DRSC/TRiP Functional Genomics Resources

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Protein Alignment shn and ZFAT

DIOPT Version :9

Sequence 1:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster
Sequence 2:NP_065914.2 Gene:ZFAT / 57623 HGNCID:19899 Length:1243 Species:Homo sapiens


Alignment Length:1275 Identity:231/1275 - (18%)
Similarity:393/1275 - (30%) Gaps:448/1275 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1554 NLENVISGKQQELPLTPLHVDTPNGNAPEETSPVASASASAKSKFLRPTSLPLKPGTFTPKRHHG 1618
            |::.:|      :||.||  .||.   |..:|.........|.|..||.....|..|......:.
Human    41 NVDEII------IPLRPL--STPE---PPNSSKTGDEFLVMKRKRGRPKGSTKKSSTEEELAENI 94

  Fly  1619 ITPTANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCS-----------TKMFYCTV--NCPQ 1670
            ::||.:: || :||             .|::.....|:||           .:...|.:  |..:
Human    95 VSPTEDS-PL-APE-------------EGNSLPPSSLECSKCCRKFSNTRQLRKHICIIVLNLGE 144

  Fly  1671 PSYVAGMHKLSMYSVWQVCEEN-----QPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGK-- 1728
            ....||..  |...:.:.|:|:     ...|...|.::|..:.....|.|        :|:.|  
Human   145 EEGEAGNE--SDLELEKKCKEDDREKASKRPRSQKTEKVQKISGKEARQL--------SGAKKPI 199

  Fly  1729 LSYNLVASQQI----------VSSPSTSSTSSAF--------------------YQGPLKT---- 1759
            :|..|.|.:.|          ...|.|.:|:|..                    |:.|:|:    
Human   200 ISVVLTAHEAIPGATKIVPVEAGPPETGATNSETTSADLVPRRGYQEYAIQQTPYEQPMKSSRLG 264

  Fly  1760 PPTVTIAALSEANVAAKANEEAQAKKLETSPSGQPLVGGYESHEDYTYIRGRGRGRYVCSECGIR 1824
            |..:.|......|...|.....|| .|....:.:|                     |.|.:|...
Human   265 PTQLKIFTCEYCNKVFKFKHSLQA-HLRIHTNEKP---------------------YKCPQCSYA 307

  Fly  1825 CKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQS-----KTHFKKC---------IEL 1875
            ....:.|..|:|.||..: |.|.:|:|:..:||:|..|::.     |.|.:.|         :..
Human   308 SAIKANLNVHLRKHTGEK-FACDYCSFTCLSKGHLKVHIERVHKKIKQHCRFCKKKYSDVKNLIK 371

  Fly  1876 GINPGPMPPD---SEFLDV-------------------------DMDFDQQ-------------- 1898
            .|.....|.|   .|.||.                         ::|.|:.              
Human   372 HIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRDRHMLVHGDKWPFACEL 436

  Fly  1899 ----------------------------------------------SSTSAGGRTSSM------- 1910
                                                          ::..|...|||:       
Human   437 CGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEVHGAAQEALVFTSSINQSFCLL 501

  Fly  1911 --AGESDSDDYSD------------------NESESSDTDESKSRQKEHEAARGLLSLSMTPPIP 1955
              .|:...:...|                  .|:...||...:.| ||.||...:       |.|
Human   502 EPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDTQLEEGR-KEPEAPGEM-------PAP 558

  Fly  1956 QSVSPYPQLQDTPLPAASPANSIGSSGSQPKRLVCS--------------FTSPKPPFDYQKQEQ 2006
            ......||.:.|.||......::.||.....:.|.|              ..:|:.|.|.|.:..
Human   559 AVHLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLKNDTSSAEAHAAPEKPPDMQHRSS 623

  Fly  2007 YYSNPEE-----SKPKRSVANEES--APMDLTKPRGSILLISPSPVSVPAHDLPKSQAQQMHDVI 2064
            ..:..|.     ||.:.:.:::||  |...|.:.:...:|.:..|  .|:..| :|...:..|::
Human   624 VQTQGEVITLLLSKAQSAGSDQESHGAQSPLGEGQNMAVLSAGDP--DPSRCL-RSNPAEASDLL 685

  Fly  2065 FGTSG-----------------NESG---FMKTLISVSDKVRISAEMEEQAKHEAEGE------- 2102
            ...:|                 :.||   |||.|.|:..|...::..|...|...:.|       
Human   686 PPVAGGGDTITHQPDSCKAAPEHRSGITAFMKVLNSLQKKQMNTSLCERIRKVYGDLECEYCGKL 750

  Fly  2103 -------DVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVMSVN 2160
                   |:.::|:.:||..:.::...|..:::.|...:....|.::....|.....|.|     
Human   751 FWYQVHFDMHVRTHTREHLYYCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTP----- 810

