DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12391 and ZNF202

DIOPT Version :9

Sequence 1:NP_610639.1 Gene:CG12391 / 36170 FlyBaseID:FBgn0033581 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_001288708.1 Gene:ZNF202 / 7753 HGNCID:12994 Length:648 Species:Homo sapiens


Alignment Length:615 Identity:128/615 - (20%)
Similarity:208/615 - (33%) Gaps:174/615 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GEQRQNPQESAQNQE--QPQPRQ-------DLAGKSVGSADDGVSGTVGQIMDYLED-------- 60
            |::.::.:|:....|  |.|||:       .:.|:.|.|.:....|...:..:.|:|        
Human   108 GQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVHGQEVLSEETVHLGVEPESPNELQDPVQSSTPE 172

  Fly    61 ----------DAGATADQDAEMGEAEYLDGEMPQEDESETPQTEKANEGCQESSNK--------- 106
                      |.||.|:|.....|      |:....|||.|..|..:...:.||..         
Human   173 QSPEETTQSPDLGAPAEQRPHQEE------ELQTLQESEVPVPEDPDLPAERSSGDSEMVALLTA 231

  Fly   107 --------KDLQESAAKDDFSKEKSGEDGEKDTDKEKKATH----LHED------------NNDD 147
                    ||:....::|.:|          |.|..:|..:    |.||            ..|:
Human   232 LSQGLVTFKDVAVCFSQDQWS----------DLDPTQKEFYGEYVLEEDCGIVVSLSFPIPRPDE 286

  Fly   148 AEKDGDE----ADAEDEDDVEKPEDEDGTEEGDEAIEEDEDALDEDEDPNEEVEEI---EPDFET 205
            ..:..:|    .|.::..:.::||....|..||.: :::|:.|::::...|::...   ||:...
Human   287 ISQVREEEPWVPDIQEPQETQEPEILSFTYTGDRS-KDEEECLEQEDLSLEDIHRPVLGEPEIHQ 350

  Fly   206 GTDAEGELITGDEPGDLAD-------------VPIRERKKEEPV--DEDQCRVC----TSKEELV 251
            ..|  .|::..|.||.|.:             |.:||.....|:  ....|.||    |....||
Human   351 TPD--WEIVFEDNPGRLNERRFGTNISQVNSFVNLRETTPVHPLLGRHHDCSVCGKSFTCNSHLV 413

  Fly   252 CLFKKQIDATPADMLLVICPNVSILPKDFMPQFICTKCMGSLTIAIQLRKQLETTDQELRKRLSR 316
            ...:......|                     :.|.:|..|.|.:..|.:.             :
Human   414 RHLRTHTGEKP---------------------YKCMECGKSYTRSSHLARH-------------Q 444

  Fly   317 SKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGR 381
            ..:|:..|..|.:          :...|::...|:....|.|.:.... .||..|..:......|
Human   445 KVHKMNAPYKYPL----------NRKNLEETSPVTQAERTPSVEKPYR-CDDCGKHFRWTSDLVR 498

  Fly   382 PRKKPLKRGTDSDGEP--------SSAQKKKYQPSSTASVG--PFECPNCDLTFSRKQSYVLHRK 436
            .::      |.:..:|        |.:||..........:|  |:.|..|...||..:.|:.|||
Human   499 HQR------THTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRK 557

  Fly   437 THERIE-HACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAELKHHMAQRHDEHGF 500
            ||...| :.|..||:.|....|:..|::.|...|. .||..|.|.|..|..|..|......|..|
Human   558 THAAEELYLCSECGRCFTHSAAFAKHLRGHASVRP-CRCNECGKSFSRRDHLVRHQRTHTGEKPF 621

  Fly   501 IYECKRCQRTFLTQQRLQRHQAVGCQRHKE 530
              .|..|.::|.....|.|||    :.|.|
Human   622 --TCPTCGKSFSRGYHLIRHQ----RTHSE 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12391NP_610639.1 zf-AD 240..313 CDD:285071 12/76 (16%)
zf-C2H2 416..438 CDD:278523 8/21 (38%)
C2H2 Zn finger 418..438 CDD:275368 8/19 (42%)
zf-C2H2 443..465 CDD:278523 6/21 (29%)
C2H2 Zn finger 445..465 CDD:275368 6/19 (32%)
C2H2 Zn finger 474..491 CDD:275368 6/16 (38%)
C2H2 Zn finger 504..521 CDD:275368 5/16 (31%)
ZNF202NP_001288708.1 SCAN 43..153 CDD:128708 10/44 (23%)
SCAN 43..130 CDD:280241 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..221 17/80 (21%)
KRAB 237..297 CDD:214630 12/69 (17%)
KRAB 237..277 CDD:279668 10/49 (20%)
COG5048 397..>644 CDD:227381 66/304 (22%)
C2H2 Zn finger 399..419 CDD:275368 6/19 (32%)
zf-H2C2_2 411..436 CDD:290200 6/45 (13%)
C2H2 Zn finger 427..447 CDD:275368 5/32 (16%)
C2H2 Zn finger 483..503 CDD:275368 4/25 (16%)
zf-H2C2_2 495..520 CDD:290200 4/30 (13%)
C2H2 Zn finger 511..531 CDD:275368 3/19 (16%)
C2H2 Zn finger 539..559 CDD:275368 8/19 (42%)
C2H2 Zn finger 567..587 CDD:275368 6/19 (32%)
zf-C2H2 593..615 CDD:278523 8/21 (38%)
C2H2 Zn finger 595..615 CDD:275368 7/19 (37%)
zf-H2C2_2 607..632 CDD:290200 7/26 (27%)
C2H2 Zn finger 623..643 CDD:275368 7/23 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156918
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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