DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shn and HIVEP1

DIOPT Version :9

Sequence 1:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster
Sequence 2:XP_011512848.1 Gene:HIVEP1 / 3096 HGNCID:4920 Length:2727 Species:Homo sapiens


Alignment Length:2949 Identity:639/2949 - (21%)
Similarity:985/2949 - (33%) Gaps:978/2949 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   193 VDSNHI-------ISNNNNNNNNNNTSNNN-------NNNHHSDNSIS-ENNYEF---------- 232
            |..||:       :.|.....:..||..::       :.:|...|.|. :|..:|          
Human    63 VAENHLKKIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPVKNGKQFTKQNGETPGI 127

  Fly   233 ---KSRDKASLSDSK-MTLQQMAAV----SSNQEPVAPNVANTMSNSSIINSQQTTVNATPATDE 289
               .|:.:.|:|..| :.|||.:.:    |...:|...:..:...:||.::|:..|.|:...:..
Human   128 IAEASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLDEQCDSSSLSSKTRTDNSECISSH 192

  Fly   290 APLGDRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPP----- 349
            ......|    |.:..|..|....|.:..:.:..|     |..|::|..|..|.:...||     
Human   193 CGTTSPS----YTNTAFDVLLKAMEPELSTLSQKG-----SPCAIKTEKLRPNKTARSPPKLKNS 248

  Fly   350 --TTPLANGHHLMTQQQS-------HQQVQQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEE 405
              ..|......|:.:.||       |....|:.:|......|...|:.......||.     |.:
Human   249 SMDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGAMQSASHLYHQHEHFVPKSNQ-----HNQ 308

  Fly   406 SIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATL---SPASFA----QHQQL--TQPT 461
            .:...||:..:      |.|..:..|:......|.|..:::   ||:|.:    |:||:  ..|.
Human   309 QLPGCSGFTGS------LTNLQNQENAKLEQVYNIAVTSSVGLTSPSSRSQVTPQNQQMDSASPL 367

  Fly   462 TVSPG-------IP-----GGAAAPNPACE-------------KSGRYVCQYCNLICAKPSVLEK 501
            ::||.       :|     ..|:..|.:.|             |.|:|:|:|||..|||||||.|
Human   368 SISPANSTQSPPMPIYNSTHVASVVNQSVEQMCNLLLKDQKPKKQGKYICEYCNRACAKPSVLLK 432

  Fly   502 HIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGLEVPADA----------------- 549
            |||:||.||||||.|||.:||||||||||.:|.:|..:. ||.:..||                 
Human   433 HIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKL-GLVLQPDAGGLFLSHESPKALSIHS 496

  Fly   550 ---DDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPT----YMQ 607
               |.|.|:::........:|    |:...:|::......:..:..||::....|...    .:|
Human   497 DVEDSGESEEEGATDERQHDL----GAMELQPVHIIKRMSNAETLLKSSFTPSSPENVIGDFLLQ 557

  Fly   608 QLPLGSPAAGTLPPTTADNHHSATAQHR----QSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQ 668
            .....|.|...||....  ||...:..|    :::|.||                ||...|:|..
Human   558 DRSAESQAVTELPKVVV--HHVTVSPLRTDSPKAMDPKP----------------ELSSAQKQKD 604

  Fly   669 IQQQQQQHQLAQQKLSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQ----------------- 716
            :|....|            ||       ...:|.....:::.:.||||                 
Human   605 LQVTNVQ------------PL-------SANMSQGGVSRLETNENSHQKGDMNPLEGKQDSHVGT 650

  Fly   717 IQLQLQQQQ----SLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQ 777
            :..|||:||    |...|..||:....|..    ...|:::..:|                    
Human   651 VHAQLQRQQATDYSQEQQGKLLSPRSLGST----DSGYFSRSESA-------------------- 691

  Fly   778 QQQQQQHPPLVKATPPMQQPPSLPPQQLVRANSQISSVATAPATPT--PAANLSTFASSSGGKQV 840
              .|...||    ||..::.|| ..|...|:|...:::.|. :||:  |....:..........:
Human   692 --DQTVSPP----TPFARRLPS-TEQDSGRSNGPSAALVTT-STPSALPTGEKALLLPGQMRPPL 748

