Protein Alignment Syx7 and Stx17

DIOPT Version :10

• Sequence 1: NP_730632.1
• Gene: Syx7 / 36173
• FlyBaseID: FBgn0267849
• Length: 282
• Species: Drosophila melanogaster
• Sequence 2: NP_663775.1
• Gene: Stx17 / 252853
• RGDID: 708499
• Length: 301
• Species: Rattus norvegicus
• Alignment Length: 272
• Identity: 63/272 - (23%)
• Similarity: 110/272 - (40%)
• Gaps: 69/272 - (25%)

  Fly    24 QRLAQIIATS----IQKVQQNVSTMQRMVNQLNTPQDSPELKKQLHQIMTYTNQLVTDTNNQINE 84
            |:..:|:..:    ::|.|.|:...||.           .:..:||:......:.|....:.|.|
  Rat    18 QKFTKIVIPTDLERLKKHQINIEKYQRC-----------RIWDKLHEEHINAGRTVQQLRSNIRE 71

  Fly    85 VDK-CKERHLKIQRD------RLVD---EFTAALTA------FQSVQ--RKTADIEKTALRQARG 131
            ::| |    ||:.:|      |::|   |..||.||      .:||:  :|....|:..|:.:..
  Rat    72 MEKLC----LKVHKDDLILLKRMIDPMKEAAAAATAEFLQLHLESVEELKKQVKNEEALLQPSLT 132

  Fly   132 DSYNIARPPGSSRTGSSNSSASQQDNNSFFEDNFFNRKSNQQQMQTQMEEQADLQALEEQEQVIR 196
            .|..|    ....||.: .:|||                :..|:....|...|..|.|..|
  Rat   133 RSTTI----DGVHTGEA-EAASQ----------------SLTQIYALPEIPRDQNAAESWE---- 172

  Fly   197 ELENNIVGVNEIYKKLGALVYEQGLTVDSIESQVEQTSIFVSQGTENLRKASSYRNKVRKKKLIL 261
            .||.:::.::.:...:..||..|...:|||...|...::.|.:||:||:||:.|       ||..
  Rat   173 TLEADLIELSHLVTDMSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKY-------KLAA 230

  Fly   262 VGILSAVLLAII 273
            :.:..||:..::
  Rat   231 LPVAGAVIGGVV 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx7	NP_730632.1	Syntaxin_2	30..123	CDD:464199	25/114 (22%)
		COG5325	<97..276	CDD:227635	47/194 (24%)
		SNARE	188..247	CDD:473982	16/58 (28%)
Stx17	NP_663775.1	SNARE_syntaxin17	161..222	CDD:277199	18/64 (28%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250|UniProtKB:P56962	228..274		3/15 (20%)
		Required for interaction with COPB1, TMED9 and TMED10. /evidence=ECO:0000269|PubMed:21545355	273..301
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301