DRSC/TRiP Functional Genomics Resources

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Protein Alignment shn and hivep1

DIOPT Version :9

Sequence 1:NP_001260883.1 Gene:shn / 36171 FlyBaseID:FBgn0003396 Length:2587 Species:Drosophila melanogaster
Sequence 2:XP_021323923.1 Gene:hivep1 / 100000517 ZFINID:ZDB-GENE-070912-512 Length:2636 Species:Danio rerio


Alignment Length:2911 Identity:614/2911 - (21%)
Similarity:954/2911 - (32%) Gaps:1073/2911 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 NSISENNYEFKSRDKASLSDSKMT---------LQQMAAVSSNQ------EPVAPNVANTMSNSS 272
            :.|.|...|||....|....::.|         |::...|:.||      .||........|.||
Zfish    16 DKIEEAQKEFKDPKGAHKDTNESTGRNSESIKGLKRKKVVAQNQLKKIPKSPVKKQSQTKKSISS 80

  Fly   273 IINSQQTTVNATPAT--------DEAPLG-DRSNISRYLHKKFKRLASTTEVDSWSATNGGGALQ 328
            .|:|::.|.::.|::        ::|..| :..:.||.:..:.:.: ||:|..:.| ..|..|..
Zfish    81 NISSKEATPSSFPSSPSHGSPKPEDAEDGPEEVSASRTVKVEQEEI-STSEPQALS-HKGAAAEP 143

  Fly   329 ASGDAVRTTSLSSNSSLSPPPTTPLANGHHLMTQQQSHQQVQQQQQQQQTPPPSVAIHEFSANFV 393
            ...:.|:|.|...:|.             :..||..||.....:...:...|..:       :|.
Zfish   144 CVAEPVQTESWCGDSC-------------NKSTQSPSHTSAPLEVLLKAMEPDFI-------DFT 188

  Fly   394 NSNHVNAIGHEESIISN----SGYKAAGRTRTPLANSNSNTNSTSNSNSNHAANATLSPASFAQH 454
            ...:.:.|||.....||    |.|..|    .|..|.|..:.::.....|.|.....|.||..||
Zfish   189 ERKNSSPIGHLGKSASNPVTYSDYAVA----MPAVNFNIQSQNSFMQPFNAAKQYYSSVASTGQH 249

  Fly   455 QQLTQP-----------------------TTVSPGIPGG-------------------AAAPN-- 475
              :|||                       |.:...:|.|                   |..||  
Zfish   250 --ITQPYMSGNRQQEKPGVQKSYSVGPSLTLMHAPVPSGSGGFPQSQPPVVQTCQSLSATVPNSI 312

  Fly   476 --PAC-----------------------------EKSGRYVCQYCNLICAKPSVLEKHIRAHTNE 509
              |..                             :|.|:|||:||...|||||||.||||:||.|
Zfish   313 QVPVTPGYNPVQMTTVVNFGASQVSDISAKDQKPKKQGKYVCEYCKRACAKPSVLLKHIRSHTGE 377

  Fly   510 RPYPCDTCGIAFKTKSNLYKHCRSRSHAARA----------------RGLEVPADADDGLSDQDA 558
            |||||.|||.:||||||||||.:|.:||.:.                :||...:|.|:. .|.|.
Zfish   378 RPYPCVTCGFSFKTKSNLYKHKKSHAHAIKLGLVKDSGSGSLSQESDKGLATHSDVDES-GDSDE 441

  Fly   559 ELSNSSSELPSRAGSPYEEPINSPTPSPSTLSAAKSAYIQQPPLPTYMQQLPLGSPAAGTLPPTT 623
            |.|.:..:..|               |.|:|:|...:.:|                :|..:..:.
Zfish   442 ESSAADLDADS---------------SQSSLTALSESSLQ----------------SASMIQGSQ 475

  Fly   624 ADNHHSATAQH-RQSIDYKPYKPK---------FH--NASLYSCSSKELQQQQQQLQIQQQQQQH 676
            |::.||...:: :.|...:..:||         .|  |.|.....|..:.....:....|:|:..
Zfish   476 AESEHSLVFENLKPSATQRGCEPKVTAALPKVVVHPVNVSPLRADSPRVTDSAPEQATAQRQRDF 540

