DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZNF444

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_060807.2	Gene:	ZNF444 / 55311	HGNCID:	16052	Length:	327	Species:	Homo sapiens

Alignment Length:	284	Identity:	72/284 - (25%)
Similarity:	106/284 - (37%)	Gaps:	72/284 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 LLVICPNVSILPKDFMPQFICTKCMGSLTIAIQLRKQL----ETTDQELRKRLSRSKNKVRRPRG 326
            |||:...:|.||.| ...::|::...|...|:.|.::|    .:.|.....|:.:.
Human    62 LLVLEQFLSALPAD-TQAWVCSRQPQSGEEAVALLEELWGPAASPDGSSATRVPQD--------- 116

  Fly   327 YVVIDAP-VTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPLKRG 390
              |...| .|...||...:       .:|||...             .:.|.|......:|.|:
Human   117 --VTQGPGATGGKEDSGMI-------PLAGTAPG-------------AEGPAPGDSQAVRPYKQ- 158

  Fly   391 TDSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQSYVL-HRKTHE-RIEHACPICGKKFK 453
                 ||||.......|:..|:.|...||.|..| |.|.:::| ||::|. ...||||.|||.|:
Human   159 -----EPSSPPLAPGLPAFLAAPGTTSCPECGKT-SLKPAHLLRHRQSHSGEKPHACPECGKAFR 217

  Fly   454 VEWAYKTHMQRHE-------------------QERAHFRCELCPKIFRLRAELKHHMAQRHDEHG 499
                .|.|::||.                   :|:.|..|| |.|.|..|..|..|.........
Human   218 ----RKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCE-CGKTFYWREHLVRHRKTHSGARP 277

  Fly   500 FIYECKRCQRTFLTQQRLQRHQAV 523
            |  .|..|.:.|..::.:.|||.:
Human   278 F--ACWECGKGFGRREHVLRHQRI 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	13/50 (26%)
		zf-C2H2	416..438	CDD:278523	9/22 (41%)
		C2H2 Zn finger	418..438	CDD:275368	9/20 (45%)
		zf-C2H2	443..465	CDD:278523	10/21 (48%)
		C2H2 Zn finger	445..465	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..491	CDD:275368	7/16 (44%)
		C2H2 Zn finger	504..521	CDD:275368	4/16 (25%)
ZNF444	NP_060807.2	SCAN	21..98	CDD:366881	11/36 (31%)
		PRK14959	<60..>182	CDD:184923	33/157 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..171		18/106 (17%)
		COG5048	<179..>280	CDD:227381	33/108 (31%)
		C2H2 Zn finger	181..201	CDD:275368	9/20 (45%)
		C2H2 Zn finger	209..229	CDD:275368	10/23 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..243		3/22 (14%)
		C2H2 Zn finger	252..272	CDD:275368	8/20 (40%)
		zf-C2H2	278..300	CDD:333835	7/24 (29%)
		C2H2 Zn finger	280..300	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930