DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syx7 and Stx17

DIOPT Version :9

Sequence 1:	NP_730632.1	Gene:	Syx7 / 36173	FlyBaseID:	FBgn0267849	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_663775.1	Gene:	Stx17 / 252853	RGDID:	708499	Length:	301	Species:	Rattus norvegicus

Alignment Length:	272	Identity:	63/272 - (23%)
Similarity:	110/272 - (40%)	Gaps:	69/272 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QRLAQIIATS----IQKVQQNVSTMQRMVNQLNTPQDSPELKKQLHQIMTYTNQLVTDTNNQINE 84
            |:..:|:..:    ::|.|.|:...||.           .:..:||:......:.|....:.|.|
  Rat    18 QKFTKIVIPTDLERLKKHQINIEKYQRC-----------RIWDKLHEEHINAGRTVQQLRSNIRE 71

  Fly    85 VDK-CKERHLKIQRD------RLVD---EFTAALTA------FQSVQ--RKTADIEKTALRQARG 131
            ::| |    ||:.:|      |::|   |..||.||      .:||:  :|....|:..|:.:..
  Rat    72 MEKLC----LKVHKDDLILLKRMIDPMKEAAAAATAEFLQLHLESVEELKKQVKNEEALLQPSLT 132

  Fly   132 DSYNIARPPGSSRTGSSNSSASQQDNNSFFEDNFFNRKSNQQQMQTQMEEQADLQALEEQEQVIR 196
            .|..|    ....||.: .:|||                :..|:....|...|..|.|..|
  Rat   133 RSTTI----DGVHTGEA-EAASQ----------------SLTQIYALPEIPRDQNAAESWE---- 172

  Fly   197 ELENNIVGVNEIYKKLGALVYEQGLTVDSIESQVEQTSIFVSQGTENLRKASSYRNKVRKKKLIL 261
            .||.:::.::.:...:..||..|...:|||...|...::.|.:||:||:||:.|       ||..
  Rat   173 TLEADLIELSHLVTDMSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKY-------KLAA 230

  Fly   262 VGILSAVLLAII 273
            :.:..||:..::
  Rat   231 LPVAGAVIGGVV 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx7	NP_730632.1	Syntaxin_2	30..126	CDD:291208	26/117 (22%)
		COG5325	<97..276	CDD:227635	47/194 (24%)
		SNARE	188..247	CDD:304603	16/58 (28%)
Stx17	NP_663775.1	SNARE_syntaxin17	161..222	CDD:277199	18/64 (28%)
		Necessary and sufficient for localization to autophagosome. /evidence=ECO:0000250\|UniProtKB:P56962	228..274		3/15 (20%)
		Required for interaction with COPB1, TMED9 and TMED10. /evidence=ECO:0000269\|PubMed:21545355	273..301
		Endoplasmic reticulum retention signal. /evidence=ECO:0000255	298..301
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900