DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12391 and ZNF518B

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001362745.1	Gene:	ZNF518B / 85460	HGNCID:	29365	Length:	1074	Species:	Homo sapiens

Alignment Length:	265	Identity:	55/265 - (20%)
Similarity:	92/265 - (34%)	Gaps:	80/265 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 KKPGPRGRPR------KKPLKRGTDSD---------GEPSSAQKKKYQ--PSSTASVGPFECPNC 421
            |:|...|.||      :..|.:|::::         .:..|..|...|  ...|...|.:.|..|
Human    25 KQPDANGAPRPNRQEAQTLLYQGSEAEAAMMTIATCAKCKSVHKISLQDLQKGTGKDGMYVCFQC 89

  Fly   422 DL-------TFSRKQSYVLHRKTHERIEHACPICGKKFKVE-------------------WAYKT 460
            .|       .|....|...|  ...:.|:.......||||.                   ..||.
Human    90 SLGAAPPNFHFVSNNSSATH--VGNKTENFSSSVNSKFKVRNFKPGKYYCDKCRFSTKDPLQYKK 152

  Fly   461 HMQRHEQERAHFRCELCPKIFRLRAELKHHMAQRHDEHG--FIYECKRC-----QRTFLTQQRLQ 518
            |..:||:.:  |.|..|..|...:.|.:.|:.    :|.  |.|:|:.|     :..::.:...:
Human   153 HTLQHEEIK--FICSHCSYISYTKGEFQRHLV----KHTGIFPYQCEYCDYGAIRNDYIVKHTKR 211

  Fly   519 RHQAVGCQRHKEDSVRIKEEQSRFKQESRSKDDRHHGNNSSKRRPGEGRDLFKAVAPPTT--TYW 581
            .|:..|.:|..:...:::.:::                .:||:.|    :|.||..|.||  ..|
Human   212 VHERAGAKRPVKAVAKLEPKRT----------------GTSKQNP----ELLKASNPRTTFQNKW 256

  Fly   582 SDSFS 586
            ||..|
Human   257 SDQLS 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071
		zf-C2H2	416..438	CDD:278523	6/28 (21%)
		C2H2 Zn finger	418..438	CDD:275368	6/26 (23%)
		zf-C2H2	443..465	CDD:278523	7/40 (18%)
		C2H2 Zn finger	445..465	CDD:275368	7/38 (18%)
		C2H2 Zn finger	474..491	CDD:275368	4/16 (25%)
		C2H2 Zn finger	504..521	CDD:275368	2/21 (10%)
ZNF518B	NP_001362745.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..36		5/10 (50%)
		C2H2 Zn finger	137..157	CDD:275368	3/19 (16%)
		zf-H2C2_5	164..186	CDD:372805	6/25 (24%)
		C2H2 Zn finger	164..184	CDD:275368	5/23 (22%)
		C2H2 Zn finger	192..213	CDD:275368	2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	678..704
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930