Protein Alignment shn and hivep3

DIOPT Version :10

• Sequence 1: NP_001260883.1
• Gene: shn / 36171
• FlyBaseID: FBgn0003396
• Length: 2587
• Species: Drosophila melanogaster
• Sequence 2: XP_012812809.1
• Gene: hivep3 / 100489803
• XenbaseID: XB-GENE-482557
• Length: 2140
• Species: Xenopus tropicalis
• Alignment Length: 2483
• Identity: 530/2483 - (21%)
• Similarity: 809/2483 - (32%)
• Gaps: 951/2483 - (38%)

  Fly   379 PPPSVAIHEFSANFVNSNHVNAIGHEESIISNSGYKAAGR---TRTPLANSNSNTNSTS------ 434
            ||..|.:.:   :|.:|..:...|....:         ||   .:.||:...|.:.:||
 Frog    40 PPGEVVVQQ---SFPSSLKIPREGPPRRV---------GRPCKPKGPLSEQLSKSQTTSPAFMAP 92

  Fly   435 NSNSNHAANATL---------SPAS--FAQHQQLTQPT---------------TVSPGIPGGAAA 473
            .:..:|:...:.         .|:|  .|.|.::|.||               :|..|.......
 Frog    93 RAAPDHSLEGSTWQVVDPIHPGPSSSYSALHARITCPTEDPSQKTYLHRPTEVSVKQGEEPHKKE 157

  Fly   474 PNPACEKSGRYVCQYCNLICAKPSVLEKHIRAHTNERPYPCDTCGIAFKTKSNLYKHCRSRSHAA 538
            ..|  :|.|:|:||||:..|||||||:||||:||.||||||..||.:||||||||||.:|.:|..
 Frog   158 KKP--QKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHAHRI 220

  Fly   539 RARGLEVPADADDGLSDQDAELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLP 603
            :| ||         .|:...|:.....|:....|    |.|:.||...||.|..:::.:
 Frog   221 KA-GL---------ASETGGEMYPPCLEMEQLGG----EEIDYPTEGESTDSEEETSTM------ 265

  Fly   604 TYMQQLPLGSPAAGTLPPTTADNHHSATAQHRQSIDYKPYKPKFHNASLYSCSSKELQQQQQQLQ 668
                                                               .|..||..:|:|.
 Frog   266 ---------------------------------------------------LSLTELSPRQKQC- 278

  Fly   669 IQQQQQQHQLAQQKLSIQLPLVQQPSLA----------HPTLSPSTQMKMKHHINSHQIQLQLQQ 723
                .....:.|:.||.:|..|..||::          .|::.|..:.:..|.| ..::.|:|.:
 Frog   279 ----HSSFIVGQKVLSHELTSVPHPSVSIKPEEFTQFGDPSMDPLHKSEDTHTI-KQKLALRLSE 338

  Fly   724 QQSLLAQQSLLAAMPPGGVYYLGQPSYYNQDTAAAIHQHALAIQQFQIHLAQQQQQQQQQHPPLV 788
            ::....:|..|:....|..    :..|:::..:|                      :||..||..
 Frog   339 RKKASEEQMFLSPGSKGST----ESGYFSRSESA----------------------EQQLSPPNT 377

  Fly   789 KA---------------------TPPMQQ-----PPSLPPQQLVRANSQISSVATAPATPTPAAN 827
            .|                     ||.:||     .||:.|             .:.|.|
 Frog   378 NAKSYAEIILGKCGRIGQRSTMTTPALQQGPTEEKPSIGP-------------ISVPRT------ 423

  Fly   828 LSTFASSSGGKQVNVAKVQEHISKLISQNEAIVENKEILLQKKYPKQLSRSRSFNNANSNNASQH 892
                            :|.|||:|||:.|||:|:..||...|.....|||..|..
 Frog   424 ----------------QVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSIE---------- 462

  Fly   893 GSNASALHANNSQNNTNAQMPERETKVNLAQAIFQKQQHQ-LQQQQQQQITQQQQQQLEQQNYYT 956
             |..:||:.:..|.:... :||:           .|.:|. |..:|....|:
 Frog   463 -SPKAALYRDPFQFDPKC-LPEK-----------TKGEHSFLSLKQSHSATE------------- 501

