DRSC/TRiP Functional Genomics Resources

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Protein Alignment shn and ZNF616

DIOPT Version :9

Sequence 1:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster
Sequence 2:NP_848618.2 Gene:ZNF616 / 90317 HGNCID:28062 Length:781 Species:Homo sapiens


Alignment Length:748 Identity:143/748 - (19%)
Similarity:244/748 - (32%) Gaps:194/748 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1770 EANVAAKANEEAQAKKLETSPSGQPLVGGYESH-EDYTYIRGRGR-------------------- 1813
            |.|:..|.::.:|. .:|.:.....|...:||. .:...::..||                    
Human   116 ENNLTGKRDQHSQG-DVENNHIENQLTSNFESRLAELQKVQTEGRLYECNETEKTGNNGCLVSPH 179

  Fly  1814 ---GRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFK--KCI 1873
               ..|||:|||...|..|.|..|.|.||..:|:.|:.|..:|.....||.|....|..|  :|.
Human   180 IREKTYVCNECGKAFKASSSLINHQRIHTTEKPYKCNECGKAFHRASLLTVHKVVHTRGKSYQCD 244

  Fly  1874 ELG--------------INPGPMP----------PDSEFLDVDMDFDQQSSTSAGGRTSSMAGES 1914
            ..|              .:.|..|          ..|..|.|    .|:..|.......::.|:|
Human   245 VCGKIFRKNSYFVRHQRSHTGQKPYICNECGKSFSKSSHLAV----HQRIHTGEKPYKCNLCGKS 305

  Fly  1915 DSDDYSDNESESSDTDESKSRQKE-HEAARGLLSLSMTPPIPQSVSPYPQLQDTPLPAASPANSI 1978
            .|........::..|.|...:..| .:..:...:|::...|.....||            ..:..
Human   306 FSQRVHLRLHQTVHTGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPY------------KCDVC 358

  Fly  1979 GSSGSQPKRLVCSFTSPKPPFDYQKQEQYYSNPEESK--PKRSVANEESAPMDLTKPRGSILLIS 2041
            |.:......|||....      :..::||..| |..|  .|||                      
Human   359 GKAFRHRSNLVCHRRI------HSGEKQYKCN-ECGKVFSKRS---------------------- 394

  Fly  2042 PSPVSVPAHDLPKSQAQQMHDVIFGTSGNESG--FMK-TLISVSDKVRISAEM-------EEQAK 2096
                |:..|       :::|.|......||.|  |.| :.::|..::....:.       :..:|
Human   395 ----SLAVH-------RRIHTVEKPCKCNECGKVFSKRSSLAVHQRIHTGQKTYKCNKCGKVYSK 448

  Fly  2097 HEAEGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPV-MSSSSTLFTANSRPVMSVN 2160
            |.......::.|..|.:..::.....|..||......::|...|. .:....:|:.:||  ::|:
Human   449 HSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECGKVFSQHSR--LAVH 511

  Fly  2161 EVPSIEVHEVKTP------EAIESPRSA------------P---EQAPVILAQIAQ-------EE 2197
            .    .:|..:.|      ..:.|.|||            |   ::...:.:|.::       ..
Human   512 R----RIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGEKPYKCKECGKVFSQCSRLTVHRRIHS 572

  Fly  2198 NEEPNIAEPHNANLPAAVQQPDVNEFTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQP 2262
            .|     :|:..|....|    .::::.::|:..       ..|............:....||..
Human   573 GE-----KPYKCNECGKV----YSQYSHLVGHRR-------VHTGEKPYKCHECGKAFNQGSTLN 621

  Fly  2263 AQRTVIVGEDGFKSSTPTSKSGDLQHVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNI 2327
            ..:.:..||..:|.:...:......|:...:.|.    .||....|..|.|||:|...||.|..|
Human   622 RHQRIHTGEKPYKCNQCGNSFSQRVHLRLHQTVH----TGDRPYKCNECGKTFKRSSNLTAHQII 682