  Fly   677 QLAQQKLSI----QLPLVQQPSLAHPTLSPSTQMKMKHHINSHQIQLQLQQQQSLLAQQSLLAAM 737
            |....:.::    .|..|...|....::|.......|..:.....|||.||......|..:...:
Zfish   541 QPTNLRSNVTVLSSLKEVDCTSPPQDSVSDDEDQHCKSPLGGSHAQLQRQQATDYSQQAQVKCLL 605

  Fly   738 PPGGVYYLG--QPSYYNQDTAAAIHQHALAIQQFQIHLAQQQQQQQQQHPPLVKATPP----MQQ 796
            .|..   ||  ...|:::..:|                    .|......|.||.|||    :.:
Zfish   606 SPRS---LGSTDSGYFSRSESA--------------------DQAMSPPSPFVKITPPGDTDITK 647

  Fly   797 PPSLPPQQLVRANSQISSVATAPATPTPAAN----LSTFASSSGGKQVNVAKVQEHISKLISQNE 857
            .|.:||..:|.|   :..|||......|:..    |.|.|.|          ::|.||||||.||
Zfish   648 TPHIPPCPVVAA---VMHVATIEKPRVPSGQMRPPLETKALS----------LEERISKLISDNE 699

  Fly   858 AIVENKEILLQKKYPKQLSRSRSFNNANSNNASQHGSNASALHANNSQNNTNAQMPERETKVNLA 922
            |:|::|:  |....|::.|.||            .||                            
Zfish   700 AVVDDKQ--LDSVKPRRTSLSR------------RGS---------------------------- 722

  Fly   923 QAIFQKQQHQLQQQQQQQITQQQQQQLEQQNYYTYIQQQQECQQQQLEPPNGVVKRNAYKPGVVM 987
                                      ::....|.:    ::..|..|:||   |:|::....:..
Zfish   723 --------------------------IDSPKSYIF----KDSFQFDLKPP---VRRSSSNSDIPK 754

  Fly   988 T--TPVKQQQQ--LPPPPSPLPMQTMQYRQDPATPVTKIEQPTTAVPVMPLNLSAKPKPTLVTVP 1048
            :  ||..:.:|  |...||       ||......|:|:    :.::|..|...:..|..|  |.|
Zfish   755 SPFTPTDKSKQVFLLSVPS-------QYPAMECLPITR----SNSMPTTPGQSALFPNVT--TQP 806

  Fly  1049 ------------VSSLSTSSLAPTPTTSTNPTSSSKTAPPPAQVNNSIIKNLLLNARGLAVPIGE 1101
                        :|||:....:..|:| .||....:|.     |....:::|..|...:.:.:..
Zfish   807 HQLRICQSFDDKISSLNDDVFSSAPST-PNPAVHPRTL-----VRQIAVEDLSTNDGHVLIQVHS 865

  Fly  1102 GDDA-------------------------------VYSCPICASEFRSADDLKLHNSTYC----- 1130
            .|::                               :|.|..|.:.:|..::.:.|...||     
Zfish   866 MDESHHGPSITHELRSKSFEHATERNRKPQQNKGTMYECETCRNRYRKLENFENHKKFYCSELHG 930

  Fly  1131 -----------------------------------------------------QDASSSAPMSPA 1142
                                                                 .|.|.:....|.
Zfish   931 PKNKPMHARETEHEVFGRGIQQPLLNRNAVITGNVEQPLMLRKRRKIKSVGDDDDQSPTETTPPC 995

  Fly  1143 SSPFRSNSISL-SLPELKSHMANSKNPLSLAKLAWSQLKTKRSSLVLSRLSAAQTPARTSTVTAP 1206
            |..|.|:..|. |:....||...|..  :.|.|...|:..:...|..||||    |.|.:.::.|
Zfish   996 SRSFDSSQSSTGSIGRTNSHHTQSLG--NSAILGQIQIIARAGELQESRLS----PIREAQISTP 1054

