Protein Alignment shn and hivep3a

DIOPT Version :10

• Sequence 1: NP_001260883.1
• Gene: shn / 36171
• FlyBaseID: FBgn0003396
• Length: 2587
• Species: Drosophila melanogaster
• Sequence 2: XP_005159605.1
• Gene: hivep3a / 101883448
• ZFINID: ZDB-GENE-081029-2
• Length: 1797
• Species: Danio rerio
• Alignment Length: 2215
• Identity: 462/2215 - (20%)
• Similarity: 753/2215 - (33%)
• Gaps: 779/2215 - (35%)

  Fly   335 RTTSLSSNSSLSPPPTTPLANG--------------HHLMTQQQSHQQVQQQQQQQQTPPPSVAI 385
            :.|:...:..|:....||:.|.              ||  .||:.|..:::::.:.|.
Zfish     7 QATTGEQSGGLAKQNETPVDNPKPQYHEEKKVVTQVHH--AQQRKHLNIERKRLRLQR------- 62

  Fly   386 HEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATLSPAS 450
                         .::...:.:......:|:|.:.    :.|:|.:......|..:::|..:..|
Zfish    63 -------------KSLQERDVVEEGKPPRASGSSE----HLNANMSQAREMPSGASSSAVSAKPS 110

  Fly   451 FAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHIRAHTNERPYPCD 515
            .:..:       |..|.|.......|  :|.|:|||.||...|||||||:||||:||.||||||.
Zfish   111 CSMEE-------VLEGTPRQKRERKP--QKPGKYVCSYCGRACAKPSVLQKHIRSHTGERPYPCA 166

  Fly   516 TCGIAFKTKSNLYKHCRSRSHAARARGLEVPADAD-DGLSDQDAELSNSSSELPSRAGSPYEEPI 579
            .||.:||||||||||.:|.:|..:| ||  .||.: .|:|..:..|::|..|         .:|
Zfish   167 PCGFSFKTKSNLYKHRKSHTHRVKA-GL--TADREGPGISCSEEPLTDSDEE---------SQP- 218

  Fly   580 NSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSPAAGTLPPTTADNHHSATAQHRQSIDYKPYK 644
                          |:|::                                  :.|.|:.
Zfish   219 --------------SSYLE----------------------------------KQRMSVQ----- 230

  Fly   645 PKFHNASLYSCSSKELQQQQQQLQIQQQQQQHQLAQQKLSIQLPLVQQPSL-AHPTLSPSTQMKM 708
               ::::...||         :.|:|:.:..|.: :::|:::|...::..| :....|.|.....
Zfish   231 ---NSSATERCS---------EGQLQEIEDSHAV-KKRLAMRLSRGRRTPLGSSDEASSSFGQSS 282

  Fly   709 KHHINSHQIQLQLQQQQSLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHL 773
            |....|....   :.:.:.::|.|     ||              :|:|..:...:..:..::..
Zfish   283 KGSTESGYFS---RSESTEVSQDS-----PP--------------NTSAKSYAEVILGKFGRLGH 325

  Fly   774 AQQQQQQQQQHPPLVKATPPMQQPPSLPPQQLVRANSQISSVATAPATPTPAANLSTFASSSGGK 838
            .|:...||..||                                               :...||
Zfish   326 LQRTSHQQHAHP-----------------------------------------------AGQEGK 343

  Fly   839 QV--NVAKVQ--EHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFN----------------- 882
            ::  ||.|.|  :||:|||:.|||:|:..:|...|  |::.|.||..:
Zfish   344 RIPFNVPKKQVIDHITKLITINEAVVDTSKIDSVK--PRRFSLSRRSSTELKVVSSKEPFLHSPK 406

  Fly   883 ----NANSNNA-------------------SQHGSNASALHANNSQNN-TNAQMPERETKVNLAQ 923
                :|.|:.:                   ::..|.|..|.:::..:: :.:.:.|....:.|:|
Zfish   407 EIDISAKSSGSITLGVPCEKFQHHSLSIPQTESTSTAPLLRSHSMPSDASTSDVSETSRSLRLSQ 471

  Fly   924 AI-----FQKQQH-QLQQQQQQQITQQQQQQLEQQNYYT--------------YIQQQQECQQQQ 968
            :.     .|.::| .|::|...::....:..:|:|:|.|              ..|:|.||...:
Zfish   472 SFDDPQPIQNRRHGMLRRQPAIELPIGAELTMEEQSYSTSSFHHPVTTMPDPSQKQEQFECGACR 536

  Fly   969 LEPPNGVVKRNAYKPGVVMTTPVKQQQQLPPPPSPLPMQTMQYRQDPATPVTKIEQPTTAVPVMP 1033
            : ..|.|.:...:|.. ..|..:.||.::|           .|:.|.:|..........|
Zfish   537 I-VCNDVERYQKHKQH-CCTVHISQQSEIP-----------VYQVDESTRTFTSRSGAFA----- 583

