DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and SNAI1

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_005976.2	Gene:	SNAI1 / 6615	HGNCID:	11128	Length:	264	Species:	Homo sapiens

Alignment Length:	184	Identity:	48/184 - (26%)
Similarity:	73/184 - (39%)	Gaps:	27/184 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 ADSDSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSDGEPSSAQKKKYQ--------PSSTASVG- 414
            |:..|...:||.|..:.|.|   |...|   .:.|....||.:.:.|.        |...|.:.
Human    86 AELTSLSDEDSGKGSQPPSP---PSPAP---SSFSSTSVSSLEAEAYAAFPGLGQVPKQLAQLSE 144

  Fly   415 --------PFECPNCDLTFSRKQSYVLHRKTHERIEHACPICGKKFKVEWAYKTHMQRHEQERAH 471
                    .|.|..|:..:....:..:|.::| .:...|..|||.|...|..:.|::.|..|:.
Human   145 AKDLQARKAFNCKYCNKEYLSLGALKMHIRSH-TLPCVCGTCGKAFSRPWLLQGHVRTHTGEKP- 207

  Fly   472 FRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAVGC 525
            |.|..|.:.|..|:.|:.|:....|...  |:|:.|.|||.....|.:||..||
Human   208 FSCPHCSRAFADRSNLRAHLQTHSDVKK--YQCQACARTFSRMSLLHKHQESGC 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071
		zf-C2H2	416..438	CDD:278523	4/21 (19%)
		C2H2 Zn finger	418..438	CDD:275368	3/19 (16%)
		zf-C2H2	443..465	CDD:278523	7/21 (33%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	6/16 (38%)
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SNAG domain. /evidence=ECO:0000305\|PubMed:20389281, ECO:0000305\|PubMed:21300290	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:23721412	2..7
		LATS2 binding	10..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..115		9/34 (26%)
		Destruction motif	95..100		3/4 (75%)
		Required for FBXL14-triggered degradation	120..151		4/30 (13%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269\|PubMed:21577210, ECO:0000269\|PubMed:22128911	151..264		33/113 (29%)
		C2H2 Zn finger	156..176	CDD:275368	3/19 (16%)
		C2H2 Zn finger	182..202	CDD:275368	7/19 (37%)
		zf-H2C2_2	195..218	CDD:404364	6/23 (26%)
		zf-C2H2	208..230	CDD:395048	7/21 (33%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		C2H2 Zn finger	238..255	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100