  Fly  1207 -------------------TVTASAPAPAVATVTAPSSAPAPQIEALRFVDAPLPSPGPLLGKTP 1252
                               |.:.|.|.....:.:...|:|...:|....:.....:...:.....
Zfish  1055 CKERGDLQRQGSGTSVIRHTNSLSRPNSFETSESIDRSSPVDPVEKETKISVKSHTETAVSSSQS 1119

  Fly  1253 LVDYAQQSTPRKAQDSVVITKMHEDRQFVI-----EAQPAKRIKTSDL----------------- 1295
            ..|  :.|||:      ..::.||.:.|.|     ..|.::.::.|::                 
Zfish  1120 YHD--RMSTPK------CPSQTHEKQSFAIVGDVPPVQQSRLVRQSNIQVPEILVTEEPDRDHET 1176

  Fly  1296 -VVASSSQQPTSFNFSFNNQNSSNSVPELQSSKEERLRRFT---SSGGSMI------------PI 1344
             ||.|:.:...:|::...:::.|....|....|::|:|...   |||.|..            .:
Zfish  1177 QVVESTEKPAETFSWPQRSESLSKLPTEKLPPKKKRIRLAQMEHSSGESSFESSLSRSLSRDSSL 1241

  Fly  1345 SECP------DLDNSPK------------------------------MIRTPLLSGGSFQDVSVK 1373
            |.|.      |.|:.|:                              ::|.......|:...||:
Zfish  1242 SRCSSISASFDRDDPPRSDSPSRADSVGKPPETQGVPVANNTLGVPGIMRRSTSEQISYTQSSVE 1306

  Fly  1374 V-------NNETGSSSKERKLMALVSGSGLLGVSSGPQHFQFPPINSITAF----NPLTL----- 1422
            :       :.:..|.|..|.|..:.:..        |:..|.||...:...    .||..     
Zfish  1307 ISCDYRSKSFDCSSMSPSRPLSPMQTAL--------PKTTQCPPSTLVPLIERRRGPLVRQMSLK 1363

  Fly  1423 ---PPMSGGDKTTPV-------------------------------------------------- 1434
               .|.....:|||:                                                  
Zfish  1364 IAPEPQIAVKQTTPIQRVPFTNECSGSQPRSVNLNTSALAQCFAVHSGEVSLPKNEQVVQSINLG 1428

  Fly  1435 --TPIPHVPGMPGP---------GSLTP-------QMPLLPPPPQQLQLPIPSSRGRSPNRKQPS 1481
              |..|.|.|:|.|         |.:.|       |..:.....::.::.||..:...|..|...
Zfish  1429 GKTEQPQVHGLPHPWHQTSRVVAGHVQPLVHMVGGQTDIKKSSDEKNKIFIPKYQMNCPVLKTGQ 1493

  Fly  1482 PLLLGGGSG--------------ELKALSPFGGVQNV------------------PSE-----FS 1509
            ...|.|..|              |:|......|:|||                  ||.     .|
Zfish  1494 TYSLAGVQGTQIPLPVITIPIANEIKGSHSNDGMQNVYVAQSSYQAVLNKPSIVQPSNAQVDTAS 1558

  Fly  1510 RQPPTPAQ-------------------------RQALQWNSKEAP----KKAPFNF-LRMADNVK 1544
            .:.|..|.                         ..::..:||..|    :|.|.:. ::|.:|:|
Zfish  1559 HKVPVSAPVPQILITHEHTLASASAVSKVSFPIAPSVNRDSKIGPEIQAQKQPGSVAVQMKNNMK 1623

  Fly  1545 TTE------------------PEVRHFNL---ENVISGKQQELPLTPLHV--DTPNGNAPEE--- 1583
            ||:                  .::...||   |:..|.|:...|...|.:  :.....|.:|   
Zfish  1624 TTDQIQNTEQSILSLGSLHCMQKLASANLCPQESTASSKRMLSPANSLDIAMEKTQKRAKDEHGA 1688