  Fly   957 YIQQQQECQQQQLEPPNGVVKRNAYKPGVVMTTPVKQQQQLPPP----PSPLPMQTMQYRQDPAT 1017
                                           |.|:.:...:|..    .||...:......|
 Frog   502 -------------------------------TVPLLRSHSMPSSACTISSPHTFRASYSFDD--- 532

  Fly  1018 PVTKIEQPTTAVPVMPLNLSAKPKPTLVTVPVSSLSTSSLAPTPTTSTNPTSSSKTAPPPAQVNN 1082
               :|.:|  ||.......|:.|: .|...|...|      |.....|:...||.....|.:.::
 Frog   533 ---RIVEP--AVSSQSHVFSSHPR-LLKRQPAIEL------PLGMEYTSEECSSVIKDTPCKPSD 585

  Fly  1083 SI-IKNLLLNARGLAVPIGEGDDAVYSCPICASEFRSADDLKLHNSTYCQD-------------- 1132
            .: :|...|:.:...|...:|   :|.|.||.:.::...:.:.|...||.:
 Frog   586 ELEVKESELSKKSGKVGRAKG---LYECNICGARYKKRGNYETHKKYYCSELQTLKPQIAGDQGS 647

  Fly  1133 ------------------------------------------------------ASSSAPMSPAS 1143
                                                                  |:|.||.||.:
 Frog   648 VETRKGFTEHEKWPHMLHYKVSPGLEQSTIRKRRIVKSPGDDEESQSFDMPESQATSVAPGSPFT 712

  Fly  1144 SPFR---------------SNSISLS-----LPELKS--------------HMANSKNPLSLAKL 1174
            ...|               |.|:|:|     :|.|:|              |.::.:...|:.:|
 Frog   713 LSDRALNIHRDAGKTATDYSESVSVSDVQCRMPALESKEKAVLSKEISVIQHTSSFERSESMEQL 777

  Fly  1175 AWSQLKTKRSSLVLSRLSAAQTP-------ARTSTVTAPTVTASAPAPAVATVTAPSSAPAPQIE 1232
            :....:.|.::|. |..||..||       .|...:..|.:..:.......|...|  .|..|.:
 Frog   778 SSFDEEDKPAALA-SLCSARHTPHSLQPRLVRQHNIQVPEILVTEEPDKSETDLEP--PPKEQGK 839

  Fly  1233 ALRFVDAPLPSPGPLLGKTPLVDYAQQSTPRKAQ---------------DSVVITK--------- 1273
            |..|   ..|.....|.:.|    |::..|:|.:               :|:.:|:
 Frog   840 AEEF---QWPQRSQTLSQLP----AEKLPPKKKRLRLAEMTQSSGESSFESMSLTRSPSQESSVS 897

  Fly  1274 --------MHEDRQFVIEAQ------PAKRIKTSDLVVAS------------SSQQPT------- 1305
                    ...:..|..|.|      |:|......|.|.|            |.|.|.
 Frog   898 HASSRSVSFEREEGFKAEMQCQTSESPSKSQGHHMLTVPSHHHHAREMRRSASEQTPNVSQTPQI 962

  Fly  1306 ----SFNFSFNNQNS--SNSVPELQSSKEERLRRFTSSGGSMIP-ISECPDLDNSPKMIR----- 1358
                |.:|.:.|..|  |.|.|..|    ||.:.|:....|:.. ::..||:     |:|
 Frog   963 SENRSKSFDYGNLTSPASTSSPTAQ----ERRKCFSIRQTSLSKHVAHEPDM-----MLRDWSET 1018

  Fly  1359 ------TPLLSGGSFQDVSVKVNNETGSSSKERKLMALVSGSGLLGVSSGPQHFQFP-PINSITA 1416
                  :.:::...|...||       :|.|::|             |..||..|.| .:...|.
 Frog  1019 EQPSSSSHIIAKSVFYQSSV-------TSQKDQK-------------SDSPQPKQTPKAVQPNTE 1063

  Fly  1417 F--------------NPLTLPPMSGGDKTTPVTPIPHVPGMP-GPGSLTPQMPLLPP----PPQQ 1462
            .              :||.||..|  .:..|..|:..:...| ...|:||.:...||    .|..
 Frog  1064 LQEKACLSHQLPVLPHPLILPKQS--SELFPSQPLSDILSAPFSLPSVTPSVFHRPPIALLHPDH 1126