  Fly  2328 HYMERKFKCEPCSISFRTQGHLQKHER---SEAHKNKVMMTSTFG--------VPTTSNPRPFEC 2381
            |..::.:||:.|...||...||..|:|   .|.....:.....||        ....|..:|::|
Human   683 HAGKKPYKCDECGKVFRHSSHLVSHQRIHTGEKRYKCIECGKAFGRLFSLSKHQRIHSGKKPYKC 747

  Fly  2382 TDCKIAFRIHGHLAKH--------LRSKTHVQK 2406
            .:|..:|.....|.||        |.:|.:|.:
Human   748 NECGKSFICRSGLTKHRIRHTGESLTTKLNVTR 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368
zf-H2C2_2 499..523 CDD:290200
C2H2 Zn finger 514..536 CDD:275368
zf-C2H2 1816..1838 CDD:278523 11/21 (52%)
C2H2 Zn finger 1818..1838 CDD:275370 9/19 (47%)
zf-H2C2_2 1830..1855 CDD:290200 9/24 (38%)
zf-C2H2 1844..1868 CDD:278523 6/23 (26%)
C2H2 Zn finger 1846..1868 CDD:275370 6/21 (29%)
zf-C2H2 2307..2328 CDD:278523 9/20 (45%)
C2H2 Zn finger 2308..2328 CDD:275368 9/19 (47%)
zf-C2H2_jaz 2333..2359 CDD:288983 10/28 (36%)
C2H2 Zn finger 2336..2358 CDD:275368 9/24 (38%)
C2H2 Zn finger 2381..2403 CDD:275368 8/29 (28%)
ZNF616NP_848618.2 KRAB 7..61 CDD:214630
KRAB 7..46 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 105..129 3/12 (25%)
C2H2 Zn finger 187..207 CDD:275368 9/19 (47%)
zf-H2C2_2 199..224 CDD:290200 9/24 (38%)
C2H2 Zn finger 243..263 CDD:275368 2/19 (11%)
COG5048 266..707 CDD:227381 92/522 (18%)
C2H2 Zn finger 271..291 CDD:275368 4/23 (17%)
zf-H2C2_2 283..308 CDD:290200 6/28 (21%)
C2H2 Zn finger 299..319 CDD:275368 3/19 (16%)
zf-H2C2_2 311..336 CDD:290200 3/24 (13%)
C2H2 Zn finger 327..347 CDD:275368 2/19 (11%)
C2H2 Zn finger 355..375 CDD:275368 4/25 (16%)
C2H2 Zn finger 383..403 CDD:275368 8/53 (15%)
C2H2 Zn finger 411..431 CDD:275368 6/19 (32%)
C2H2 Zn finger 439..459 CDD:275368 2/19 (11%)
C2H2 Zn finger 467..487 CDD:275368 3/19 (16%)
zf-H2C2_2 480..504 CDD:290200 3/23 (13%)
C2H2 Zn finger 495..515 CDD:275368 4/25 (16%)
zf-H2C2_2 508..531 CDD:290200 3/26 (12%)
C2H2 Zn finger 523..543 CDD:275368 4/19 (21%)
zf-H2C2_2 538..560 CDD:290200 1/21 (5%)
C2H2 Zn finger 551..571 CDD:275368 1/19 (5%)
C2H2 Zn finger 579..599 CDD:275368 3/30 (10%)
zf-H2C2_2 591..616 CDD:290200 2/31 (6%)
C2H2 Zn finger 607..627 CDD:275368 2/19 (11%)
zf-H2C2_2 620..644 CDD:290200 3/23 (13%)
C2H2 Zn finger 635..655 CDD:275368 1/19 (5%)
zf-H2C2_2 647..672 CDD:290200 9/28 (32%)
C2H2 Zn finger 663..683 CDD:275368 9/19 (47%)
C2H2 Zn finger 691..711 CDD:275368 8/19 (42%)
zf-H2C2_2 703..728 CDD:290200 6/24 (25%)
C2H2 Zn finger 719..739 CDD:275368 2/19 (11%)
zf-H2C2_2 731..754 CDD:290200 4/22 (18%)
C2H2 Zn finger 747..767 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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