  Fly  1584 ---------------------------------TSPVASASASAKSKFLRPTSLPLKPGTFTP-- 1613
                                             |.||.|...:...:.| |.:|..:..|..|  
Zfish  1689 ACLTDGRSLNYLNSKMSEITRQRKLMLVRQVCTTEPVDSPIETDAPEQL-PETLDTEKNTQKPIP 1752

  Fly  1614 -------------KRHHGITPTANTLPLI---------------SPETPR--PSKSCV------- 1641
                         .|....||.|.:||.:               .||..|  ||||.:       
Zfish  1753 QVTTTEVSEQEMESRTPTTTPPARSLPGVQGYPMLENSTLKPQEKPEEQRWSPSKSPLRPPSFQG 1817

  Fly  1642 QLYL----------NGHAYTYLGLKCSTKMFYCTVNCPQPSYVAGM-HKLSMYSVWQVCEENQPH 1695
            |:.|          :.|..::..||.:|...:|.:...:|.:|..| .::|.||.| |...|.|:
Zfish  1818 QVKLASSVSVVNTRDSHRLSFPSLKTATTFTWCFLMKRKPLHVQQMDQRISAYSAW-VVNPNNPN 1881

  Fly  1696 PLGFKLKQVMALYDSRQRMLGNGSSTAMAGSGKLSYNLVASQQIVSSPSTSSTSSAFYQGPLK-T 1759
            |||...|.||:|:||:|.            |.|:.|....:..:.|...|       |.|.|| .
Zfish  1882 PLGLPTKVVMSLFDSKQT------------SKKIHYTQAKTTTLKSDILT-------YSGKLKDV 1927

  Fly  1760 PPTVTI---AALSEANVAAKANEEAQAKK---LETSPSGQPLV----GGYESHEDYTYIRGRGRG 1814
            .|.|.|   :..||.:...|.:.:...:|   .:||.|....|    |||:|:|:|.|:||||||
Zfish  1928 LPKVLIQQRSVPSENSGKTKPDTQPVNQKESDRDTSKSEPQRVKIFDGGYKSNEEYVYVRGRGRG 1992

  Fly  1815 RYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQSKTHFKKCIELGINP 1879
            :|:|.||||||||||||:||||||:|:|||.|:||||||||||||||||:||.|.|||:|:|:..
Zfish  1993 KYICEECGIRCKKPSMLRKHIRTHSDIRPFHCTHCNFSFKTKGNLTKHMKSKAHSKKCMEMGVAV 2057

  Fly  1880 GPMPPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQKEHEAARG 1944
            |.:             :.|.:..:|.|  ..||.:|..|...::|:..|.::::..:::.|.::.
Zfish  2058 GII-------------EDQDAEDSGDR--GRAGSADRQDSDGDDSDGPDDEDNEGEEEDEEDSQA 2107

  Fly  1945 LLSLSMTPPI---PQ--------------------SVSPYPQLQDTPLPAA-------------S 1973
            ...||.||.:   ||                    |.:|.|.||..|.|.:             |
Zfish  2108 ESGLSATPSVSASPQHFSANQADLAPSSLLAQMSISPNPSPALQSQPPPTSDSQTSDTESVAMTS 2172

  Fly  1974 PAN-----SIGSSGSQPKRLVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKP 2033
            |.:     ||.:|.|.|.....||||...|                      |:|..     |..
Zfish  2173 PVSLVRQMSISASCSSPGPNPTSFTSHPTP----------------------ASESH-----TSD 2210

  Fly  2034 RGSILLISP-SP-----VSVPAHDLPKSQAQQMHDVIFGTSGNESGFMKTLISVSDKVRISAEME 2092
            ..|:.::|| ||     :..|..|:|.|......    |....:.|...|:...:.:...:.:..
Zfish  2211 TDSVHMMSPVSPCRQMSIDYPDFDVPPSPPVSGK----GAKLGQDGVSSTISQPASECNANVDRG 2271

  Fly  2093 EQAKHEAEGEDVQLQTYIK-EHA--LHQAKIKQSQFSRSYL-INTLYTAASPV------------ 2141
            .|...:      .||..:. .||  ||:.:|..:....|:| :::.....||.            
Zfish  2272 TQTSSD------PLQGSLHFPHAGPLHEPRIGATTHLFSHLPLHSQQPPRSPYSMVPVGGIQLVP 2330