  Fly  1463 LQ----------------------LPIPSSRGRSPNRKQP--------SPLLLGGGSGELKA-LS 1496
            ||                      ||.|.|...||....|        :|..:.|...:||: :.
 Frog  1127 LQIPHHLNEQTMGTSFRQLPPYVHLPYPGSSPFSPTLFIPVQPQFALSTPTEIEGHYSQLKSVIP 1191

  Fly  1497 PFGGVQNVPSE---FSRQPPTPAQRQALQWNSKE-------------APKKAPFNFLRMADNVKT 1545
            |..||.:|...   ||.....|:........|.:             .|.:...:...:...:.|
 Frog  1192 PPIGVSSVSPHKDYFSEALHCPSHSPLTSEPSSQGVTVHSDPVVSLVVPVRLQTHMPSIGSAMYT 1256

  Fly  1546 TEPE--VRHFN----------LENVISGKQQE--LPLTPLHVD----TPNGNAP---EETS---P 1586
            |..:  |.|.:          |||...|....  ..:.|:|.|    ||....|   .||:   |
 Frog  1257 TLSQILVTHSHCSPSALVIQRLENQSEGSHGSNLAHILPVHQDNLLQTPYLRVPFTKVETTHYMP 1321

  Fly  1587 VASASASA------------KSKFLRPT-SLPLKPGTFTPKR----------------------- 1615
            :||:|.||            ..:.|.|. ||.|...|...||
 Frog  1322 LASSSESALGSDLSSASVGGSKRMLSPAGSLELTMETQQQKRVKEENVPEEGGHCEMLKAQDEGR 1386

  Fly  1616 ------------------------HHGITPTANTLPLISPETPRPSK------------SC---- 1640
                                    |...:|.|::..| ||....||.            ||
 Frog  1387 TVSTDTVVSLAKGRLEQLPSCQAIHEDSSPKASSKSL-SPTLAGPSHTKSPEEYKEQIYSCKITV 1450

  Fly  1641 -----------------------VQLYLNG--------HAYTYLGLKCSTKMFYCTVNCPQPSYV 1674
                                   |.||:.|        ...|:..|..:|.:.:|.:|..:|::.
 Frog  1451 KTEHPEELVEPLSTYTSLSTRVPVNLYVPGGSEVTETKKVQTFPTLHTTTNVSWCYLNYVKPNHA 1515

  Fly  1675 AGM-HKLSMYSVWQVCEENQPHPLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQ 1738
            ... .:.|:|..|.:...| |:..|...:..::|..|:|:                     .|.:
 Frog  1516 QQTDRRASVYGSWCISLYN-PNLPGISTRAALSLLRSKQK---------------------TSTE 1558

  Fly  1739 IVSSPSTSSTSSAFYQGPLKTPPTVTIAALSEANVAAKANEEAQAKKLETSPSGQP--------- 1794
            |.::..|:.:.:     .|..|..|....::||::..:..:|....:.|....|:|
 Frog  1559 IYTTADTTHSDT-----DLVVPSRVRKPKMTEAHLPPRVQKEVPNAEKEEDKRGKPEDTGPTVRR 1618

  Fly  1795 --------LVGGYESHEDYTYIRGRGRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNF 1851
                    ..|||:|:|:|.|:||||||:|||.|||||||||||||||||||||:||:.|.||||
 Frog  1619 SEPARIRIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDLRPYVCKHCNF 1683

  Fly  1852 SFKTKGNLTKHMQSKTHFKKCIELGINPGPMPPDSEFLDVD---MDFDQQSSTSAGGRTSSMAGE 1913
            :|||||||||||:||.|.|||.|||:    :||....||.:   .|...|.|........|...:
 Frog  1684 AFKTKGNLTKHMKSKAHSKKCQELGL----LPPSQAELDAEEGTSDERWQDSDLLEEHQFSDFED 1744

  Fly  1914 SDSDDYSDNESESSDTDESKSRQKEH----------EAARGLLSLSMTPPIPQSVSPYPQLQ--- 1965
            ||.|:.||.|.:..: ||.:|::::|          |..:...:...:|....|.:|:|.::
 Frog  1745 SDDDEDSDEEDDEEE-DEEESQEEKHPSPTVRDSPNEPTQDPETAGSSPAYQFSPNPFPTVEAPE 1808

