DRSC/TRiP Functional Genomics Resources

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Protein Alignment shn and hivep2

DIOPT Version :9

Sequence 1:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster
Sequence 2:XP_002937260.1 Gene:hivep2 / 100495428 XenbaseID:XB-GENE-485854 Length:2376 Species:Xenopus tropicalis


Alignment Length:2623 Identity:553/2623 - (21%)
Similarity:900/2623 - (34%) Gaps:865/2623 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 SNSSIINSQQTTVNATP-------ATDEAPLGDRS-------NISRYLHKK-------FKRLAST 312
            |..||:..:.|:.:..|       ..|.:||..|:       .|...:|.:       |..|..|
 Frog     3 SGDSILGQEATSRSRDPDRIRSRWTQDSSPLVTRNTYSSQEREIQPQIHSERIGNPQHFSSLKVT 67

  Fly   313 TEVDSWSATNGGGALQASGDAVRTTSLSSNSSLSPPPTTPLANGHHLMTQQQSHQQVQQQQQQQQ 377
            :::|                   |..:        |........|...|.:.||...|....||:
 Frog    68 SQID-------------------TAHI--------PEKQYTQKRHGSYTPRHSHSFPQHTLHQQR 105

  Fly   378 ----TPPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGRTRTPLANSNSNTNSTSNSNS 438
                .....|.:::|      .:|:..:..|:......|.::|..:|..::..:|..:..|..:.
 Frog   106 LVHSAKSLEVPVYQF------HSHLQPVPSEDLFFQMHGGQSASFSRKKISGLSSTYSQYSQKSL 164

  Fly   439 NHAANATLSPASFAQHQQLTQPTTVSPGIPGGAAAPNPACEKSGRYVCQYCNLICAKPSVLEKHI 503
            ..:.::         |::..:|                  :|.|:|:|.||...|||||||:|||
 Frog   165 ESSEDS---------HKKEQKP------------------KKPGKYICPYCTRACAKPSVLKKHI 202

  Fly   504 RAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAARARGL------------------------- 543
            |:||.||||||..||.:||||||||||.:|.:||.:| ||                         
 Frog   203 RSHTGERPYPCVPCGFSFKTKSNLYKHRKSHAHAIKA-GLVPFTDSAVSRLDLDAACIDVETEIH 266

  Fly   544 ---EVPADADDGL-------SDQDAELSNSSSEL---------PSRAGSPYEEPI-NSPTPSPST 588
               |...|.||.|       |....:|::.|.|:         ...:|.|.:.|| ..|.|. |.
 Frog   267 SDGEQSTDTDDDLLLGPEKSSPIQLDLTSRSGEILDSGFHTSSEESSGGPIKVPILIIPKPG-SQ 330

  Fly   589 LSAAKSAYIQQPPLP-----------TYMQQLPL---------GSPAAGTLPPTTADNHHSATAQ 633
            :|:..|.:|....|.           |..|:|.|         ...::..|.|.:..:..|....
 Frog   331 VSSENSTFISSDLLANHVTSKADESHTVRQKLALKLTENKGQNSEKSSNLLSPHSKGSTDSGYFS 395

  Fly   634 HRQSIDYKPYKPKFHNASLY-------------SCSSKE----------LQQQQQQLQIQQQQ-- 673
            ..:|.: :|..|...||:.|             |.:|:|          .::...||..::|.  
 Frog   396 RSESAE-QPISPPNTNATSYEEIMFGKFCRPRSSLTSQEANLSVVNPSMTEENISQLITKRQNVS 459

  Fly   674 ---------------------QQHQL----AQQKLSIQLPLVQQPS--LA---HPTLSPSTQM-- 706
                                 .::||    |:.:..:...:..|||  ||   ..||:.|..|  
 Frog   460 DPSKFRSLKSSRFTGFHTSEFSKNQLIADSAESENKLYSEIQAQPSGLLAAGDASTLTRSNSMPT 524

  Fly   707 -----------KMKHHI------------------NSHQIQLQLQ-------------------- 722
                       |...|.                  |.||..|:.|                    
 Frog   525 CSGTNLSIPPNKRGSHSFDERITGSDDVFYPGTGGNPHQRFLRRQGAFELAGEGHSEFDPYARVP 589

  Fly   723 ------------QQQSLLAQQSLLAAMPPG--GVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHL 773
                        .:::||.|:..:|   ||  |:|.|         :.:|:.|     :::....
 Frog   590 KNAVFSYHRKTAHEKNLLPQEKKMA---PGERGIYDL---------SISAVQQ-----KRWDDFE 637

