Protein Alignment shn and hivep2b

DIOPT Version :10

• Sequence 1: NP_001260883.1
• Gene: shn / 36171
• FlyBaseID: FBgn0003396
• Length: 2587
• Species: Drosophila melanogaster
• Sequence 2: XP_005158638.1
• Gene: hivep2b / 100536055
• ZFINID: ZDB-GENE-130530-562
• Length: 1798
• Species: Danio rerio
• Alignment Length: 2135
• Identity: 467/2135 - (21%)
• Similarity: 748/2135 - (35%)
• Gaps: 664/2135 - (31%)

  Fly   328 QASG--DAVRTTSLSSNSSLSPPP---TTPLANGHHL--MTQQQSHQQVQQQQQQQQTPPPSVAI 385
            |:||  |.:|........|:||.|   ...||:|:.|  .:::|||.|::
Zfish    35 QSSGSEDKIRLAEQPQTPSVSPSPGIEPQVLASGNTLTSKSKEQSHVQLR--------------- 84

  Fly   386 HEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATLSPAS 450
                                            |...||.|.....
Zfish    85 --------------------------------RKNVPLPNKRYLQ-------------------- 97

  Fly   451 FAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHIRAHTNERPYPCD 515
             |:::.|:          ||.........|:|:||||||...|||||||:||||:||.||||||.
Zfish    98 -AEYEMLS----------GGLHKKEQKSVKTGKYVCQYCGRACAKPSVLKKHIRSHTGERPYPCI 151

  Fly   516 TCGIAFKTKSNLYKHCRSRSHAARARGLEVPADAD--------DGLSDQDAELSNSSSE-----L 567
            .||.:||||||||||.:|.:||.:| ||...::.|        :|....|||.|:.:.|     |
Zfish   152 PCGFSFKTKSNLYKHRKSHTHAVKA-GLVSVSEQDCKNTDEVAEGEMHSDAEQSSDTDEEVAEDL 215

  Fly   568 PSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSPAAGTLPPTTADNHHSATA 632
            .....|..:|...........|:..::.:..|.||.  .:..|.|..:.......||.   .|.|
Zfish   216 SLDTTSHIKETEGYVQEKVGKLAKKEALFPSQTPLK--KETGPSGKVSLWQFREMTAP---VAIA 275

  Fly   633 QHRQSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQI---------------QQQQQQHQLAQQK 682
            |..|.:::...|.|.    ....|.|:.|:..|.|.:               :.:..:.|:.|..
Zfish   276 QIDQMVEFSTIKQKL----ALRLSEKKSQESDQSLSLPSSYSKGSTDSGYFSRSESAEQQINQSS 336

  Fly   683 LSIQLPLVQQPSLAHPTLSPSTQMKMKHHINSHQIQLQLQQQQSLLAQQSLLAAMPPGGVYYLGQ 747
            .|.:   ..|..:......|:|:.|....:.:....:.......::   :|...|.||
Zfish   337 ASAK---SYQEIMFGKCYRPATRPKQSITVQTCMTDINEATSSFMI---TLNKGMMPG------- 388

  Fly   748 PSYYNQDTAAAIHQHAL-AIQQFQIHLAQQQQQQQQQHPPLVKATPPMQQPPS------LPPQQL 805
                  ||.::||:... .::..:|.....|::..|:          .|.|.|      |.....
Zfish   389 ------DTDSSIHRSKKDLVRSIKIDSESFQEEDYQE----------CQIPSSDLLETALESSVF 437

  Fly   806 VRANSQISSVATAPATPTPAANLSTFASSSGGKQVNVAKVQ-----------EHI---------- 849
            :|:||..:|..:...||....:.::|.....|..|......           ||.
Zfish   438 LRSNSLPTSSKSNLNTPQGLRSSNSFDERMTGADVTYRGAMGMRRLMRQSAFEHSANEGHAESDC 502

  Fly   850 -------------------SKLISQN-------------------------EAIVENKEILLQKK 870
                               ||:.::|                         :.:.|.::..:|.|
Zfish   503 YTHLACSLKSDLKIHSIDDSKMAAENFQETETCSVCPGHSSESSTRKRRKDKTVTEEEDFHIQDK 567

  Fly   871 YPKQL--------SRSRSFNNANSNNASQHGSNA-SALHANNSQNNTNAQMPERETKVNLAQAIF 926
             |..:        ::..|.::..|:...:.|||. |.:...||.|           ::|.|:.:.
Zfish   568 -PSNVTGLSEDLETKQISSDSVVSDTERKAGSNVISVIQHTNSLN-----------RLNSAEKLS 620

  Fly   927 QKQQHQLQQQQQQQITQQQQQQLEQQNYYT----------YIQQQQECQQQQLEPPNGVVKRNAY 981
            :.:.|||     .:|.:..::....:.:.|          ::.|:....:|....||..|
Zfish   621 EVRSHQL-----DKIGKFMEKGHSMECHRTGSECQWGPCGFLHQKLHMHKQPTSQPNIQV----- 675

