DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shn and Hivep3

DIOPT Version :9

Sequence 1:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster
Sequence 2:NP_001101442.1 Gene:Hivep3 / 313557 RGDID:1311252 Length:2350 Species:Rattus norvegicus


Alignment Length:2577 Identity:570/2577 - (22%)
Similarity:878/2577 - (34%) Gaps:919/2577 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 GDAVRTTSLSSNSSLSPPPTTPLANG--HHLMTQQ-------QSHQQVQQQQQQQQTPP------ 380
            |:|:: ||:||::......||..:.|  ..|:..|       ...:..|::..|||.||      
  Rat    24 GEAIQ-TSVSSSTPYPGSSTTASSEGASQELLAPQPFSGPSVALREGAQEKTGQQQKPPRRPSIE 87

  Fly   381 -----PSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNH 440
                 |.:..|..:..|::.:      ..|.::..|.::....||...:.|              
  Rat    88 ASAHIPKLPQHPLTPAFMSPS------KPEHLLEGSTWQLVDPTRPGPSGS-------------- 132

  Fly   441 AANATLSPASFAQHQQLTQ-----PTTVSPGIPGGAAAPNPA----------------CEKSGRY 484
                .::|....|.|.|..     |....|||| ....|.|:                .:|.|:|
  Rat   133 ----FVAPGLHPQSQLLPSHASILPPEDLPGIP-KVFVPRPSQVSLKPTEEAHKKERKPQKPGKY 192

  Fly   485 VCQYCNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADA 549
            :||||:..|||||||:||||:||.||||||..||.:||||||||||.:|.:|..:| ||      
  Rat   193 ICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKA-GL------ 250

  Fly   550 DDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSP 614
               .|...:|:.....|:....|..:|||....:......:.|.|                  .|
  Rat   251 ---ASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGATS------------------GP 294

  Fly   615 AAGTLPPTTADNHHSATAQHRQSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQIQQQQQQHQLA 679
            :...||.:                     |....::||||..|                  |..:
  Rat   295 STDVLPKS---------------------KHPLLSSSLYSSGS------------------HGSS 320

  Fly   680 QQKLSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQIQ----------LQLQQQQSLLAQQSLL 734
            |::.|   .....|||..||  |..:...:|.: ||:::          |:|.:::.|:.:|:.|
  Rat   321 QERCS---QSSTAPSLEDPT--PFAEASSEHPL-SHKLEDTHTIKQKLALRLSERKKLIEEQTFL 379

  Fly   735 AAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQQQQQQQHPPLVKATPPMQQPPS 799
            :....|..    :..|:::..:|                      :||..||...|.        
  Rat   380 SPGSKGST----ESGYFSRSESA----------------------EQQVSPPNTNAK-------- 410

  Fly   800 LPPQQLV--------RANSQISSVATAPATPTPAANLSTFASSSGGKQVNVAKVQEHISKLISQN 856
             ...:::        :..|.::|.:|.|..|..|.:..:....|    |...:|.|||:|||:.|
  Rat   411 -SYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSAEDKPSLVPLS----VPRTQVIEHITKLITIN 470

  Fly   857 EAIVENKEILLQKKYPKQLSRSRSFNNANSN----NASQHG------------------------ 893
            ||:|:..||...|.....|:|..|..:..|:    :.|.||                        
  Rat   471 EAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRESLSSHGEKTKQEQSLLSLQHPPSSTHPVPL 535

  Fly   894 ----SNASALHANNSQNNT------------NAQMPERETKVNLAQAIFQKQQHQLQ-------- 934
                |..||....::.::|            :.::|.|.|.|..:.....|:|..::        
  Rat   536 LRSHSMPSAACTISTHHHTFRGSYSFDDHIADPEVPSRSTPVFTSHPRMLKRQPAIELPLGAEYS 600

