DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9084 and Plscr1

DIOPT Version :9

Sequence 1:	NP_001260884.1	Gene:	CG9084 / 36172	FlyBaseID:	FBgn0033582	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_035766.2	Gene:	Plscr1 / 22038	MGIID:	893575	Length:	328	Species:	Mus musculus

Alignment Length:	252	Identity:	70/252 - (27%)
Similarity:	117/252 - (46%)	Gaps:	47/252 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PRIPLPVPIATVTGSRTLIPLS---GYDCLADLPSVHIEQTFELNDVRLPFAALTGVSSENRYVV 106
            |.:|.|.|           ||:   |.:.||.:..:.:.|..||.:|      |||..:.|:|.:
Mouse    93 PWMPAPPP-----------PLNCPPGLEYLAQIDQLLVHQQIELLEV------LTGFETNNKYEI 140

  Fly   107 RSPLGDAIFAANESSTEKNRLLWGAGRPFQMHLLDKTHQEALVFRKKLAMGSMC--CQAKSLEIW 169
            ::.||..::.|.|.:....|...||.|||.:.:||...:|.:...:.|...|.|  |..:.:||.
Mouse   141 KNSLGQRVYFAVEDTDCCTRNCCGASRPFTLRILDNLGREVMTLERPLRCSSCCFPCCLQEIEIQ 205

  Fly   170 IPPGNLLGKVVQSPTFMQPEFFIEDESTGQLTFCVEGPVGLGFCCFSLPKDCYFKIHSGGNMRAS 234
            .|||..:|.|.|:.....|:|.:::|.. |....|.||..:..||    .|..|::       .|
Mouse   206 APPGVPVGYVTQTWHPCLPKFTLQNEKK-QDVLKVVGPCVVCSCC----SDIDFEL-------KS 258

  Fly   235 IDHKWLASK--SQYTTNI--YFSDA---------KLTAKERALILGSAFLLEYLFFQ 278
            :|.:.:..|  .|::..:  .|:||         .|..|.:|::||:.||::::||:
Mouse   259 LDEESVVGKISKQWSGFVREAFTDADNFGIQFPLDLDVKMKAVMLGACFLIDFMFFE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9084	NP_001260884.1	LOR	66..277	CDD:295149	62/228 (27%)
Plscr1	NP_035766.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		1/2 (50%)
		Proline-rich domain (PRD). /evidence=ECO:0000250\|UniProtKB:O15162	1..93		70/252 (28%)
		SH3-binding 1. /evidence=ECO:0000255	18..26
		PPxY motif. /evidence=ECO:0000255	22..25
		SH3-binding 2. /evidence=ECO:0000255	56..64
		SH3-binding 3. /evidence=ECO:0000255	93..101		4/18 (22%)
		Scramblase	107..316	CDD:252175	64/227 (28%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O15162	269..275		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910