  Fly  2161 EVPSIEVHEVKTPEAIES-PRSAPEQAPVILAQIAQEENEEPNIAEPHNANLPAAVQQPDVNEFT 2224
            :...::.| :|...|::. ..|.|         :.::...|..:.:.|.......|....::|  
Human   811 DKYKLQAH-LKVHTALDKRSYSCP---------VCEKSFSEDRLIKSHIKTNHPEVSMSTISE-- 863

  Fly  2225 GVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGFKSSTP-----TSKSG 2284
             |||                                :..|...::|:...|  .|     ..|:|
Human   864 -VLG--------------------------------RRVQLKGLIGKRAMK--CPYCDFYFMKNG 893

  Fly  2285 -DLQ-HVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPCSISFRTQG 2347
             ||| |:....||.|.        .|::|....:.:..|..|||.|..|:...|:.|...|:::|
Human   894 SDLQRHIWAHEGVKPF--------KCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKG 950

  Fly  2348 HLQKHERSEAHKNKVMMTSTFGVPTTSNP------------RPFECTDCKIAFRIHGHLAKH--- 2397
            .|:.|:.......|....:.........|            :||.|..|..:..|.|.|.:|   
Human   951 TLKSHKLLHTADGKQFKCTVCDYTAAQKPQLLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNR 1015

  Fly  2398 --------------LRSKTHVQK--LEC-LQKLPFGTYAEIER-----AGISLTEID-------- 2432
                          |.::..:|:  |:| :....:||..|..|     .|:.:.|||        
Human  1016 KHPNEEYANVGTGELAAEVLIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWETA 1080

  Fly  2433 -------------TSDCENSLISLKLLAQKLQEKDPGKLSSYTTPSGMMQLAQDAAGPVSQ--DS 2482
                         .::.|..:...:.....||:      ..||:.|| .:|...|...:.|  :.
Human  1081 TEAPEEPSTQYLHITEAEEDVQGTQAAVAALQD------LRYTSESG-DRLDPTAVNILQQIIEL 1138

  Fly  2483 ASEDGFSAAIASAIASLDNDSAGNTPKRASSMSEDETVAN 2522
            .:|...:.|:||.:|     .|..|......::|:|..:|
Human  1139 GAETHDATALASVVA-----MAPGTVTVVKQVTEEEPSSN 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368
zf-H2C2_2 499..523 CDD:290200
C2H2 Zn finger 514..536 CDD:275368
zf-C2H2 1816..1838 CDD:278523 6/21 (29%)
C2H2 Zn finger 1818..1838 CDD:275370 5/19 (26%)
zf-H2C2_2 1830..1855 CDD:290200 9/24 (38%)
zf-C2H2 1844..1868 CDD:278523 9/28 (32%)
C2H2 Zn finger 1846..1868 CDD:275370 8/26 (31%)
zf-C2H2 2307..2328 CDD:278523 6/20 (30%)
C2H2 Zn finger 2308..2328 CDD:275368 6/19 (32%)
zf-C2H2_jaz 2333..2359 CDD:288983 6/25 (24%)
C2H2 Zn finger 2336..2358 CDD:275368 6/21 (29%)
C2H2 Zn finger 2381..2403 CDD:275368 7/38 (18%)
ZFATNP_065914.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..116 19/84 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..189 8/43 (19%)
COG5048 <267..426 CDD:227381 34/181 (19%)
zf-C2H2 271..293 CDD:278523 5/22 (23%)
C2H2 Zn finger 273..293 CDD:275368 5/20 (25%)
zf-H2C2_2 285..307 CDD:290200 7/43 (16%)
C2H2 Zn finger 301..321 CDD:275368 5/19 (26%)
C2H2 Zn finger 328..349 CDD:275368 7/20 (35%)
C2H2 Zn finger 356..377 CDD:275368 2/20 (10%)
C2H2 Zn finger 406..426 CDD:275368 2/19 (11%)
C2H2 Zn finger 434..454 CDD:275368 0/19 (0%)
C2H2 Zn finger 460..478 CDD:275368 0/17 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..570 12/43 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 603..625 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 638..705 11/69 (16%)
C2H2 Zn finger 744..764 CDD:275368 1/19 (5%)
C2H2 Zn finger 772..822 CDD:275368 8/55 (15%)
C2H2 Zn finger 832..851 CDD:275368 3/27 (11%)
C2H2 Zn finger 882..903 CDD:275368 7/20 (35%)
C2H2 Zn finger 911..931 CDD:275368 6/19 (32%)
zf-H2C2_2 923..948 CDD:290200 9/24 (38%)
C2H2 Zn finger 939..959 CDD:275368 6/19 (32%)
C2H2 Zn finger 968..988 CDD:275368 1/19 (5%)
C2H2 Zn finger 996..1017 CDD:275368 6/20 (30%)
C2H2 Zn finger 1043..1061 CDD:275368 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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