  Fly   935 -------------------QQQQQQITQQQQQQLEQQ--NYYTYI-------------QQQQECQ 965
                               :.::..:|::.::.|:.:  ||...|             .::..|.
  Rat   601 SEEPGPSSKDPITKPSDEPEPKESDLTKKTKKGLKTKGVNYECTICGARYKKRDNYEAHKKYYCS 665

  Fly   966 QQQLEP--PNG---VVKRNA----------YKPGVVM-TTPVKQQ--------QQLPP---PPSP 1003
            :.|:..  |.|   |.|..|          ||.|..: .||::::        ::.||   .|.|
  Rat   666 ELQITKAHPAGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPGFSSPGP 730

  Fly  1004 ------LPMQTMQYRQDPATPVTKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTSSLAPTPT 1062
                  ||:::.:...:.:..|..:|.||:..|       ..|||...:.|.....|.|   ...
  Rat   731 SDAAHNLPLESTKSPAEASKSVPTLEGPTSFQP-------RTPKPGSGSEPGKERRTMS---KEI 785

  Fly  1063 TSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAVPIGEGDD--AVYSCPICASEFRSADDL--K 1123
            :....|||.:.:.||.|..:.                 |.|.  |.:|.|..|...|||..|  :
  Rat   786 SVIQHTSSFEKSDPPEQPGSL-----------------EEDKPLAPFSSPPPAPHGRSAHSLQPR 833

  Fly  1124 LHNSTYCQ----------DASSSAPMSPASSPFRSNSI-----SLSLPELKSH-MANSKNPLSLA 1172
            |......|          |...:.|..|...|.::...     |.:|.:|.:. :...|..|.||
  Rat   834 LVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLA 898

  Fly  1173 KLAWSQLKTK-RSSLVLSR---------LSA--------------AQTPARTSTVTAPTV----- 1208
            ::|.|..::. .||:.|||         ||.              |:||...|...:.|:     
  Rat   899 EMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAETPGPLSDTRSKTLGTHML 963

  Fly  1209 --------------TASAPAPAV------------------ATVTAPSSA-PAPQIEALRFVDAP 1240
                          :||..:|.|                  .:.|.||.| ||.         .|
  Rat   964 TVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSVAVPAA---------PP 1019

  Fly  1241 LPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPT 1305
            .|:..|...|..||..|..|.|.:|:               :||.|..:        ..||::|:
  Rat  1020 PPAAPPERRKCFLVRQASLSRPPEAE---------------LEATPKGK--------QESSEEPS 1061

  Fly  1306 SFNFSFNNQNSSNSVPELQSSKEERLRRFTSSGGSMIPISECPDLDNSPKMIRT----------- 1359
            :...|..:..:..||..:|.          ...||...:.:.|.|.:||.....           
  Rat  1062 ASKPSTKSSMAQISVATIQG----------GLSGSKSQMQDRPPLGSSPPYTEALQVFQPLGTQL 1116

  Fly  1360 -PLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGLLGVSSG-----PQHFQFPPIN-SITAF 1417
             |.:|..|.|.:   :..|...||:.....|:   :|||.....     |..||.||:. ..|..
  Rat  1117 PPPVSLFSLQQL---LPQEQEQSSEFFPTQAM---AGLLSSPYSVPPLPPSLFQAPPLPLQPTVL 1175

  Fly  1418 NP--LTLPPMSGGDKTTP------VTPIP----------------------------HVP----- 1441
            :|  |.||.:.......|      ..|:|                            |:|     
  Rat  1176 HPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPSIKTS 1240

  Fly  1442 ------GMPGPGS------------LTPQ-------------MPLLPPP------PQQLQLPIPS 1469
                  |.|||.|            :|||             :|..|..      |.::|..:||
  Rat  1241 LPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSASPLALPACPDAMVSLVVPVRIQTHMPS 1305

