DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZBTB47

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_660149.2	Gene:	ZBTB47 / 92999	HGNCID:	26955	Length:	747	Species:	Homo sapiens

Alignment Length:	604	Identity:	127/604 - (21%)
Similarity:	196/604 - (32%)	Gaps:	194/604 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DITPLAETNGEQRQNPQESAQNQEQPQPRQDLAGKSVGSADDGVSGTVGQIMDYL-EDDAGATAD 67
            ||...|:|.|    .|:..|  :|.|.|.........|:|...|..|:|....:. |:..|...:
Human   141 DIKQEADTPG----LPKIYA--REGPDPYSVRVEDGAGTAGGTVPATIGPAQPFFKEEKEGGVEE 199

  Fly    68 QDAEMGEAEYLDGEMPQEDESETPQTEKANEGCQ----ESSNKKDLQESAAKDDFSKEKSGEDGE 128
            ..........|:|....|:|.....|....|..|    .:.|.:.|..|          :|.:|:
Human   200 AGGPPASLCKLEGGEELEEELGGSGTYSRREQSQIIVEVNLNNQTLHVS----------TGPEGK 254

  Fly   129 KDTDKEKKATHL-HED----NNDDAEKDGDEADAEDEDDV------EKPEDEDGTEEGDEAIEED 182
            ...........| .||    ::|:.|:|.:|.:.|:|::.      |:.|:|:|..:|:|. ||:
Human   255 PGAGPSPATVVLGREDGLQRHSDEEEEDDEEEEEEEEEEEGGGSGREEEEEEEGGSQGEEE-EEE 318

  Fly   183 EDALDEDEDPNEEVEE---IEPDFETGTDAEGELITGDEPGDLADVPIRERKKEEPVDEDQCRVC 244
            ||...|.|:..||.||   .|.|.|:..:.|||  .|:..|.......|..:.:.|
Human   319 EDGHSEQEEEEEEEEEEGPSEQDQESSEEEEGE--EGEAGGKQGPRGSRSSRADPP--------- 372

  Fly   245 TSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMPQFICTKCMGSLTIAIQLRKQLETTDQE 309
                                            |...|
Human   373 --------------------------------PHSHM---------------------------- 377

  Fly   310 LRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKK 374
                .:||:...|| ||                               :.:.:.|.....::.|.
Human   378 ----ATRSRENARR-RG-------------------------------TPEPEEAGRRGGKRPKP 406

  Fly   375 KPG-----PRGRPRKKPLKRGTDSDGEPSSAQKKKYQPSSTASVGPFECP-----------NCDL 423
            .||     .||.|       .||..|.....::|::.|..       :||           :.::
Human   407 PPGVASASARGPP-------ATDGLGAKVKLEEKQHHPCQ-------KCPRVFNNRWYLEKHMNV 457

  Fly   424 TFSRKQ-------------SYVLHRKTHERIEHACPICGKKFKVEWAYKTHMQ-RHEQERAHFRC 474
            |.||.|             ..:|||:|.......|..|||.||..|:...|.: .|......|.|
Human   458 THSRMQICDQCGKRFLLESELLLHRQTDCERNIQCVTCGKAFKKLWSLHEHNKIVHGYAEKKFSC 522

  Fly   475 ELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAVGCQRHKEDSVRIK--E 537
            |:|.|.|...|.::.||.....:..|  .|:.|.::|.....|:.|   ..|...|...|.:  .
Human   523 EICEKKFYTMAHVRKHMVAHTKDMPF--TCETCGKSFKRSMSLKVH---SLQHSGEKPFRCENCN 582

  Fly   538 EQSRFKQESRSKDDRHHGN 556
            |:.::|.:.||....|.|:
Human   583 ERFQYKYQLRSHMSIHIGH 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	2/72 (3%)
		zf-C2H2	416..438	CDD:278523	9/45 (20%)
		C2H2 Zn finger	418..438	CDD:275368	9/43 (21%)
		zf-C2H2	443..465	CDD:278523	8/22 (36%)
		C2H2 Zn finger	445..465	CDD:275368	8/20 (40%)
		C2H2 Zn finger	474..491	CDD:275368	6/16 (38%)
		C2H2 Zn finger	504..521	CDD:275368	4/16 (25%)
ZBTB47	NP_660149.2	BTB	4..110	CDD:279045
		BTB	18..113	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..424		56/305 (18%)
		C2H2 Zn finger	438..459	CDD:275368	2/27 (7%)
		C2H2 Zn finger	465..484	CDD:275368	3/18 (17%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		COG5048	520..>601	CDD:227381	23/85 (27%)
		C2H2 Zn finger	522..542	CDD:275368	8/19 (42%)
		zf-H2C2_2	534..559	CDD:290200	6/26 (23%)
		C2H2 Zn finger	550..570	CDD:275368	5/22 (23%)
		zf-H2C2_2	562..585	CDD:290200	6/25 (24%)
		cxxc_20_cxxc	577..>621	CDD:274982	7/25 (28%)
		C2H2 Zn finger	578..598	CDD:275368	4/19 (21%)
		C2H2 Zn finger	606..626	CDD:275368
		zf-H2C2_2	618..643	CDD:290200
		COG5048	630..>701	CDD:227381
		C2H2 Zn finger	634..654	CDD:275368
		zf-H2C2_2	646..669	CDD:290200
		C2H2 Zn finger	662..678	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..747
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000