  Fly  1966 ------DTPLPAA---------SPANSI-GSSGSQPKR---LVCSFTSPK--------PPFDYQK 2003
                  ...|||:         ||...: |.|...|.|   |....||||        .|.....
 Frog  1809 KDNRARSFDLPASRDTLSCRRWSPGKEVSGCSRPGPSRRHLLQKRETSPKCFSTTGCPSPRRGMS 1873

  Fly  2004 QEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISPSPVSVP--AHDLPKSQAQQMHDVIFG 2066
            ..|..::.:|..|.|.::....:|.....||   ..:||...:.|  .|..|..:.
 Frog  1874 PCQRLASAKEVSPLRCISPRHLSPHRDLSPR---TYMSPERGASPPVRHISPSREL--------- 1926

  Fly  2067 TSGNESGFMKTLISVSDKVRISAEMEEQAKHEAEGEDVQ------LQTYIK-------------- 2111
                 :|...|.:...        :....::.:.|.|.|      .||:||
 Frog  1927 -----TGLQCTTLRPG--------LASPPRYASPGRDEQQLSRSETQTHIKVQQGFFSSLALPHR 1978

  Fly  2112 --EHALHQAKIKQSQFSRSYLINTLYTAASP--VMSSSSTLFTANSRPVMSVNEVPSIEVHEVKT 2172
              |.|.::.|:..|.|  ..::..|.:..:|  :..|:..|||          .:|....|..:|
 Frog  1979 TSEAACNKQKLGPSNF--PVMLRPLCSQLTPHYLARSAENLFT----------HLPLHSQHLQRT 2031

  Fly  2173 P------EAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNANLPAA----VQQPDVNEFTGVL 2227
            |      ..|:..::.|...|.:|.|         :..||...:|.|.    ..|.:.:|.....
 Frog  2032 PYPMIPIGGIQMVQARPSPHPELLGQ---------SFFEPQPGDLEAVPFEQQHQEENDEQIRTS 2087

  Fly  2228 GNPTA-----PPTSSVTATSVSTTTAAPVAPSSTANSTQPAQRTVIVGEDGFKSSTP-----TSK 2282
            ....|     ||.|          ||..|:||||...|               :|||     :..
 Frog  2088 RKEEAKDRVIPPIS----------TAPTVSPSSTYCQT---------------ASTPPQPEMSQA 2127

  Fly  2283 SGDL---QHVSYG 2292
            ..||   :||..|
 Frog  2128 ETDLCHGEHVGEG 2140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368	15/19 (79%)
		zf-H2C2_2	499..523	CDD:463886	16/23 (70%)
		C2H2 Zn finger	514..536	CDD:275368	14/21 (67%)
		PRK12323	<1185..>1269	CDD:481241	20/105 (19%)
		zf-C2H2	1816..1838	CDD:395048	20/21 (95%)
		C2H2 Zn finger	1818..1838	CDD:275370	18/19 (95%)
		zf-H2C2_2	1830..1855	CDD:463886	19/24 (79%)
		zf-C2H2	1844..1868	CDD:395048	18/23 (78%)
		C2H2 Zn finger	1846..1868	CDD:275370	18/21 (86%)
		zf-C2H2_8	<2305..2352	CDD:464935
		C2H2 Zn finger	2308..2328	CDD:275368
		zf-C2H2_jaz	2333..2359	CDD:432381
		C2H2 Zn finger	2336..2358	CDD:275368
		C2H2 Zn finger	2381..2403	CDD:275368
hivep3	XP_012812809.1	C2H2 Zn finger	168..188	CDD:275368	15/19 (79%)
		zf-H2C2_2	181..205	CDD:463886	16/23 (70%)
		C2H2 Zn finger	196..216	CDD:275368	13/19 (68%)
		zf-C2H2	1648..1670	CDD:395048	20/21 (95%)
		C2H2 Zn finger	1650..1670	CDD:275370	18/19 (95%)
		zf-H2C2_2	1662..1687	CDD:463886	19/24 (79%)
		C2H2 Zn finger	1678..1696	CDD:275370	15/17 (88%)
		PHA03247	<1770..2137	CDD:223021	84/437 (19%)