  Fly  1470 ----------------------------------------------------------SRG---- 1472
                                                                      |||    
  Rat  1306 YGSAMYTTLSQILVTQSPGSSTSMALTKYEEPSSKSMTVCGADVYEAEPGPSSISKEQSRGFQTP 1370

  Fly  1473 --RSPNRK-----QPSPLLLGG----GSGELKALSPFGGVQNVPSEFSRQPPTPAQRQALQWNSK 1526
              |.|.||     ....|.|.|    .||..:.|||.|.:     |.:.:  |..|::..:..:.
  Rat  1371 YLRVPERKGTALSSEGILSLEGCSSTASGSKRVLSPAGSL-----ELTME--TQQQKRVKEEEAS 1428

  Fly  1527 EAPKK----APFNFLRMA--DNVKTTEPEV--------RHFNLENVISGKQQELPLTPLHVDT-P 1576
            :|.:|    :..|.:..:  |..||.:|.|        ....|..:.|.......|:||...| .
  Rat  1429 KADEKLELVSTCNVVLTSTEDRKKTEKPHVGSQGRSRRETETLSCLSSDVSDPKELSPLSQSTLS 1493

  Fly  1577 NGNAP--EETSPVASASASAKSKFLRPTSLPLKPGTFTPKRHHGITPTA--NTLPLISPETPRP- 1636
            :|.||  |.....|..|:.|..:.|.|.|:..:    .||....:.|.|  ::||| |..:||| 
  Rat  1494 HGTAPGSEALKEYAQPSSKAHRRCLPPLSVKKE----DPKEQTDLPPLAPPSSLPL-SDTSPRPA 1553

  Fly  1637 -------SKSCVQLYLNGHAYTYLGLKCSTKMFYCTVNCPQPSYVAGMH---KLSMYSVWQVCEE 1691
                   ||..:|         :..|..:|.:.:|.:|..:|:::  .|   :.|:|:.|.:...
  Rat  1554 KLQEGTDSKKVLQ---------FPSLHTTTNVSWCYLNYIKPNHI--QHADRRSSVYAGWCISLY 1607

  Fly  1692 NQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQIVSSPSTSSTSSAFYQGP 1756
            | |:..|...|..::|..|:|::            .|.:|.:..:....:.....|.|.......
  Rat  1608 N-PNLPGVSTKAALSLLRSKQKV------------SKETYTMATAPHPEAGRLVPSNSRKPRMTE 1659

  Fly  1757 LKTPPTVTIAALSEANVAAKANEEAQAKKLETSPSGQP-----LVGGYESHEDYTYIRGRGRGRY 1816
            :..|..|::.  |:.:.|....||...:...||..|:|     ..|||:|:|:|.|:||||||:|
  Rat  1660 VHLPSMVSLE--SQKDPARVEKEEKAEEGTPTSKRGEPTRVKIFEGGYKSNEEYIYVRGRGRGKY 1722

  Fly  1817 VCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGP 1881
            ||.||||||||||||||||||||||||:.|.||:|:|||||||||||:||.|.|||.|.|:    
  Rat  1723 VCEECGIRCKKPSMLKKHIRTHTDVRPYVCRHCHFAFKTKGNLTKHMKSKAHSKKCQETGV---- 1783

  Fly  1882 MPPDSEFLDVDMDFDQQSSTSAGGRTSSMA-----------GESDSDDYSDNESESSDTDESKSR 1935
                .|.|:.:..........:.||..|.|           .:||||...|.|.|..:.:||:..
  Rat  1784 ----LEELEAEEGTSDDLLQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEEESQDE 1844

  Fly  1936 QKEHEAARGLLSLSMTPPIPQSVSPYPQLQDTPLPAASPANSIGSSGSQPKRLVCS--------- 1991
            .....:....|.|..|.....|:...||    |..|.|.|...|||.|:..||..|         
  Rat  1845 LSRPSSEAAPLCLPATLQEDSSLIRGPQ----PPDATSDAAPRGSSISEATRLTASSCSTPSQGT 1905

