DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	408	Identity:	86/408 - (21%)
Similarity:	146/408 - (35%)	Gaps:	115/408 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KDGDEADAED--EDDVEKPEDEDGTEEGDEAIEEDEDALDEDEDPNEEVEEIE-----PD---FE 204
            ::|.:.:|.:  ..:.|..|.||||.:|.:..|:|      ..:|.:||.:::     |:   ||
Human   356 QEGSDIEAGELNHQNGEPTEVEDGTVDGADRDEKD------FRNPGQEVRKLDLPVLFPNRLGFE 414

  Fly   205 TGTDAEGELITGDEPGDLADVPIRERK--------------KEEPVDEDQCRVCTSKEELVCLFK 255
            ...:.:.|.:..|:..::......:||              :.||....|||....:.|
Human   415 FKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNSPGESE------ 473

  Fly   256 KQIDATPADMLLVICPNVSILPKD-FMPQFICTK-CMGSLTIAIQLRKQLETTDQ--ELRKRLSR 316
               :.||:...:   .:.|...:| .....:|.| |..|:....:...:||...|  |..|..||
Human   474 ---EKTPSQEKM---SHQSFCARDKACTHILCGKNCSQSVHSPHKPALKLEKVSQCPECGKTFSR 532

  Fly   317 SKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGR 381
            |...||..|.:.
Human   533 SSYLVRHQRIHT----------------------------------------------------- 544

  Fly   382 PRKKPLKRGTDSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQSYVLHRKTH--ERIEHA 444
             .:||.|......|....:....:..:.|.. .|::|..|..:|::..|.::|::||  |: .:.
Human   545 -GEKPHKCSECGKGFSERSNLTAHLRTHTGE-RPYQCGQCGKSFNQSSSLIVHQRTHTGEK-PYQ 606

  Fly   445 CPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIF----RLRAELKHHMAQRHDEHGFIYECK 505
            |.:|||:|.....:..|.:.|..| :.::|.:|.|||    ...|..|.|..::.      |.|.
Human   607 CIVCGKRFNNSSQFSAHRRIHTGE-SPYKCAVCGKIFNNSSHFSAHRKTHTGEKP------YRCS 664

  Fly   506 RCQRTFLTQQRLQRHQAV 523
            .|:|.|.....|.|||.|
Human   665 HCERGFTKNSALTRHQTV 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	16/76 (21%)
		zf-C2H2	416..438	CDD:278523	5/21 (24%)
		C2H2 Zn finger	418..438	CDD:275368	5/19 (26%)
		zf-C2H2	443..465	CDD:278523	6/21 (29%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..491	CDD:275368	7/20 (35%)
		C2H2 Zn finger	504..521	CDD:275368	6/16 (38%)
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		8/39 (21%)
		COG5048	<455..668	CDD:227381	58/287 (20%)
		zf-C2H2	522..543	CDD:278523	9/20 (45%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		zf-H2C2_2	535..559	CDD:290200	7/77 (9%)
		C2H2 Zn finger	551..571	CDD:275368	1/19 (5%)
		zf-H2C2_2	563..588	CDD:290200	5/25 (20%)
		C2H2 Zn finger	579..599	CDD:275368	5/19 (26%)
		zf-H2C2_2	591..616	CDD:290200	10/25 (40%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	8/21 (38%)
		C2H2 Zn finger	635..655	CDD:275368	7/19 (37%)
		zf-H2C2_2	647..671	CDD:290200	7/29 (24%)
		zf-C2H2	661..683	CDD:278523	10/22 (45%)
		C2H2 Zn finger	663..683	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930