DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shn and Zfp423

DIOPT Version :9

Sequence 1:	NP_001260883.1	Gene:	shn / 36171	FlyBaseID:	FBgn0003396	Length:	2587	Species:	Drosophila melanogaster
Sequence 2:	XP_011246862.1	Gene:	Zfp423 / 94187	MGIID:	1891217	Length:	1312	Species:	Mus musculus

Alignment Length:	817	Identity:	160/817 - (19%)
Similarity:	250/817 - (30%)	Gaps:	261/817 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1812 GRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQ----SKTHFKKC 1872
            |..:|.|.||.....:...||.|::||:..:||.||.|...|.:..:|..|||    :|.|..|
Mouse   218 GDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAK- 281

  Fly  1873 IELGINPGPMPPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQK 1937
                         ||                        .|:..||:..:..|  ||.......:
Mouse   282 -------------SE------------------------KEAKKDDFMCDYCE--DTFSQTEELE 307

  Fly  1938 EHEAARGLLSLSMTPPIPQSVSPYPQLQDTPLPAASPANS-----IGSSGSQPKRLVCSFTSPKP 1997
            :|     :|:|.     || :|....||....|......|     |..:.:..|.     ..|..
Mouse   308 KH-----VLTLH-----PQ-LSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKH-----KCPMC 356

  Fly  1998 PFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSVPAHDLPKSQAQQMHD 2062
            |..:...|..|.:.:..:                :|..|...:||.||......:..:.......
Mouse   357 PEQFSSVEGVYCHLDSHR----------------QPDSSNHSVSPDPVLGSVASMSSATPDSSAS 405

  Fly  2063 VIFGTSGNESGFMKTLISVSDKVRISAEMEEQAKHEAEGED-------------------VQLQT 2108
            |..|::.:.:  :|.|             ..|.|...:|:.                   ..|:.
Mouse   406 VERGSTPDST--LKPL-------------RGQKKMRDDGQSWPKVVYSCPYCSKRDFTSLAVLEI 455

  Fly  2109 YIKEHALHQAKIKQSQFSRSYL--INTLYTAASPVMSSSSTLFTANSRPVMSVNEVPSIEVHEVK 2171
            ::|  .:|..|.:||...:..|  :.|||.....|..    |..:::.|||....:.:.  |...
Mouse   456 HLK--TIHADKPQQSHTCQICLDSMPTLYNLNEHVRK----LHKSHAYPVMQFGNISAF--HCNY 512

  Fly  2172 TPEAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNAN----------------LPAAVQQPDV 2220
            .||......|..|...|        .:..||...|...|                |...:||...
Mouse   513 CPEMFADINSLQEHIRV--------SHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHC 569

  Fly  2221 NEFTGVLGNPTAPPTSS-VTATSVSTTTAAPVAPS---------------STANSTQPAQRTVIV 2269
            :..:..|.:|...||.| :...|....|.:|:..|               ..|:|.:.......|
Mouse   570 SVGSTKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPV 634

  Fly  2270 GEDGFKSSTPTSK-SGDLQHVSYG-----------------------------RGVPPAPIAGDA 2304
            ..|...||....: ||....:|.|                             |
Mouse   635 SSDVEVSSPKRQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLR----------- 688

  Fly  2305 RPTCTMCSKTFQRQHQLTLHMNIHYM--ERKFKCEPCSISFRTQGHLQKHER------------- 2354
            :..|..|.:.|..|..|..|:.:|||  ...:.||.|...|.:...||||..
Mouse   689 KQACPQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLC 753

  Fly  2355 SEAHKNKVMMTSTFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLR-------SKTHVQKLECLQK 2412
            .|...:||.:.....|..::..:.:.||.|...||....|..|::       :|.| :.:.|.:
Mouse   754 QEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAH-KCIFCGE- 816

  Fly  2413 LPFGTYAEIERAGISLTEIDTSD-------CENSLISLKLLAQKLQEKD---------------P 2455
             .|.|..|::      ..|.|..       |..:..::.||.:.|:||.               |
Mouse   817 -TFSTEVELQ------CHITTHSKKYNCRFCSKAFHAVILLEKHLREKHCVFDAAAENGTANGVP 874

  Fly  2456 GKLSSYTTPSGMM-QLAQDAAGPVSQDSASEDGFSAA 2491
            ...:....|:.:. .|.::...|.|.: ||||...|:
Mouse   875 PTSTKKAEPADLQGMLLKNPEAPNSHE-ASEDDVDAS 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368
		zf-H2C2_2	499..523	CDD:290200
		C2H2 Zn finger	514..536	CDD:275368
		zf-C2H2	1816..1838	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1818..1838	CDD:275370	6/19 (32%)
		zf-H2C2_2	1830..1855	CDD:290200	11/24 (46%)
		zf-C2H2	1844..1868	CDD:278523	10/27 (37%)
		C2H2 Zn finger	1846..1868	CDD:275370	9/25 (36%)
		zf-C2H2	2307..2328	CDD:278523	6/20 (30%)
		C2H2 Zn finger	2308..2328	CDD:275368	6/19 (32%)
		zf-C2H2_jaz	2333..2359	CDD:288983	9/38 (24%)
		C2H2 Zn finger	2336..2358	CDD:275368	9/34 (26%)
		C2H2 Zn finger	2381..2403	CDD:275368	8/28 (29%)
Zfp423	XP_011246862.1	C2H2 Zn finger	168..188	CDD:275368
		C2H2 Zn finger	196..216	CDD:275368
		COG5048	222..623	CDD:227381	96/503 (19%)
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	252..272	CDD:275368	8/19 (42%)
		C2H2 Zn finger	293..312	CDD:275368	4/25 (16%)
		C2H2 Zn finger	439..460	CDD:275368	2/22 (9%)
		C2H2 Zn finger	471..495	CDD:275368	6/27 (22%)
		C2H2 Zn finger	510..529	CDD:275368	4/18 (22%)
		C2H2 Zn finger	692..712	CDD:275368	6/19 (32%)
		C2H2 Zn finger	722..743	CDD:275368	8/20 (40%)
		C2H2 Zn finger	750..771	CDD:275368	4/20 (20%)
		C2H2 Zn finger	780..801	CDD:275368	7/20 (35%)
		C2H2 Zn finger	811..831	CDD:275368	5/27 (19%)
		C2H2 Zn finger	837..855	CDD:275368	3/17 (18%)
		C2H2 Zn finger	916..937	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	989..1009	CDD:275368
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000