Protein Alignment shn and hivep1

DIOPT Version :10

• Sequence 1: NP_001260883.1
• Gene: shn / 36171
• FlyBaseID: FBgn0003396
• Length: 2587
• Species: Drosophila melanogaster
• Sequence 2: XP_002932729.3
• Gene: hivep1 / 100491039
• XenbaseID: XB-GENE-479002
• Length: 2591
• Species: Xenopus tropicalis
• Alignment Length: 2772
• Identity: 578/2772 - (20%)
• Similarity: 944/2772 - (34%)
• Gaps: 957/2772 - (34%)

  Fly   235 RDKASLSDS---------------KMTLQQM---AAVSSNQEPVAPNVANTMSNSSIINSQQTTV 281
            :||..|.|.               ::|::.:   |::.:.:..|.|::.|.....:.::|:||..
 Frog    96 KDKQCLLDQLRKKDIKETKVGERLELTVKPVKSGASMQAKKLSVPPDLCNGRREDNDMDSKQTLS 160

  Fly   282 NATPATDEAPLGDRSNISRYLH-KKFKRLASTTEVDSWSATNGGGALQASGDAVRTTSLSSNSSL 345
            ..|.:::   ||...:.:..|. ||.....|..:|          .|:|....:      ||.:.
 Frog   161 RQTISSN---LGSTKSANINLEIKKCSTANSAFDV----------LLRAMEPEL------SNLNQ 206

  Fly   346 SPPPTTPLANGHHLMTQQQSHQQVQQQQQQQQTPPPSVAIHEFSANFVNSNHVNAIGHEESIISN 410
            |.||.:       ..|::|.|...    .:..|..|||:..||||.:|..:|    |.:.|..|.
 Frog   207 SWPPCS-------TQTKKQGHTVA----PETTTSNPSVSQSEFSARYVVYHH----GDQSSQTSQ 256

  Fly   411 SGYKAAGRTRTPLANS----NSNT--------------NSTSNSNSNHAA-NATLSPASFAQHQQ 456
            | .|.:...:..|...    ||:|              .||.|....|.| |::::..|.:..|.
 Frog   257 S-VKGSSNVQDQLGTEHEKCNSDTGLQNMHSSGFSSSLESTKNQQVYHVALNSSIADPSSSLTQV 320

  Fly   457 LT-QPTTVSPGIPGGAAAPNP--------------AC---------EKSGRYVCQYCNLICAKPS 497
            |: |..|.||......:..:|              .|         :|.|:|:|:||:..|||||
 Frog   321 LSLQGNTSSPANNSNVSVNSPYSLAQVASLIGGEQMCNIVLKDQKPKKQGKYICEYCSRACAKPS 385

  Fly   498 VLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAAR------------------ARGLE 544
            ||.||||:||.||||||.|||.:||||||||||.:|.:||.:                  .:.|.
 Frog   386 VLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHAIKLGLGLRTDSGGMLLSHDSEKALC 450

  Fly   545 VPADADDGLSDQDAELSNSSSE---LPSR----AGSPYE---EPINSPTPSPSTLSAAKSAYIQQ 599
            :.:|.|:.....|..:|....|   :|.|    ..:.:|   :...|..||.|.:|.::: |:|.
 Frog   451 IHSDVDESGESDDEYISEERQEDQNVPERECIKRSNDFERVPQIKESNIPSNSQVSVSQN-YLQG 514

  Fly   600 PPLPTYMQQLPL-------GSPAAGTLPPT--TADNHHSA------TAQHRQSIDYKPYKPKFHN 649
            ..:...:.:||.       .||.....|..  :|..|:.|      |.:..|::
 Frog   515 KGVEARLTELPKVVVYPVNASPLRADSPKVLESASEHYVAQIPELNTQKKNQNV----------- 568

  Fly   650 ASLYSCSSKELQQQQQQ----LQIQQQQQQHQLAQQKLSIQLPLVQQPSLAHPTLSPSTQMKMKH 710
              |..||..|::|...:    .:|..:|
 Frog   569 --LPVCSLTEMEQSSYKTCEFTEIDDKQ------------------------------------- 594

  Fly   711 HINSHQIQLQLQQQQSL-LAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLA 774
             ::|.....|||:||:. .:|:.....:.|..   ||     :.|:.               :.:
 Frog   595 -VSSTTCHAQLQRQQATDYSQEQPKCLLSPRS---LG-----STDSG---------------YFS 635

  Fly   775 QQQQQQQQQHPPLVKATPPMQQPPSLPPQQLVRANSQISSVATAPATPTPAANLSTFASSSGGKQ 839
            :.:...|...||    ||.::..||....    .:..::||....||..|..           :|
 Frog   636 RSESVDQAMSPP----TPFLKLLPSSEKD----FSKNLNSVTQINATVMPLV-----------QQ 681

