DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12391 and ZNF446

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_060378.1	Gene:	ZNF446 / 55663	HGNCID:	21036	Length:	450	Species:	Homo sapiens

Alignment Length:	164	Identity:	40/164 - (24%)
Similarity:	63/164 - (38%)	Gaps:	39/164 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 PGPRGRPRKKPLKRGTDSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQSYVLHRKTH-- 438
            |.|..||...|:..      :|:.|: .:.:|::|.. .|:.|..|...|..|..:|:|.:||
Human   300 PAPTVRPGTPPVPT------QPTPAE-TRLEPAATPR-KPYTCEQCGRGFDWKSVFVIHHRTHTS 356

  Fly   439 ------------ERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAEL---- 487
                        |..|       |..:.|.|:..|.:|.......:.||.|...|..:::|
Human   357 GPGVQSPGLATGESTE-------KPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHR 414

  Fly   488 KHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQ 521
            |.|..||.      :.|..|.|.|..:.:|..|:
Human   415 KSHTGQRR------HFCSDCGRAFDWKSQLVIHR 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071
		zf-C2H2	416..438	CDD:278523	6/21 (29%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	4/21 (19%)
		C2H2 Zn finger	445..465	CDD:275368	4/19 (21%)
		C2H2 Zn finger	474..491	CDD:275368	6/20 (30%)
		C2H2 Zn finger	504..521	CDD:275368	5/16 (31%)
ZNF446	NP_060378.1	SCAN	22..137	CDD:128708
		SCAN	22..110	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..155
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..205
		KRAB	<209..237	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..331		9/38 (24%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..389		8/41 (20%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	410..432	CDD:290200	8/27 (30%)
		C2H2 Zn finger	425..445	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930