  Fly   774 AQQQQQQQQQH---------------PPLVK-------------------ATPPMQQPPSLPPQQ 804
            |.:|..::.|.               |||.:                   ...||......|...
 Frog   638 AYKQGYRESQFISGIKSGEFFIDVTAPPLSRFGITVENRKRRKEKSVGDEEDIPMGCSLGSPMHS 702

  Fly   805 LVRANSQISSVATA-----------PATPTPAANLSTFASSSGGKQVNVAKVQEHISKLISQNEA 858
            .:...||:..:|..           ..:..|....|.|...||    :...:.:..|....:|..
 Frog   703 DLDIKSQLQEIARGGLVVSGQEYPYSGSQEPFDIASRFHHQSG----SPISILDESSLDPDKNAE 763

  Fly   859 IVENK---EILLQKKYPKQLSRSRSFNNANSNN--ASQHGSNASALHANNSQNNTNAQMPERETK 918
            :|..|   .::...::...|||..||..:.|..  |.|....:|...|.:|.|..::..||....
 Frog   764 LVSKKPPGNVISVIQHTNSLSRPNSFERSESTELLACQQDKPSSPSEACDSGNTMSSISPEWTQS 828

  Fly   919 VNLAQAIFQKQQHQLQQQQQQQITQQQQQQLEQQNYYTY--IQQQQECQQQQLEPPNGVVKRNAY 981
            ..:|..    .......||.||.......:|.:|:..|.  |:..:|..:.:.||          
 Frog   829 GEIADT----SGRPSPSQQSQQSAYHMPPRLVRQHNITVPEIRVTEEPDKPEKEP---------- 879

  Fly   982 KPGVVMTTPVKQQQQLPPPPSPLPMQTMQYRQDPATPVTKIEQPTTAVPVMPLNLSAKPKPTLVT 1046
                  ..|||:.:: ||.....|.::....|.||..:.                ..|.:..|..
 Frog   880 ------EIPVKEPEK-PPEEFQWPQRSETLSQLPAEKLP----------------PKKKRLRLAD 921

  Fly  1047 VPVSSLSTS------SLAPTPTTSTNPTSSSKTA-----PPPAQVNNSIIKNLLLNARGLAVPIG 1100
            :..||..:|      ||:.:|:..:|.:.||..:     ....:|:....::.:..|..|.||.|
 Frog   922 MDNSSGESSFDSTGTSLSRSPSQESNLSHSSSFSMSFDREEILKVSTFTKQDEIKQAEFLTVPPG 986

  Fly  1101 EGDDAVYS---------------------CPICAS--EFRSADDLKLHNSTYCQDASSSAPMSPA 1142
            .     ||                     ||....  |.|| ......|.|:   ||:|...:..
 Frog   987 S-----YSLSVPGQPHHKEMRRSSSEQIPCPSLTEIPEIRS-KSFDYGNLTH---ASASGATTTT 1042

  Fly  1143 SSP---------FRSNSISLSLPE---LKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLS-AA 1194
            .||         .|..|.| ..||   .:...|.::.|.....:.      :|||.:....| .:
 Frog  1043 LSPNRERKKCFLVRQASFS-GFPENTQTEQETAGNQEPSEQTHIC------RRSSQIPWHHSPPS 1100

  Fly  1195 QTPARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPG---PLLGKTPLVDY 1256
            ..|..||.::..|...     .:.|...|:::.:...         |.|.|   |||.:||.:  
 Frog  1101 SLPGSTSVLSEDTGNV-----LIGTSAQPTTSTSSHY---------LQSAGSHDPLLHQTPYI-- 1149

  Fly  1257 AQQSTPRKAQDSVVITKMHEDRQFVIEAQPAKRIKTSDLVVASSSQQPTSFNFSFNNQNSSNSVP 1321
                 |::.......|.:|.::........|.::..|.:.:|   |.|....|.:     ...|.
 Frog  1150 -----PKRHLQDQQSTFIHPEKTVYPPVHNAFQLPYSSVCMA---QLPIHHPFMW-----PTCVD 1201

  Fly  1322 ELQSSKEERLRRFTS----------------------SGGSMIPISECPDLDNSPKMIRTPLLSG 1364
            .||...|..|::...                      :||.  |:|               .|.|
 Frog  1202 PLQRHFEHHLQQLQKTYFKQPSQSTIHSYYLDPAQELTGGK--PVS---------------YLHG 1249