  Fly   840 VNVAK----------------VQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANS-- 886
            |.|.|                ::|.||||||.|||:|::|::...|.....|||..|.::..|
 Frog   682 VYVEKPTVITGAMRPPLGTKTLEERISKLISDNEAVVDDKQLDSVKPRRTSLSRRGSIDSPKSYI 746

  Fly   887 -NNASQHGSNASALHANNSQNNTNAQM-PERETKVNLAQAIFQKQQHQLQQQQQQQITQQQQQQL 949
             .::.|..........::|.:...:.. |..::|    |..|.....|........||:....
 Frog   747 FKDSFQFDLKPVGRRTSSSSDIPKSPFTPTDKSK----QVFFLSVPSQFTSMDCLPITRSNSM-- 805

  Fly   950 EQQNYYTYIQQQQECQQQQLEPPNGVVKRNAYKPGVVMTTPVKQQQQLPPPPSPLPMQTMQYRQD 1014
                                 |..|.   :|..|.:..:.|::.........|.|....  :...
 Frog   806 ---------------------PTTGY---SAVPPVMPTSHPLRGSHSFDEKISSLCDDV--FVSG 844

  Fly  1015 PATPVTKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTSSLAPTPTTSTN-PTS--SSKTAPP 1076
            |:|| .::..|.|.|....:..|            |:.....|.|..:...| |.|  ||:...|
 Frog   845 PSTP-QQVAHPRTLVRQAAVEDS------------SATEHFGLGPARSVDENYPGSKVSSEVLLP 896

  Fly  1077 PAQ--VNNSIIKNLLL--NARGLAVPIGEGDDAVYSCPICASEFRSADDLKLHNSTYCQDASSSA 1137
            .::  |..|.:..:..  |.||          .::.|..|.:.:|..::.:.|...||.:.....
 Frog   897 RSKSFVQGSSVDRIKKSHNGRG----------TMFECETCRNRYRKLENFENHKKFYCSELHGPK 951

  Fly  1138 PMSPASSPFRSNSISLSLPEL-----KSHMANSKNPLSLAKLA---------------------- 1175
            ..:....|..|.:::.|.|::     .:.....:.||.:.|..
 Frog   952 SKTVGREPEHSTTMNTSQPQIFHYRVAASTGTLEQPLQIRKRRKMKSVGDDDEPQQIDSNTAPEN 1016

  Fly  1176 WSQLK----TKRSSLV-------------------LSRLSAAQTPARTST-------VTAPTVTA 1210
            ...||    ||.||.:                   ::|.:...|..:|||       |:...|..
 Frog  1017 MDALKNSRSTKNSSTITILGSQSCSVSTVSPQIHLVARSTDPSTEIKTSTLDKNKNVVSQERVEV 1081

  Fly  1211 SAPAPAVATVTAPSSAPAP-QIEALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQDSVVITKM 1274
            ......::.:...:|...| ..|.:..|:...|:         ::...|:|.|.....:||   .
 Frog  1082 KCQGTGISVIQHTNSLSKPSSFEKIDSVERNSPA---------ILHEPQKSLPLSMNAAVV---S 1134

  Fly  1275 HEDR-QFVIEAQPAKRI--------------KTSDLVVASSSQQPTSFNFSFNN---QNSSNSVP 1321
            ||:: ...|:..|.:.|              .|...|:.:.::....:|.....   ....:..|
 Frog  1135 HEEKIACTIQNSPTRSIDIPRPDVYDSNRCVSTEKTVLVTQARLVRQYNIQVPEILVTEEPDKDP 1199

  Fly  1322 ELQSSKEERLRRFT----SSGGSMIPISECPDLDNSPKMIRTPLLSGGSFQD-----VSVKVNNE 1377
            |:|::::|...:|:    |...|.:|..:.|.   ..|.||...|...|.:.     :|..::.|
 Frog  1200 EVQTNEQETQEKFSWPQRSGSLSNLPTEKLPP---KKKRIRLADLEHSSAESSFDSTISRSLSRE 1261

  Fly  1378 ---------TGSSSKERKLMALVSGSGLL---GVSSGPQHFQFPPINSITAFNPLTLP---PMSG 1427
                     :.|..||..|    ...|..   ||:...:....|     |:.|...:|   ..|.
 Frog  1262 SSLSRASSFSASFDKEEPL----KSDGFAKTDGVTKSSEFLTIP-----TSLNTFGVPREMRRSA 1317

  Fly  1428 GDKTTPVTPIPHV----------PGMPGPGSLTP----------------QMPLLP----PPPQQ 1462
            .::.:...|...|          ..|....|::|                .:|||.    |..:|
 Frog  1318 SEQISCTQPSMEVIEYRSKSFDCGTMSRSRSMSPTNSVTSKFQSIILSSGHVPLLERRRGPLVKQ 1382

