DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZNF79

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_009066.2	Gene:	ZNF79 / 7633	HGNCID:	13153	Length:	498	Species:	Homo sapiens

Alignment Length:	416	Identity:	91/416 - (21%)
Similarity:	144/416 - (34%)	Gaps:	101/416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 EEGDEAIEEDEDALDEDEDPNEEVEEIEPDFETGTDAEGELITGDEPGD--LADVPI---RERKK 232
            |||  .:.....||.::|:..||          |..|  .|:|....|.  .:.|.:   :||.:
Human     3 EEG--VLPSPGPALPQEENTGEE----------GMAA--GLLTAGPRGSTFFSSVTVAFAQERWR 53

  Fly   233 EEPVDEDQCRVCTSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMPQFICTKCMGSLTIAI 297
                    |.|.|.::.    ||:.|......::|:..|             :....|.|
Human    54 --------CLVSTPRDR----FKEGIPGKSRSLVLLGLP-------------VSQPGMNS----- 88

  Fly   298 QLRKQ-----LETTDQELRKRLSRSKNKVRRPR-GYVVIDAPVTDSSEDEDELDDEFKVSDVAGT 356
            ||.::     ||..|             :|.|. |:.:|.....:.:..|....|     .....
Human    89 QLEQREGAWMLEGED-------------LRSPSPGWKIISGSPPEQALSEASFQD-----PCVEM 135

  Fly   357 TSADSDSADSDDSEKEKKKP--GPRGR--PRKKPLKRGTDSDGEPSSAQKKKYQPSSTASVGPFE 417
            ...|||...||..:....:|  .|:.|  ...:|.|..|.::...:|...|.::..      |:.
Human   136 PPGDSDHGTSDLEKSFNLRPVLSPQQRVPVEARPRKCETHTESFKNSEILKPHRAK------PYA 194

  Fly   418 CPNCDLTFSRKQSYVLHRKTH--ERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKI 480
            |..|...||...|...|:|:|  |: .:.|..|||.|....:...|.:.|..|:. ::|..|.:.
Human   195 CNECGKAFSYCSSLSQHQKSHTGEK-PYECSECGKAFSQSSSLIQHQRIHTGEKP-YKCSECGRA 257

  Fly   481 FRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAVGCQRHKEDSVRIKEEQSRFKQE 545
            |...|.|..|......|..  |.|..|::.|.....|.:||            ||...:..::..
Human   258 FSQNANLTKHQRTHTGEKP--YRCSECEKAFSDCSALVQHQ------------RIHTGEKPYECS 308

  Fly   546 SRSKDDRHHGNNSSKRRPGEGRDLFK 571
            ...|..||..|.::.:|...|...:|
Human   309 DCGKAFRHSANLTNHQRTHTGEKPYK 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	15/77 (19%)
		zf-C2H2	416..438	CDD:278523	7/21 (33%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-C2H2	443..465	CDD:278523	6/21 (29%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	4/16 (25%)
ZNF79	NP_009066.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		6/21 (29%)
		KRAB	40..98	CDD:214630	15/87 (17%)
		KRAB_A-box	40..77	CDD:143639	9/48 (19%)
		C2H2 Zn finger	172..189	CDD:275368	3/16 (19%)
		C2H2 Zn finger	195..215	CDD:275368	7/19 (37%)
		COG5048	<206..437	CDD:227381	36/145 (25%)
		zf-H2C2_2	207..232	CDD:290200	10/25 (40%)
		C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		zf-H2C2_2	235..260	CDD:290200	6/25 (24%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		zf-H2C2_2	263..287	CDD:290200	6/25 (24%)
		C2H2 Zn finger	279..299	CDD:275368	7/31 (23%)
		zf-H2C2_2	291..316	CDD:290200	6/36 (17%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:290200	4/16 (25%)
		C2H2 Zn finger	335..355	CDD:275368	91/416 (22%)
		zf-H2C2_2	350..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368
		zf-H2C2_2	375..400	CDD:290200
		C2H2 Zn finger	391..411	CDD:275368
		zf-H2C2_2	403..427	CDD:290200
		C2H2 Zn finger	419..439	CDD:275368
		zf-H2C2_2	431..456	CDD:290200
		C2H2 Zn finger	447..467	CDD:275368
		zf-H2C2_2	459..484	CDD:290200
		C2H2 Zn finger	475..495	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8290
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950