  Fly  1034 LNLSAKPKPTLVTVPVSSLSTSSLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAVP 1098
              ...:.|...:.....||.:.|..|                                .||.|
Zfish   584 --FRKRRKEESIEFEDPSLPSVSYIP--------------------------------LRGYA-- 612

  Fly  1099 IGEGDDAVYSCPICASEFRSADDLKLHNSTYCQDAS-SSAPMSPASSPFRSNSISLSLPELKSHM 1162
                       |.|....:...:|   ...||.:.| ....:...:|.|..:..|.:.....:|.
Zfish   613 -----------PSCEQPIKRTHEL---GQEYCTEGSLKGISVIQHTSSFEKHDNSKTDEPSHTHG 663

  Fly  1163 ANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTSTVTAPT-VTASAPAPAVATVTAPSSA 1226
            .:..:|....|    |..||.|...|.|....|.|....|..:.| ..|.:|.|.|     |...
Zfish   664 VSHTSPHPQTK----QQATKLSFRKLVRQQNVQVPEILVTEDSNTEAMAVSPPPIV-----PKMK 719

  Fly  1227 PAPQIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIK 1291
            ...::...::     |...|.|.:.|:    ::..|:|                       ||::
Zfish   720 DTEKVSEFQW-----PQRSPTLAQLPI----EKLPPKK-----------------------KRLR 752

  Fly  1292 TSDLVVASSSQQPTSFNF----------SFNNQNSSNSVPELQSSKEER----LRRFTSSGGSMI 1342
               |..|:.|...:||..          |..:.|||.|....::.|.:.    .||..::....:
Zfish   753 ---LAEAAQSSGDSSFESMSLPHSPSQDSCTSHNSSRSTSFEEAGKADADLTPTRRSRATHTLTV 814

  Fly  1343 PIS-----------ECPDLDNSPKMIRTPLLSGGSFQDVSVKVNNETGSSSKERKLMALV----- 1391
            ||:           :.|.:..:..:|..  :...|| |.|....:.|.:..|||:...|:
Zfish   815 PINSHREMRRSASEQAPHIPQTANLITE--IRSKSF-DYSSLSPDRTPAGWKERRKCLLLRHSAV 876

  Fly  1392 --------------SGSGLLGVSSGPQHFQFPPINSITAFNPLTLPPMSG------GDK------ 1430
                          :.|.....|:.|.|      :.:|:::|.|....|.      |:|
Zfish   877 REPEEEDQTTKVFNTSSPTCRTSTSPSH------SPVTSYSPSTHHVSSSNTVHSFGEKQIMKSQ 935

  Fly  1431 ----------TTPVTPIPHVPGMPGPGSLTPQMPLLPPPPQQ---------LQLPIPSSRGRSPN 1476
                      |..:||:.|.......|||     :.|....:         |:|.||.      .
Zfish   936 DVLSENTQLSTLQLTPVIHTDHPTTVGSL-----ICPSGAARAHYSSMSTGLKLEIPM------E 989

  Fly  1477 RKQPSPLLLGGGSGELKALSPFGGVQNVPSEFSRQP----PTPAQRQALQWNSKEAPKKAPFNFL 1537
            :.||             .::.....||:..:.:..|    |.|||...::.||     ..|::
Zfish   990 KDQP-------------YITHCHQHQNIGFDVTSNPEVLRPLPAQSIPVRLNS-----HLPYH-- 1034

  Fly  1538 RMADNVKTT-------EPEVRHFNLENVISGKQQELPLTPLHV--DTPNGNAPEETSPVASASAS 1593
              |.::.||       .|:      |...||......::...:  ..|:....:      |.|..
Zfish  1035 --AGSIYTTVSQTFFSRPQ------EPCCSGVSSVAVVSKYEIMDQQPDSERSD------SVSVG 1085

  Fly  1594 AKSKFLRPTSLPLKPGTFTPKRHHGITPTANTLPLISPETPRPSKSCVQ-------------LYL 1645
            |..:.|.|||                   :|.|   :||:.:..|...:             :.:
Zfish  1086 ATKRVLSPTS-------------------SNEL---NPESEQQQKRVKEEEENQENERRDDKVLI 1128

  Fly  1646 NGHAYTYLG-----------------LKCSTKMFYCTVNC--PQPSYVAGMHKLSMYSVWQVCEE 1691
            .......||                 |..:....:|.:|.  |.|| :....:.|:||.|.....
Zfish  1129 EFKKEEILGEQSVIFPTEHKDPPFQTLNTNLTFSWCFLNYIKPNPS-IQSEQQNSVYSSWCTSTR 1192

  Fly  1692 NQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQIVSSPSTSSTSSAFYQGP 1756
            | |:|.|...|::::|...|||     ..|.:.....:|.:|...|:...|...:.|.  .:...
Zfish  1193 N-PNPPGLTSKEMLSLLQCRQR-----HETLLYTMASMSPSLDVKQETPDSQKPNVTE--VHAAQ 1249