  Fly   841 NVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANS------------------- 886
            ....::|.||||||.|||:|::|::...|.....|||..|.::..|                   
Human   749 ATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPVGRRTS 813

  Fly   887 ---------------------------------NNASQHGSNASALHAN---------NSQ---- 905
                                             .:.|...:..||:.||         .||    
Human   814 SSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPANIIPPPHPLRGSQSFDD 878

  Fly   906 -----------NNTNAQMPE-------------RETKVN-------------------------- 920
                       :..||.:|:             .::..|                          
Human   879 KIGAFYDDVFVSGPNAPVPQSGHPRTLVRQAAIEDSSANESHVLGTGQSLDESHQGCHAAGEAMS 943

  Fly   921 -----LAQA--IFQKQQHQLQQQQ-QQQITQQQQQQLE----QQNYYTYIQQQQECQQQQLEP-- 971
                 |||.  |.:|:.||.:... :.:..:.:.::||    .:.:|.......:.:....||  
Human   944 VRSKALAQGPHIEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAMREPEH 1008

  Fly   972 ---PNGVVK-----RNAYKPGVVMTTPV-------------KQQQQLPPPPSPLPMQTMQYRQ-- 1013
               |.|:..     |.|...|:...||.             ::.||.....||...:.:|::.  
Human  1009 SPVPGGLQPQILHYRVAGSSGIWEQTPQIRKRRKMKSVGDDEELQQNESGTSPKSSEGLQFQNAL 1073

  Fly  1014 --DPATP---VT--------KIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLS------------ 1053
              :|:.|   ||        .|:...:.:.::.........|.|.|:....:|            
Human  1074 GCNPSLPKHNVTIRSDQQHKNIQLQNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRH 1138

  Fly  1054 ---------TSSLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAV----PIGEG--- 1102
                     |:||: .|.:...|....:.:|...|..|...|:..|...|::.    |..:|   
Human  1139 GTGISVIQHTNSLS-RPNSFDKPEPFERASPVSFQELNRTGKSGSLKVIGISQEESHPSRDGSHP 1202

  Fly  1103 -----DDAVYSCPICASEFRSADD----------LKLHN----------------STYCQDASSS 1136
                 .||:.. .:..|..:|..:          ::.||                ...|.|...|
Human  1203 HQLALSDALRG-ELQESSRKSPSERHVLGQPSRLVRQHNIQVPEILVTEEPDRDLEAQCHDQEKS 1266

  Fly  1137 APMSPASSPFRSNSISLSLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTS 1201
            ...   |.|.||.::| .||..|  :...|..|.||::..|..::...|.:...||...:.:.||
Human  1267 EKF---SWPQRSETLS-KLPTEK--LPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTS 1325

  Fly  1202 TVTAP------TVTASAP------------APA-VATVTAP------------------SSAPAP 1229
            :.:|.      :.|.::|            .|| :.|:..|                  :|....
Human  1326 SFSASLDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSMEVS 1390

  Fly  1230 QIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSD 1294
            .:.:..|....:..|    ..|||.:....|:|.:    |.:|. |..   ::|.:....::...
Human  1391 DLRSKSFDCGSITPP----QTTPLTELQPPSSPSR----VGVTG-HVP---LLERRRGPLVRQIS 1443

  Fly  1295 LVVASSSQ----QPTSF------------------------NFSFNNQNSSNSVPELQSSKEERL 1331
            |.:|..|.    .||||                        .||.|..:|...|.:||:...   
Human  1444 LNIAPDSHLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAETS--- 1505

  Fly  1332 RRFTSSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGL 1396
               .||..::.|:.:..|: |....|..|    .|.|...:.:...|..|..::.  :::|||..
Human  1506 ---NSSSTNVFPVQQLCDI-NLLNQIHAP----PSHQSTQLSLQVSTQGSKPDKN--SVLSGSSK 1560

  Fly  1397 LGVSSGPQ---HFQFPPINSITAFNPL-TLPPMSGGDKTTPVTPIPHVPGMPGPGSLTPQM---- 1453
            ......|:   |.|........:.||: :||.....|   ||.....|.....|..|...|    
Human  1561 SEDCFAPKYQLHCQVFTSGPSCSSNPVHSLPNQVISD---PVGTDHCVTSATLPTKLIDSMSNSH 1622