  Fly  2142 --MSSSSTLFTANSRPVMSVNEVPSIEVHEVKTPEAIESPRSAPE-----QAPVILAQIAQEENE 2199
              :::.||.....:.||...  :|::.|...:|...:.:|.::|.     ..|::          
Zfish  2331 AGLAAYSTFVPIQAGPVQLT--IPALSVIHRQTGSPLSAPNTSPRPDCSPTQPLV---------- 2383

  Fly  2200 EPNIAEPHNANLP-------AAVQ---------QPDVNEFTGVLG--NPT--APPTS-SVTAT-S 2242
               :.||.::.||       |.:|         ||...|...|:|  |.|  .|..| .:.|| .
Zfish  2384 ---VQEPVSSVLPCFPLGQVAGLQTLGAHQTALQPVGLETLSVVGLANSTQLVPQQSLPLNATLG 2445

  Fly  2243 VSTTTAAPVAPSSTANSTQ-----------PAQRTVIVGEDGFKSSTPTSKSGDLQHVSYG---- 2292
            |....|:|....|||:..|           ||   :|.......:.:|...:.|......|    
Zfish  2446 VQVLAASPAPQCSTASPAQIPGLQILNIALPA---LIPSLSPLSALSPLPATQDKPRSPEGVASV 2507

  Fly  2293 ------RGVPPAPI---------AGDARPTCTMCSKTFQRQHQLTLHMNIHYMERKFKCEPCSIS 2342
                  .|.||||:         .|||......|.:.                 ||......|:.
Zfish  2508 TLPAQVAGSPPAPLPSASPPTANPGDAAVNAKPCMEV-----------------RKVSQNNPSVG 2555

  Fly  2343 FRTQGHLQKH----ERSEAHKNKVMMTSTFGVPTTSNPRPFECTDCKIAFR 2389
            .|..|..:|.    |:|:|........|    |:.||.|     .|.:|.:
Zfish  2556 SRDTGGAEKTTGMVEKSKAPPQPPSPCS----PSLSNER-----GCNVAHK 2597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shnNP_001260883.1 C2H2 Zn finger 486..506 CDD:275368 14/19 (74%)
zf-H2C2_2 499..523 CDD:290200 17/23 (74%)
C2H2 Zn finger 514..536 CDD:275368 15/21 (71%)
zf-C2H2 1816..1838 CDD:278523 18/21 (86%)
C2H2 Zn finger 1818..1838 CDD:275370 17/19 (89%)
zf-H2C2_2 1830..1855 CDD:290200 19/24 (79%)
zf-C2H2 1844..1868 CDD:278523 20/23 (87%)
C2H2 Zn finger 1846..1868 CDD:275370 19/21 (90%)
zf-C2H2 2307..2328 CDD:278523 1/20 (5%)
C2H2 Zn finger 2308..2328 CDD:275368 1/19 (5%)
zf-C2H2_jaz 2333..2359 CDD:288983 8/29 (28%)
C2H2 Zn finger 2336..2358 CDD:275368 6/25 (24%)
C2H2 Zn finger 2381..2403 CDD:275368 2/9 (22%)
hivep1XP_021323923.1 C2H2 Zn finger 354..374 CDD:275368 14/19 (74%)
zf-H2C2_2 367..391 CDD:316026 17/23 (74%)
C2H2 Zn finger 382..402 CDD:275368 14/19 (74%)
zf-C2H2 1994..2016 CDD:306579 18/21 (86%)
C2H2 Zn finger 1996..2016 CDD:275370 17/19 (89%)
zf-H2C2_2 2008..2033 CDD:316026 19/24 (79%)
zf-H2C2_5 2022..2048 CDD:316431 21/25 (84%)
C2H2 Zn finger 2024..2042 CDD:275370 16/17 (94%)
Herpes_BLLF1 <2112..2412 CDD:330317 67/351 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 108 1.000 Domainoid score I6359
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 347 1.000 Inparanoid score I2275
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm25148
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45944
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
55.150

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