  Fly  1757 LKTPPTVTIAALSEANVAAKANEEAQAKKLETSPSGQPLVGGYESHEDYTYIRGRGRGRYVCSEC 1821
            |..|.....|.|:|........:|.|....:.|...|...|||.|.|:|.|:||||||||||.||
Zfish  1250 LTEPKEAQQAELTEVETKTTEEKEDQLSTSKCSSRVQICEGGYRSSEEYVYVRGRGRGRYVCEEC 1314

  Fly  1822 GIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPMPPDS 1886
            ||||||||||:||||.|||.||:.|.||||:|||||||||||:||.|.|:|.| |..|||:..:.
Zfish  1315 GIRCKKPSMLRKHIRLHTDARPYVCQHCNFAFKTKGNLTKHMKSKAHGKRCPE-GPAPGPVQCEL 1378

  Fly  1887 E----------FLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQK---- 1937
            |          ||:.:...:.|.|.         |.||| |:..||:.....|..|.|..|
Zfish  1379 ETDEGGDSAKHFLETEEVEEHQFSD---------AEESD-DEAEDNDEGDEQTSCSSSSSKWTSI 1433

  Fly  1938 -------------------EH---------------------------------EAARGLLS--- 1947
                               :|                                 :...|:.|
Zfish  1434 SRDDSGSCDILGLSNPGWEQHPKPPVSMSPRKPSHYGEASSPKTTKSIVTLLHLDPTTGMCSSPI 1498

  Fly  1948 ------LSMTPPIPQSVSPYPQLQDTPLPAASPANSIG-----SSGSQPKRLVCSFTSPKPPFDY 2001
                  |.|:|.:|||    |....:||...||..|:.     ||.|...|...||:
Zfish  1499 RSLSPGLQMSPALPQS----PGRDMSPLRCPSPRLSLSPSSCLSSLSPSDRSTSSFS-------- 1551

  Fly  2002 QKQEQYYSNPEESKPKRSVANEESAPMDLT------------KPRGSILLISPSPVSVPAHDLPK 2054
               |:..|...:..|.|  .:..|.|:.||            :||.| ...||:.:::      |
Zfish  1552 ---ERRVSPIRDLSPIR--PSSPSCPLALTVGASVTIQYQADRPRAS-TKASPNRLNL------K 1604

  Fly  2055 SQAQQMHDVIFGTSGNES-----GFMKTLISVSDKVRISAEMEEQAKHEAEGEDVQLQTYIKEHA 2114
            .:.::.|.....|:..:|     |            |:|..|:.:     ||:  ::.:::..|:
Zfish  1605 KKTEKTHSPHRRTNMTQSWPPAHG------------RLSRNMQPR-----EGQ--RVLSHLPLHS 1650

  Fly  2115 LHQAKI-----------------KQSQFSRSYLIN--------TLYT-----AASPV-----MSS 2144
            ..|..|                 :.:...||..:|        |:.|     ..|||     ..:
Zfish  1651 QPQVMIPNLSLTIPIGGIQMVQPRSNMLLRSTSLNHSVAQMTVTVLTKEKGAGRSPVGEVPHRKN 1715

  Fly  2145 SSTLFTANSRPVMSVNEVPSIE----VHEVKTPEAIESPRSAPEQAPVILAQIAQEENEE----P 2201
            ...:||..:..:.|.:|..|.|    :|.|...|.....:..|..|......|:|:.|.:    |
Zfish  1716 QLIVFTEPAVEMSSKSEASSDEDKEQIHGVVQAELFSRKKEVPSVAMTTWKSISQKNNRKHSRSP 1780

  Fly  2202 NIAEP 2206
            ...:|
Zfish  1781 KKTQP 1785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368	14/19 (74%)
		zf-H2C2_2	499..523	CDD:463886	16/23 (70%)
		C2H2 Zn finger	514..536	CDD:275368	14/21 (67%)
		PRK12323	<1185..>1269	CDD:481241	17/84 (20%)
		zf-C2H2	1816..1838	CDD:395048	19/21 (90%)
		C2H2 Zn finger	1818..1838	CDD:275370	17/19 (89%)
		zf-H2C2_2	1830..1855	CDD:463886	17/24 (71%)
		zf-C2H2	1844..1868	CDD:395048	18/23 (78%)
		C2H2 Zn finger	1846..1868	CDD:275370	18/21 (86%)
		zf-C2H2_8	<2305..2352	CDD:464935
		C2H2 Zn finger	2308..2328	CDD:275368
		zf-C2H2_jaz	2333..2359	CDD:432381
		C2H2 Zn finger	2336..2358	CDD:275368
		C2H2 Zn finger	2381..2403	CDD:275368
hivep3a	XP_005159605.1	C2H2 Zn finger	137..157	CDD:275368	14/19 (74%)
		zf-H2C2_2	150..174	CDD:463886	16/23 (70%)
		C2H2 Zn finger	165..185	CDD:275368	13/19 (68%)
		zf-C2H2	1309..1331	CDD:395048	19/21 (90%)
		C2H2 Zn finger	1311..1331	CDD:275368	17/19 (89%)
		zf-H2C2_2	1323..1348	CDD:463886	17/24 (71%)
		C2H2 Zn finger	1339..1357	CDD:275368	15/17 (88%)