  Fly  1463 LQLPI----PSSRGRSPN-RKQPSPLLLGGGSGELKALSPFGGVQNVPSEFSRQPP--------- 1513
            :.|.|    |.|..:|.| ..||...:|    .::.|..|     :..|:.|..||
 Frog  1383 ISLSIGQESPVSIVKSKNLNHQPEKGIL----SQMHATEP-----SPNSKLSCAPPIQHSLCSSS 1438

  Fly  1514 --------------------TPAQRQALQWNSKEAPKK---APFNFLRM--ADNVKTTEPEVR-- 1551
                                |..:.:.....|||...|   ||...|::  :...|.:.|.:|
 Frog  1439 LSSSHKSLLNEDFISGIRNSTAGEEKEKNMLSKETESKTFYAPKYQLKIQKSQESKISTPNIRTA 1503

  Fly  1552 -------HFN------------LENVISGKQQELP--------------LTPLH----------- 1572
                   |.:            :.|:.:.:|.|..              :.|:|
 Frog  1504 TEIIHEVHSSVSWSTISDIKGVVSNICTSQQSENTSAKSYGKFLNTKPVVVPVHNYSNSLYCGYS 1568

  Fly  1573 ----------------------VDTPNG-------NAPEETS----------------------- 1585
                                  |..||.       ..|:|:|
 Frog  1569 DLLPEILVTQDHGHRITSEANSVPVPNSKDCIIMPKCPDESSGPLRVAHNTYTYENSVQESARSA 1633

  Fly  1586 -PVAS------ASASAKSKFLRP----------------------------TSLPLKPGTFTPKR 1615
             ||:|      .|||:| :.|.|                            |:|.:|.|.|..:|
 Frog  1634 MPVSSLLTQQETSASSK-RMLSPANSLDIAMEKHQKRVKDESGAAFNSSNQTNLTMKIGEFVKQR 1697

  Fly  1616 HHGI------TPTANTL---PLISPETPRPSKSCVQLYLN------------------------- 1646
            ...:      |....:|   |..:|:..|...||:.:.||
 Frog  1698 KPVLVRQLCTTDPGESLDQEPTHAPDNNRKLNSCLDIQLNVLNSARKSIYIFDKSDEVVEPEKNK 1762

  Fly  1647 -------------------------------------------------------------GHAY 1650
                                                                         .|..
 Frog  1763 LLESSCSAVSLPENCTVNTQAGALNSVYTCQERRSPLATKTVHIQGQVKLGAAISVVNAGDMHRL 1827

  Fly  1651 TYLGLKCSTKMFYC------TVNCPQPSYVAGMHKLSMYSVWQVCEENQPHPLGFKLKQVMALYD 1709
            ::..||.||...:|      .::.||..     .|:|.|:.|.: ..|.|:|:|...|..::|.:
 Frog  1828 SFPSLKTSTSFTWCYLLKRKPIHLPQND-----QKISAYASWSI-SFNNPNPMGLPTKVALSLLN 1886

  Fly  1710 SRQRMLGNGSSTAMAGSGKLSYNLVASQQ------IVSSPSTSSTSSAFYQGPLKTPPTVTIAAL 1768
            |:|:            |.|.::..|.:..      :.||...:||....:   .||       :.
 Frog  1887 SKQK------------SEKFTFTFVKTSHPKQDILVYSSKWKNSTRKLSH---YKT-------SE 1929

  Fly  1769 SEANVAAKANEEAQAKKLETSPSGQP-----LVGGYESHEDYTYIRGRGRGRYVCSECGIRCKKP 1828
            |:||....::...:..|...|...:|     ..|||:|:|:|.||||||||:|:|.|||||||||
 Frog  1930 SQANHLKSSDPSTEQDKESFSNKNEPRRVKIFDGGYKSNEEYVYIRGRGRGKYICEECGIRCKKP 1994

  Fly  1829 SMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINPGPMPPDSEFLDVDM 1893
            |||||||||||||||:.|::|||||||||||||||:||.|.|||:::|:..||:.      |.|.
 Frog  1995 SMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCLDMGVAVGPVD------DQDT 2053

  Fly  1894 DFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARGLLSLSMTPPIPQSV 1958
            |...:.....|.||...|.:||..|..||:.|..|:          :|..|   ||.||.:..|.
 Frog  2054 DDSGERQRYTGERTGFDADDSDGGDDDDNDDEDEDS----------QAESG---LSATPSVTASP 2105