  Fly  1365 G-----SFQDVSVKVNNET----------GSSSKERKLMALVSGSGLLG-VSSGPQ-----HFQF 1408
            |     ::.:.|...:..|          |||....:.:.:||.|...| :.:|..     |...
 Frog  1250 GEKGYHAYLETSAHRSKNTVSKLQRDHSGGSSDSTDQSLQIVSVSQSTGSLQTGTVVPVRIHTHV 1314

  Fly  1409 PPINSI--------------TAFNPLTLPPMSGGDKTTPVTPIPHVPG-------MPGP-GSLTP 1451
            |...|:              |:..|:.:..:.|......:.....:.|       |.|| |::  
 Frog  1315 PSYGSVMYTSISQILVTHAQTSNPPIVICKVDGSTSQRTLATNASMKGFGFSIAQMLGPCGAI-- 1377

  Fly  1452 QMPLLPPPPQ-QLQLPIPSSRGRSPNRKQPSPLLLGGGSGELKALSPFGGVQNVPSEFSRQPPTP 1515
            :.|:...||. .|...||.....:.:    |....|||.   :.|||...:: :..|..:|....
 Frog  1378 EHPIWKVPPTFDLDSAIPLCLASNSD----SVATFGGGK---RMLSPASSLE-LFMETKQQKRVK 1434

  Fly  1516 AQR---------QALQWNSKEAPKKAPFNFLRMADNVKTTEPEVRHFNLENVISGKQQE----LP 1567
            .:|         .|::..:.:..|          |..:|::|::       |..|:..|    ||
 Frog  1435 EERMYGQIVKELSAVELTNSDIKK----------DLTRTSKPQL-------VRQGRTTEQKDNLP 1482

  Fly  1568 -----LTPLHVDTPN------GNAPEETSPVASAS-------ASAKSKFLRPTSLPLKPGTFTPK 1614
                 ..||..|:|.      ..:....||....|       .:|.:..|.|.|.|.:.....|.
 Frog  1483 SIGTSSPPLSSDSPQSILLDVAESKSSDSPEGRMSPDELYDEETASNMSLSPQSTPSEFFEEDPL 1547

  Fly  1615 RHHGITPTANTLPLISPETPRPSKSCVQLYLNGHAYTYLGLKCSTKMFYCTVNCPQPSYV-AGMH 1678
            :.|..:.:...|.|:...|..|.|...:|:   :...:..|:..|.:.:|.:|..:||:| ....
 Frog  1548 KSHKPSVSILDLSLVDGATIGPIKDGTELH---NILQFPSLRTLTTVSWCFLNYAKPSHVEQATL 1609

  Fly  1679 KLSMYSVWQVCEENQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMA---GSGKLSYNLVASQQIV 1740
            |.|:|:.|.:...| |:|.|...:..:||..|:|:......:.|..   |:|||:.:.|...|..
 Frog  1610 KSSVYASWCISSCN-PNPSGLNTRTSLALLRSKQKNTVEIYTVAAMNRFGAGKLTSSNVWKHQFA 1673

  Fly  1741 SSPSTSSTSSAFYQGPLKTPPTVTIAALSEANVAAKANE----EAQAKKLETSPSGQPL-----V 1796
            .               :|...::.:::..|..||..:.|    |:..:|..::...:|:     .
 Frog  1674 Q---------------MKLEASLLVSSKLEKKVAGISKERTKGESHGEKDISAKQTEPMRIKIFE 1723

  Fly  1797 GGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTK 1861
            ||::|:|||.|:||||||:|:|.||||||||||||||||||||||||:.|..|||:|||||||||
 Frog  1724 GGFKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNLTK 1788

  Fly  1862 HMQSKTHFKKCIELGINPGPM----PPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDN 1922
            ||:||.|.|||:|||:....:    ..:|..:: |...|.:.|:.|.....|.|.|||.||..||
 Frog  1789 HMKSKAHMKKCLELGVAMTSVDDADAEESGSIE-DTQKDSEKSSPAIDHQFSDAEESDVDDGDDN 1852

  Fly  1923 ESESSDTDESKSRQKEHEAARGLLSLSMTPPI-PQSVSPY-PQLQDTPLPA------ASPANSIG 1979
            |.|..|.::....|.:           :||.. .:|.||. |:....|:.|      |||..|||
 Frog  1853 EDEDDDDEDFDDNQGD-----------ITPKTRSRSTSPQPPRFSTLPVTATLASQRASPETSIG 1906