  Fly   982 KPGVVMTTPVKQQQQLPPPPSPLPMQTMQYR-------QDPATPVTKIEQPTTAVPVMPLNLSAK 1039
             |.:.:|..       |..|..:|...::.|       |.|....|..:.|...:|      ..|
Zfish   676 -PEIRVTVE-------PDRPEKVPDVGVKQREKHTEEFQWPQRSETLSQFPMEKLP------PKK 726

  Fly  1040 PKPTLVTVPVSSLSTS------SLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAVP 1098
            .:..|..:..||..:|      ||:.:|:..:|.:.||       ..:.|:.:...||......|
Zfish   727 KRLRLAEMECSSGESSFESACTSLSRSPSQDSNLSHSS-------SFSQSLDREETLNLVSQINP 784

  Fly  1099 IGEGDDAVYSCPICASEFRSA-DDLKLHNSTYCQDASSSAPMSPAS--SPFRSNSISLSLPELKS 1160
                |::  |.|:   ||.|. ...:.|:....:.||..||....|  :.|||          ||
Zfish   785 ----DES--SKPL---EFLSVPGSSQSHHREMRRSASEQAPYKLPSEIAEFRS----------KS 830

  Fly  1161 HMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTSTVTAPTVTASAPAPAVATVTAPSS 1225
            ....|.:|.|..:|  .::|.:|.:.::.:.|.:..|.......:..::.....|         .
Zfish   831 FDYGSLSPSSTYRL--EEVKERRRAFLVRQASLSGEPETQGGNFSDEISKRTTLP---------F 884

  Fly  1226 APAPQIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRI 1290
            .|...||.:|:         .|:..:....:.|.|.
Zfish   885 TPEGSIEKMRY---------SLISGSSFPHHRQYSP----------------------------- 911

  Fly  1291 KTSDLVVASSSQ--QPTSFNFSFNNQNSSNSVPELQSSKEERLRRFTSSGGSMIPISECPDLDNS 1353
                  |.||||  :||..|           |.::::              .|:.|.:.|:...|
Zfish   912 ------VQSSSQHVKPTVCN-----------VHDMEN--------------VMLVIKKEPEESKS 945

  Fly  1354 PKM---IRTPLLSGGSFQDVSVKVNNETGS---SSKERKLMALVSGSGLLGVSSGPQHFQFPPIN 1412
            |:.   :|.|.      :|.|..:.|...:   .|:.::.:|....||||    .|...|.
Zfish   946 PETYVNLREPQ------EDCSQSLGNVLSTIAVLSQAQQALASQCSSGLL----VPVRIQM---- 996

  Fly  1413 SITAFNPLTLPPMS---GGDKTTPVTPIPHVPGMPGPGSLTPQMPLLPPPPQQLQLPIPSSRGRS 1474
            .:.::..:|...:|   ......|::.:.|...    .|.:.|:..|...|.:|:..||.|....
Zfish   997 QVPSYGNITYTSISHILDSHIQKPISCLEHKKS----SSQSQQLHSLQASPAKLKTGIPLSLTSK 1057

  Fly  1475 PNRKQPSPLLLGGGSGELKALSPFGGV--------------QNVPSEFSRQPPTPAQRQALQWNS 1525
            ......:|   .||:.: :.|||...:              :|:..:...      :..|::..:
Zfish  1058 TISTTEAP---SGGANK-RMLSPASSIELFIEAKQQKRVKDENIYGQIVE------ELSAVELGN 1112

  Fly  1526 KEAPKKAPFNFLRMADNVKTTEPEVRHFNLENVISGKQQELPLTPLHVDTPN----GNAPEETSP 1586
            .|..|::|.:                .|..|          |:..:.:|...    .||..::|.
Zfish  1113 LEVEKESPKS----------------EFTSE----------PIDKMDMDEATQEFYSNAELQSSA 1151

  Fly  1587 VASASASAKSKFLRPTSLPLKPGTFTPKRHHGITPTANTLPLISPETPRPSKSCVQLYLNGHAYT 1651
            ..|..|:...:...|.|:...        ||                   |.||:.|..:....|
Zfish  1152 RISQDAAIMEQKPTPESMMAS--------HH-------------------SASCISLMPSAITGT 1189

  Fly  1652 YL-----GLKCSTKMFYCTVNCPQPSYVAGMHKLSMYSVWQV-CEENQPHPLGFKLKQVMALYDS 1710
            .|     ||..:|.|.:|.:|..:|:....:...|.|:.|.| |  :.|:|.......|:||..|
Zfish  1190 LLFSKFPGLHTTTCMSWCYLNTTKPNSTHTVAPFSEYASWFVRC--HNPNPPDISTGMVLALLRS 1252

  Fly  1711 RQRMLGNGSSTAMAGSGKLSYNLVASQQIVSSPSTSSTSSAFYQGPLKTPPTVTIA--------- 1766
            :|:                ..|.:.:...:..|....||:.:      ||....||
Zfish  1253 KQQ----------------RQNAIYTIATIYQPGLLVTSTPW------TPKQEQIALDYREEDTK 1295

