DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and CG11902

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	87/409 - (21%)
Similarity:	137/409 - (33%)	Gaps:	140/409 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 DQCRVCTSKEELV-----CLFK---KQIDATPADMLLVICPNVSILPKDFMPQFICTKCMGSLTI 295
            |.||.|..:...:     ||.|   |...|...::..:...|..    |.:||.||::|...:..
  Fly     5 DVCRTCAVQNSQLLPLSTCLDKDSSKSYYAVLQELTQIDLENTD----DNLPQHICSECWRRMES 65

  Fly   296 AIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDD-----EFKVSDVAG 355
            |....:|......||..:|....::       :.||.|...:.:.|.:|||     |.:|.|...
  Fly    66 AYTFVQQARKVHGELLAQLRECLDE-------LPIDIPAEQNIKTEVDLDDGGNKSEVEVDDTEA 123

  Fly   356 TT-------SADSD-----SADSDDSEKEKKKPGPRGRPRKKPLKRGTDSD------GEPSSAQK 402
            |.       ::.||     ..:||:.:.|||....|...||  :|...:|:      .|||..::
  Fly   124 TALELKWQPASGSDREFCSGPESDEDQVEKKSYHLRRSSRK--VKHPVESENEECKPSEPSPVKR 186

  Fly   403 KKYQPSSTA------SVGPFECPNCDLTFSRKQSYVLHRKTH-ERIEHACPICGKKFKVEWAYKT 460
            ::.:|...|      :.|...|..|..|||..:....|.:.| |...:.|..|||.|..:..|..
  Fly   187 RRGRPPGPAKSQAMTTDGRHACEVCGKTFSWYRDMQRHARIHFENASYVCDTCGKGFLRKDKYIF 251

  Fly   461 HMQRHEQERAHFR------------------------CEL----CPKIFRLRAELKHH------- 490
            |::.|::..|.::                        |:|    |.::..|||.|..|
  Fly   252 HLRCHKKREAKWKALQLGKEWRFAERLYSSGKLKRIECKLCGLSCQRMEELRAHLWDHADTETLV 316

  Fly   491 ------------------------------MAQRHDE--------HGF----------------I 501
                                          :|..|.|        ||:                .
  Fly   317 NLRTDSDVVREHFPGLPCDLDNIKKQICVDIADGHLEKYACVVNFHGYELGLSDSDEECDSKESK 381

  Fly   502 YECKRCQRTFLTQQRLQRH 520
            |.|..|..:|..:.||.:|
  Fly   382 YHCFVCNMSFNRKHRLMKH 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	19/80 (24%)
		zf-C2H2	416..438	CDD:278523	6/21 (29%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	7/21 (33%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..491	CDD:275368	8/57 (14%)
		C2H2 Zn finger	504..521	CDD:275368	6/17 (35%)
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071	19/80 (24%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..405	CDD:275368	6/17 (35%)
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368
		C2H2 Zn finger	896..918	CDD:275368
		C2H2 Zn finger	926..947	CDD:275368
		C2H2 Zn finger	967..987	CDD:275368
		C2H2 Zn finger	996..1016	CDD:275368
		C2H2 Zn finger	1044..1063	CDD:275368
		C2H2 Zn finger	1224..1244	CDD:275368
		C2H2 Zn finger	1271..1291	CDD:275368
		zf-H2C2_2	1283..1306	CDD:290200
		COG5048	1295..>1367	CDD:227381
		C2H2 Zn finger	1299..1319	CDD:275368
		zf-H2C2_2	1311..1336	CDD:290200
		C2H2 Zn finger	1327..1347	CDD:275368
		zf-H2C2_2	1340..1364	CDD:290200
		C2H2 Zn finger	1355..1375	CDD:275368
		zf-H2C2_2	1367..1392	CDD:290200
		C2H2 Zn finger	1383..1401	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010