  Fly  1454 PLLPPP-----------PQQLQLPIPSSRGRS----------------------PNR-------- 1477
            |||||.           |....|||   |.:|                      ||:        
Human  1623 PLLPPELRPLGSQVQKVPSSFMLPI---RLQSSVPAYCFATLTSLPQILVTQDLPNQPICQTNHS 1684

  Fly  1478 ------KQPS-PLLLGGGSGELKALSPFGGVQNVPSEFSRQ-------PPT---PAQRQALQWNS 1525
                  :|.| |.|..|....|.........:||.||.|:.       |.|   ...|.:.|..|
Human  1685 VVPISEEQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPITQKISVGRLSPQQES 1749

  Fly  1526 KEAPKK--APFNFLRMA----------DNVKTTEPEVRHFNL--ENVISGKQQELPLTPLHVDTP 1576
            ..:.|:  :|.|.|.:|          :|......:||....  ..|....:|:.|:....|.|.
Human  1750 SASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALSSRVNEASKQKKPILVRQVCTT 1814

  Fly  1577 NG-----------NAPEETSPV--------ASASASAKSKF--LRP-------------TSLPL- 1606
            ..           :.||.::..        |..|::..|||  :.|             |||.| 
Human  1815 EPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTGCSKFVVIEPISELQEFENIKSSTSLTLT 1879

  Fly  1607 ---KPGTFTPKRHHGITP---TANTLPLISP---------------ETPRPSKSCVQLYLNGHAY 1650
               .|   .|..:..|:|   |.|.....||               :.|..|.|...: .:....
Human  1880 VRSSP---APSENTHISPLKCTDNNQERKSPGVKNQGDKVNIQEQSQQPVTSLSLFNI-KDTQQL 1940

  Fly  1651 TYLGLKCSTKMFYC------TVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYD 1709
            .:..||.:|...:|      :::.||..     .|.|.|:.|.|...| |:|||...|..:||.:
Human  1941 AFPSLKTTTNFTWCYLLRQKSLHLPQKD-----QKTSAYTDWTVSASN-PNPLGLPTKVALALLN 1999

  Fly  1710 SRQRMLGNGSSTAMAGSGKLSY-----NLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTIAALS 1769
            |:|            .:||..|     ....|..:|.|....|:.|....|..|:    |:...|
Human  2000 SKQ------------NTGKSLYCQAITTHSKSDLLVYSSKWKSSLSKRALGNQKS----TVVEFS 2048

  Fly  1770 EANVAAKANEEAQAKK--LETSPSGQPLV-GGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSML 1831
            ..: |::.|.|...:.  :::.|....:. |||:|:|:|.|:||||||:|:|.||||||||||||
Human  2049 NKD-ASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSML 2112

  Fly  1832 KKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPM-PPDSEFLDVDMDF 1895
            ||||||||||||:.|::|||||||||||||||:||.|.|||::||::.|.: ..|:|..|....|
Human  2113 KKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRF 2177

  Fly  1896 DQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARGLLSLSMTPPI---PQS 1957
            ..:       |:.....|||..|..|||:|..|.|.    |.|.       .||.||.:   ||.
Human  2178 SYE-------RSGYDLEESDGPDEDDNENEDDDEDS----QAES-------VLSATPSVTASPQH 2224

  Fly  1958 VSPYPQLQD------------------------------TPLPAASPANS-----IGSSGSQPKR 1987
            :.....|||                              |.:...|.|.|     ..|.|...:|
Human  2225 LPSRSSLQDPVSTDEDVRITDCFSGVHTDPMDVLPRALLTRMTVLSTAQSDYNRKTLSPGKARQR 2289

  Fly  1988 LVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSV---PA 2049
            .........|..|..:...:         :.||...||..:..:...|..:.|:.||.||   ||
Human  2290 AARDENDTIPSVDTSRSPCH---------QMSVDYPESEEILRSSMAGKAVAITQSPSSVRLPPA 2345

  Fly  2050 ------------------HDLPKSQAQQM-----------HDVIFG----TSGNESGFMKTLISV 2081
                              |..|:.|.||:           |..:|.    .|..:|.....::.|
Human  2346 AAEHSPQTAAGMPSVASPHPDPQEQKQQITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVPV 2410