  Fly  1767 ---ALSEANVAAKA-NEEAQAKKLETSPSGQPLV-GGYESHEDYTYIRGRGRGRYVCSECGIRCK 1826
               .|.|.:...|: .|:..:...:|.|....:. |||:|:|:|.|:||||||:|:|.|||||||
Zfish  1296 QDIRLREISHRGKSLREDVSSIIRQTEPMRVKIFEGGYKSNEEYVYVRGRGRGKYICEECGIRCK 1360

  Fly  1827 KPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINP------------ 1879
            |||||:|||||||||||:.|..|||:|||||||||||:||.|.|||:|||::|
Zfish  1361 KPSMLRKHIRTHTDVRPYICKCCNFAFKTKGNLTKHMKSKAHMKKCLELGVSPTAMDNTEDADDT 1425

  Fly  1880 ----GPMPPDS----EFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQ 1936
                |.||.:.    :|.||:              .|..|.|.:.|:..|:|.:...|.::.||.
Zfish  1426 QKSLGIMPAEQTIKHQFSDVE--------------DSDGADEDEPDEDEDDECDGDSTPKTLSRS 1476

  Fly  1937 KEHEAARGLLSLSMTPP-----IPQSVS-----PYPQLQDTPLPAASPANSIGSSGSQPKRLVCS 1991
            ...:      |.::..|     :|:...     |..||:.:.|......||..||        ||
Zfish  1477 TSPQ------SYAVNKPCMSGCLPKHFDSGCNLPKEQLEASSLTIEDDLNSDQSS--------CS 1527

  Fly  1992 F--TSPK---PPFDYQKQEQYYSNPEESKPKRS-VANEESAPMDLTKPRGSILL---ISP----S 2043
            |  ..|:   |.:|..:| :|.|...:..|:|. :::.:|:|:....||..:.:   .||    |
Zfish  1528 FELCPPQLLSPCWDSPRQ-RYMSPRGDLSPQRHLLSSRDSSPLRAVSPRRDLSIRGDFSPIRQLS 1591

  Fly  2044 PVSVPAHDLPKSQAQQ---MHDVIFGTSGNESGFM--KTLISVSDKVRISAEMEEQAKHE--AEG 2101
            ||.....|....:||.   .|.|.........|..  :|.:.:...||..|........|  .:.
Zfish  1592 PVRPTGLDTSGQRAQSPLGRHKVALRAVSPRRGSYQHRTHMDLGRSVRFQASPIRPIIGETGVDQ 1656

  Fly  2102 EDVQL------------------QTYIKEH-ALHQAKIKQSQFSRSYLINTLYTAASPVMSSSST 2147
            .|..|                  |..|..| .||    .|.|.|....:..:.....|.:|:|..
Zfish  1657 GDTSLNLIVPVGLCSSKDLPKTRQPDIFSHLPLH----SQGQVSTPVPMVPIGVLRMPSISTSGA 1717

  Fly  2148 LFTANSRPVMSVNEVPSIEVHEVKTPEAIESPRSAPEQAPVILAQIAQEENEEPN 2202
            :...||.|     .:|...:.|...|.  ::..|.|:.|.....:||......||
Zfish  1718 VAERNSLP-----SIPQGNILETAAPG--QTSASVPDPAVAYSGEIATYSTGLPN 1765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368	15/19 (79%)
		zf-H2C2_2	499..523	CDD:463886	16/23 (70%)
		C2H2 Zn finger	514..536	CDD:275368	14/21 (67%)
		PRK12323	<1185..>1269	CDD:481241	10/83 (12%)
		zf-C2H2	1816..1838	CDD:395048	18/21 (86%)
		C2H2 Zn finger	1818..1838	CDD:275370	17/19 (89%)
		zf-H2C2_2	1830..1855	CDD:463886	18/24 (75%)
		zf-C2H2	1844..1868	CDD:395048	17/23 (74%)
		C2H2 Zn finger	1846..1868	CDD:275370	17/21 (81%)
		zf-C2H2_8	<2305..2352	CDD:464935
		C2H2 Zn finger	2308..2328	CDD:275368
		zf-C2H2_jaz	2333..2359	CDD:432381
		C2H2 Zn finger	2336..2358	CDD:275368
		C2H2 Zn finger	2381..2403	CDD:275368
hivep2b	XP_005158638.1	zf-C2H2	120..142	CDD:395048	17/21 (81%)
		C2H2 Zn finger	122..142	CDD:275368	15/19 (79%)
		zf-H2C2_2	135..159	CDD:463886	16/23 (70%)
		C2H2 Zn finger	150..170	CDD:275368	13/19 (68%)
		zf-C2H2	1350..1372	CDD:395048	18/21 (86%)
		C2H2 Zn finger	1352..1372	CDD:275370	17/19 (89%)
		C2H2 Zn finger	1380..1398	CDD:275370	14/17 (82%)