  Fly  1959 SPYPQL----------QDTPLP-AASPANSIGSSGSQPKRLVCSFTSPKP-----PFDYQKQEQY 2007
            ..||..          :|..:| ..|.:||:   .|.||.|:...|:...     |..::::
 Frog  2106 QHYPFRNSQQDASNVDEDLRVPHCFSQSNSM---DSLPKALITRMTAMTTSTICRPESHEER--- 2164

  Fly  2008 YSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSVPAHDLPKSQAQQMHDVIFGTSGNES 2072
             |..:.|:....:|:|.|:|..|.           ..:||   |.|::..:.:     ||:.:..
 Frog  2165 -SKVDFSQVTTGLASEASSPKSLC-----------HQMSV---DYPEADTESL-----GTTKSMR 2209

  Fly  2073 GF----------------MKTLISVSDKV--RISAEMEEQAKHEAEGEDVQLQTYIKEH-ALHQA 2118
            |.                .:|:.|.:|.:  :::......:..:|...|.. .|::..| .||..
 Frog  2210 GHSESSSATTPSSPVDRSTQTMDSSTDAIDLKVNQHKSTASAQQASSMDPP-HTHLFSHLPLHSQ 2273

  Fly  2119 KIKQSQFSRSYLINTLYTAASPVMSSSSTLFTANSRPVMSVNEVPSIEV-HEVKT---PEAIESP 2179
            :..:|.:|...:.......|.  :::.||.....:.||...  :|::.| |...|   .:|.|.|
 Frog  2274 QPARSPYSMIPVGGIQLVPAG--LAAYSTFVPLQAAPVQLT--IPAMGVIHRTSTTVGDKAAEVP 2334

  Fly  2180 RSAPEQAPVILAQIAQEENEEPNIAEPHNANLPAAVQQP--DVN-EFTGVLG------NPTAPPT 2235
            .:   |.|:.:|::.......| |.:.:.:.|.....||  .:| |...:||      .|...|:
 Frog  2335 NT---QNPIGVAEVNGVVPCIP-IGQVNMSGLSTPGLQPLQPLNVETLSILGLSNTNVAPQIHPS 2395

  Fly  2236 S-SVTATSVSTTTAAPVAPSSTANSTQ---------------PAQRTVIVGEDGF---------- 2274
            . ::.|..:...||:|...||.:..|.               |:...:.|...|.
 Frog  2396 GLTLNAVGLQVLTASPGTQSSPSPQTHIPGLQILNIALPTLIPSISPITVESQGVSDQSSSCSTA 2460

  Fly  2275 -----------------KSSTPTSKSG--DLQHVSYGRGVPP-----APIAGDARPTCTMCSKTF 2315
                             :|.:|...||  :...:|:...|..     ..:..|..|...:||.:.
 Frog  2461 IGKGSATFTVADTKNMKQSESPKGSSGVQECHKISHELSVTEEKPSVCSLTADKGPKLKLCSNSS 2525

  Fly  2316 QRQHQLTLHMNIHYMERKFKCEPCSISFRTQGH---LQKHER 2354
            ..|.:::...:::.   |..|:  |.|.....|   |.:|:|
 Frog  2526 SSQTKISSSADLYI---KANCD--SASKPPNSHTLSLLRHQR 2562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368	14/19 (74%)
		zf-H2C2_2	499..523	CDD:463886	17/23 (74%)
		C2H2 Zn finger	514..536	CDD:275368	15/21 (71%)
		PRK12323	<1185..>1269	CDD:481241	16/110 (15%)
		zf-C2H2	1816..1838	CDD:395048	19/21 (90%)
		C2H2 Zn finger	1818..1838	CDD:275370	18/19 (95%)
		zf-H2C2_2	1830..1855	CDD:463886	20/24 (83%)
		zf-C2H2	1844..1868	CDD:395048	18/23 (78%)
		C2H2 Zn finger	1846..1868	CDD:275370	18/21 (86%)
		zf-C2H2_8	<2305..2352	CDD:464935	10/49 (20%)
		C2H2 Zn finger	2308..2328	CDD:275368	3/19 (16%)
		zf-C2H2_jaz	2333..2359	CDD:432381	8/25 (32%)
		C2H2 Zn finger	2336..2358	CDD:275368	7/22 (32%)
		C2H2 Zn finger	2381..2403	CDD:275368
hivep1	XP_002932729.3	C2H2 Zn finger	374..394	CDD:275368	14/19 (74%)
		zf-H2C2_2	387..411	CDD:463886	17/23 (74%)
		C2H2 Zn finger	402..422	CDD:275368	14/19 (74%)
		zf-C2H2	1982..2004	CDD:395048	19/21 (90%)
		C2H2 Zn finger	1984..2004	CDD:275370	18/19 (95%)
		zf-H2C2_2	1996..2021	CDD:463886	20/24 (83%)
		C2H2 Zn finger	2012..2030	CDD:275370	15/17 (88%)