DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9084 and PLSCR4

DIOPT Version :9

Sequence 1:	NP_001260884.1	Gene:	CG9084 / 36172	FlyBaseID:	FBgn0033582	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001121776.1	Gene:	PLSCR4 / 57088	HGNCID:	16497	Length:	329	Species:	Homo sapiens

Alignment Length:	281	Identity:	70/281 - (24%)
Similarity:	124/281 - (44%)	Gaps:	45/281 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QQPS---LSEPRVYDSHISITSQPRPEAPRIPLP---VPIATVTGSRTLIPLS----GYDCLADL 74
            ||||   |.:| |...| .:..||    .:.|:|   |||..:.|.   .|::    |.:.|..|
Human    64 QQPSTFPLYQP-VGGIH-PVRYQP----GKYPMPNQSVPITWMPGP---TPMANCPPGLEYLVQL 119

  Fly    75 PSVHIEQTFELNDVRLPFAALTGVSSENRYVVRSPLGDAIFAANESSTEKNRLLWGAGRPFQMHL 139
            .::|:.|.||      |...:|...:.|||.:::.....::...|.:.:..|..:...|||.:.:
Human   120 DNIHVLQHFE------PLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRV 178

  Fly   140 LDKTHQEALVFRK--KLAMGSMCCQA--KSLEIWIPPGNLLGKVVQSPTFMQPEFFIEDESTGQL 200
            .|...:|.:..::  :......||.:  :.||:..|||..:|.|.:.....:..:.|::|.. :.
Human   179 TDCMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKK-EN 242

  Fly   201 TFCVEGPVGLGFCCFSLPKDCYFKIHS--GGNMRASIDHKW------LASKSQYTTNIYFSDAKL 257
            ...|.||.....|    ..|..|::.|  |.:...||..||      :|....:  :|:| ...|
Human   243 VMRVRGPCSTYGC----GSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHF--DIHF-PLDL 300

  Fly   258 TAKERALILGSAFLLEYLFFQ 278
            ..|.:|:|.|:.||:::::|:
Human   301 DVKMKAMIFGACFLIDFMYFE 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9084	NP_001260884.1	LOR	66..277	CDD:295149	52/226 (23%)
PLSCR4	NP_001121776.1	Proline-rich domain (PRD). /evidence=ECO:0000250	1..98		14/39 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		SH3-binding 1. /evidence=ECO:0000255	18..25
		PPxY motif. /evidence=ECO:0000255	30..33
		Atrophin-1	<36..100	CDD:331285	15/41 (37%)
		SH3-binding 2. /evidence=ECO:0000255	41..49
		SH3-binding 3. /evidence=ECO:0000255	98..106		1/10 (10%)
		Scramblase	100..322	CDD:252175	55/239 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920