  Fly  1992 ----------------------FTSPKPPFDYQKQ-------------EQYYSNPEESKPKRSVA 2021
                                  .|||:.|:...|:             .:..|:|:...|.|:.|
  Rat  1906 QGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKTDSSPQRCSPARAQA 1970

  Fly  2022 NEESAP-------MDLT-----KPRGSILLISPSPV--SVPA------------------HDLPK 2054
            :..|.|       .||:     .||..:..::|.|:  .|||                  ..|.:
  Rat  1971 SVASTPGPQTGPGRDLSPHLCGSPRPELSCLTPYPIGREVPAGLESATVTGTPRCSPTRRRSLGR 2035

  Fly  2055 SQAQQMHDVIFGT---------SGNESG---------------FMKTLISVSDKVRISAEMEEQA 2095
            :::...|.|:.||         |.::.|               ...||:|.|.:...||...|..
  Rat  2036 AESSPPHTVLPGTWALGGPCSPSVDKYGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWKTESR 2100

  Fly  2096 KHEAEGEDVQLQTYIKEHALH---QAKIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVM 2157
            ...|....:..:.....|..|   .::.:::.||...| ::.:...:|.             |::
  Rat  2101 SPSAGPAPLSSRPSSAPHDFHGHLPSRSEENLFSHLPL-HSQHLNRTPC-------------PLI 2151

  Fly  2158 SVNEVPSIEVHEVKTP-------------------------EAIESPRSAPEQAP---------V 2188
            .:..:..::......|                         ||.|..|.:|.::|         |
  Rat  2152 PIGGIQMVQARPGAHPTLLSGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKV 2216

  Fly  2189 ILAQIAQEENEE--------PNIAEPHNANLPAAVQ-------------QPDVNEFTGVLGNPTA 2232
            ....::.|..||        |...|||.|..||...             .|....:.|:|.:|.|
  Rat  2217 SKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMGTHSPCPPQLPQGHPLAPSWRGLLESPHA 2281

  Fly  2233 ---------PPTSSVTATSVSTTTAAPVAPSSTANSTQPAQR 2265
                     ||....::......|:....|.|...|.:|..|
  Rat  2282 LANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNLSGEPRTR 2323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 15/19 (79%)
zf-H2C2_2 499..523 CDD:290200 16/23 (70%)
C2H2 Zn finger 514..536 CDD:275368 14/21 (67%)
zf-C2H2 1816..1838 CDD:278523 20/21 (95%)
C2H2 Zn finger 1818..1838 CDD:275370 18/19 (95%)
zf-H2C2_2 1830..1855 CDD:290200 19/24 (79%)
zf-C2H2 1844..1868 CDD:278523 17/23 (74%)
C2H2 Zn finger 1846..1868 CDD:275370 17/21 (81%)
zf-C2H2 2307..2328 CDD:278523
C2H2 Zn finger 2308..2328 CDD:275368
zf-C2H2_jaz 2333..2359 CDD:288983
C2H2 Zn finger 2336..2358 CDD:275368
C2H2 Zn finger 2381..2403 CDD:275368
Hivep3NP_001101442.1 C2H2 Zn finger 194..214 CDD:275368 15/19 (79%)
zf-H2C2_2 207..231 CDD:290200 16/23 (70%)
C2H2 Zn finger 222..242 CDD:275368 13/19 (68%)
zf-C2H2 1722..1744 CDD:278523 20/21 (95%)
C2H2 Zn finger 1724..1744 CDD:275368 18/19 (95%)
zf-H2C2_2 1736..1761 CDD:290200 19/24 (79%)
C2H2 Zn finger 1752..1774 CDD:275368 17/21 (81%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 107 1.000 Domainoid score I6377
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 319 1.000 Inparanoid score I2452
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45702
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45944
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
77.110

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