DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZSCAN18

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001139014.1	Gene:	ZSCAN18 / 65982	HGNCID:	21037	Length:	566	Species:	Homo sapiens

Alignment Length:	345	Identity:	75/345 - (21%)
Similarity:	110/345 - (31%)	Gaps:	113/345 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 EKPEDEDG---TEEGDEAIEEDEDALDE--DEDPNEE------------VEEIEPDFETGTDAEG 211
            |...:|||   ||:..::..||...|.|  ..||.||            .:..:||..:..|.|.
Human   257 EAKTEEDGPANTEQKLKSFPEDPQHLGEWGHLDPAEENLKSYRKLLLWGYQLSQPDAASRLDTEE 321

  Fly   212 -ELITGDEPGDLADVPIRERKKEEPVDEDQCRVCTSKEELVCLFKKQIDATPADMLLVICPNVSI 275
             .|:..|..|  :.:|...|::|.       ..|..:|           |.||          .:
Human   322 LRLVERDPQG--SSLPEGGRRQES-------AGCACEE-----------AAPA----------GV 356

  Fly   276 LPKDFMPQFICTKCMGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSED 340
            ||:  :|                                      ...|.|..:.|.|   |...
Human   357 LPE--LP--------------------------------------TEAPPGDALADPP---SGTT 378

  Fly   341 EDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSDGEPSSAQKKKY 405
            |:|.:...|..|......|:||||.....:...::|.|.....|...||....||:..|.:...
Human   379 EEEEEQPGKAPDPQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSLEGVS- 442

  Fly   406 QPSSTASVG------------------PFECPNCDLTFSRKQSYVLHRKTH-ERIEHACPICGKK 451
              ||..|.|                  |:.|..|...|:.....:.|..:| .|..:||..|.|.
Human   443 --SSGDSAGLEAGQGPGADEPGLSRGKPYACGECGEAFAWLSHLMEHHSSHGGRKRYACQGCWKT 505

  Fly   452 FKVEWAYKTHMQRHEQERAH 471
            |....|...|.:.||:|:::
Human   506 FHFSLALAEHQKTHEKEKSY 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	8/72 (11%)
		zf-C2H2	416..438	CDD:278523	4/21 (19%)
		C2H2 Zn finger	418..438	CDD:275368	4/19 (21%)
		zf-C2H2	443..465	CDD:278523	7/21 (33%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..491	CDD:275368
		C2H2 Zn finger	504..521	CDD:275368
ZSCAN18	NP_001139014.1	SCAN	102..189	CDD:280241
		KRAB	<284..321	CDD:214630	8/36 (22%)
		C2H2 Zn finger	471..491	CDD:275368	4/19 (21%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156930
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930