  Fly  1980 SS------GSQP---------KRLVCS-------------------------------------- 1991
            .|      .:.|         |..:|.                                      
 Frog  1907 HSSLMSYLSTMPSIQITHLMTKNAMCGDSQMMEYQRLFLPDLEHDRGKMDVPVGMDEDFMLTSEP 1971

  Fly  1992 FTSPK----------PPFDY-----QKQEQYYSNPEESKPKRSVA-NEESAPMDLTKPRGSILL- 2039
            .:|||          |.:|.     ...::|.|...:..|:|.:: ..:::|:....||....: 
 Frog  1972 SSSPKDFSSCSRHSSPGYDSSPCRDNSPKRYLSLRGDMSPRRHLSPRRDASPLRHLSPRKEAAIR 2036

  Fly  2040 --------ISP-------SPVSVPAHDLPKSQAQQMHDVIFGTSGNESGFMKTLISVSDKVRI-- 2087
                    :||       .||| |..||...:     |:   :...|..:|.|..::|.:.|:  
 Frog  2037 RELSPRRDVSPRRHLSPLRPVS-PGKDLSSGR-----DI---SPRRERKYMATFRALSPRRRLHH 2092

  Fly  2088 ------------------------------SAEMEEQAKHEAEGEDVQL-QTYIKEH-ALH---- 2116
                                          |...|....|::.|:.::. :.|:..| .||    
 Frog  2093 NSSLPITHYLHSDSGFLGQGRRNWPQVPYTSPHPETILGHQSPGQTLEAHRDYVFSHLPLHSQQQ 2157

  Fly  2117 -QAKIKQSQFSRSYLINTLYTAASPVMSSSSTLF--TANSRPVMSVNEVPSIEVHEVKTPEAIES 2178
             :|.:.........:|::..|..|...||::.|.  :::.:..||:...|||.:|..:....|..
 Frog  2158 VRAPLPMIPIGGIQMIHSNSTIQSSSHSSATHLHERSSDEKRSMSLESCPSIPLHLDEHSSNISL 2222

  Fly  2179 PRSAPEQAPVILAQIAQ---EENEEPNIAEPHNANLPAAVQQPDVNEFTGVLGNPTAPPTSSVTA 2240
            ..|:.|.....|..:.|   :|:.:|...|          |:.::...           |.::..
 Frog  2223 KDSSSESDSTCLPSLGQSPTDESSQPTERE----------QEENIRTC-----------TKAIAC 2266

  Fly  2241 TSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGFKSSTPTSKSGDLQHVSYGRGVPPAPIAGDAR 2305
            ..::|....|......:...:|.|:|           :..|:.| ::|.|   |:.    ||.|.
 Frog  2267 LRIATEDGLPQKRDLLSRPPEPNQKT-----------SECSQLG-IRHFS---GLE----AGTAL 2312

  Fly  2306 PTCTMCSKTFQRQHQLTLHMNIH 2328
            .:.:            |.|:::|
 Frog  2313 ASAS------------TTHVDLH 2323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 14/19 (74%)
zf-H2C2_2 499..523 CDD:290200 16/23 (70%)
C2H2 Zn finger 514..536 CDD:275368 14/21 (67%)
zf-C2H2 1816..1838 CDD:278523 19/21 (90%)
C2H2 Zn finger 1818..1838 CDD:275370 18/19 (95%)
zf-H2C2_2 1830..1855 CDD:290200 19/24 (79%)
zf-C2H2 1844..1868 CDD:278523 17/23 (74%)
C2H2 Zn finger 1846..1868 CDD:275370 17/21 (81%)
zf-C2H2 2307..2328 CDD:278523 2/20 (10%)
C2H2 Zn finger 2308..2328 CDD:275368 2/19 (11%)
zf-C2H2_jaz 2333..2359 CDD:288983
C2H2 Zn finger 2336..2358 CDD:275368
C2H2 Zn finger 2381..2403 CDD:275368
hivep2XP_002937260.1 C2H2 Zn finger 185..205 CDD:275368 14/19 (74%)
zf-H2C2_2 198..222 CDD:290200 16/23 (70%)
C2H2 Zn finger 213..233 CDD:275368 13/19 (68%)
zf-C2H2 1743..1765 CDD:278523 19/21 (90%)
C2H2 Zn finger 1745..1765 CDD:275370 18/19 (95%)
zf-H2C2_2 1757..1782 CDD:290200 19/24 (79%)
C2H2 Zn finger 1773..1791 CDD:275370 14/17 (82%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11036
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm48789
Panther 1 1.100 - - O PTHR45944
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3898
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.130

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