSNQQQMQTQMEEQADLQALEEQEQVIRELENN 201
                |:..|  :.:.||.|               :..|:....|...|..|.|..|    .||.:
Human   135 MTVGGAFHT--TEAEASSQ---------------SLTQIYALPEIPQDQNAAESWE----TLEAD 178

  Fly   202 IVGVNEIYKKLGALVYEQGLTVDSIESQVEQTSIFVSQGTENLRKASSYR 251
            ::.::::......||..|...:|||...|...::.|.:||:||.||:.|:
Human   179 LIELSQLVTDFSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLGKAAKYK 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx7	NP_730632.1	Syntaxin_2	30..126	CDD:291208	24/109 (22%)
		COG5325	<97..276	CDD:227635	41/173 (24%)
		SNARE	188..247	CDD:304603	16/58 (28%)
STX17	NP_060389.2	COG5325	2..228	CDD:227635	55/243 (23%)
		SNARE_syntaxin17	162..223	CDD:277199	18/64 (28%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000269|PubMed:23217709	229..275		56/245 (23%)
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	299..302

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900