  Fly  2082 SDKVRISAEMEEQAKHEAEGEDVQLQTYIKEHALHQAKIKQSQFSRSYLINTLYTAASPVMSSSS 2146
            .....:.|.:                ||.....|....::.:..:.|.:..||.|..:.|...|.
Human  2411 GGIHVVPAGL----------------TYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSG 2459

  Fly  2147 TLFTANSRPVMSVNEVPSIEVHEVKTP--EAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNA 2209
            |...|....:.||  ||.|.:.:::.|  :.:.:|.         |..:.....|..||....|.
Human  2460 TTNPAGVAELSSV--VPCIPIGQIRVPGLQNLSTPG---------LQSLPSLSMETVNIVGLANT 2513

  Fly  2210 NLPAAVQQPDVNEFTGVLGNPTAPPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGF 2274
            |:     .|.|:           ||..::.|..:...||.|.:.||      ||.:..|.|....
Human  2514 NM-----APQVH-----------PPGLALNAVGLQVLTANPSSQSS------PAPQAHIPGLQIL 2556

  Fly  2275 KSSTPTSKSGDLQHVSYGRGVPPAPIAGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPC 2339
            ..:.||......|.....:|.|..|.:.         ||.                     ||  
Human  2557 NIALPTLIPSVSQVAVDAQGAPEMPASQ---------SKA---------------------CE-- 2589

  Fly  2340 SISFRTQGHLQKHERSEAHKNKVMMT-STFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLRSKTH 2403
                     .|..:.|.|..|:|..| |..|:||                               
Human  2590 ---------TQPKQTSVASANQVSRTESPQGLPT------------------------------- 2614

  Fly  2404 VQKLECLQKL----PFGTYAEIERAGISLTEIDTSDCENS--------LISLKLLAQKLQEKDP- 2455
            ||:....:.|    |.|.:|.::    .|:::||....::        |.|::  .|......| 
Human  2615 VQRENAKKVLNPPAPAGDHARLD----GLSKMDTEKAASANHVKPKPELTSIQ--GQPASTSQPL 2673

  Fly  2456 --GKLSSYTTPSGMMQLAQDAAGP 2477
              .....:|.|||...|:.|...|
Human  2674 LKAHSEVFTKPSGQQTLSPDRQVP 2697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 15/19 (79%)
zf-H2C2_2 499..523 CDD:290200 17/23 (74%)
C2H2 Zn finger 514..536 CDD:275368 15/21 (71%)
zf-C2H2 1816..1838 CDD:278523 19/21 (90%)
C2H2 Zn finger 1818..1838 CDD:275370 18/19 (95%)
zf-H2C2_2 1830..1855 CDD:290200 20/24 (83%)
zf-C2H2 1844..1868 CDD:278523 18/23 (78%)
C2H2 Zn finger 1846..1868 CDD:275370 18/21 (86%)
zf-C2H2 2307..2328 CDD:278523 2/20 (10%)
C2H2 Zn finger 2308..2328 CDD:275368 2/19 (11%)
zf-C2H2_jaz 2333..2359 CDD:288983 5/25 (20%)
C2H2 Zn finger 2336..2358 CDD:275368 4/21 (19%)
C2H2 Zn finger 2381..2403 CDD:275368 0/21 (0%)
HIVEP1XP_011512848.1 C2H2 Zn finger 417..437 CDD:275368 15/19 (79%)
zf-H2C2_2 430..454 CDD:290200 17/23 (74%)
C2H2 Zn finger 445..465 CDD:275368 14/19 (74%)
zf-C2H2 2097..2119 CDD:278523 19/21 (90%)
C2H2 Zn finger 2099..2119 CDD:275370 18/19 (95%)
zf-H2C2_2 2111..2136 CDD:290200 20/24 (83%)
zf-C2H2_2 <2125..2190 CDD:289522 31/71 (44%)
C2H2 Zn finger 2127..2145 CDD:275370 15/17 (88%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4892
eggNOG 1 0.900 - - E33208_3BEXG
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 352 1.000 Inparanoid score I2266
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41578
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45944
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3898
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
88.040

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