DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12391 and su(Hw)

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	143/676 - (21%)
Similarity:	229/676 - (33%)	Gaps:	200/676 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AETNGEQRQNPQESAQN-----QEQPQPRQDLAGKSVGSADD---GVSGTVGQIMDYLEDDAGAT 65
            |...|::::......:|     .::|..|..|. ..||:.:|   ..:.|..:.....::..|:.
  Fly     3 ASKEGKEKKGKLLGVENISPPKDKRPATRMKLL-NDVGAGEDSEASTTTTTSRTPSNKQEKRGSV 66

  Fly    66 ADQDAEMGEAEYLDGEMPQEDESETPQTEKANEGCQES-----------SNKKDLQESAAKDDFS 119
            |....::...|.|.          ||:|||  .|..:|           :.||....:....:.:
  Fly    67 AGSRIKILNEEILG----------TPKTEK--RGATKSTAPAASTVKILNEKKTPSATVTAVETT 119

  Fly   120 KEKSGEDGEKDTDKEKKATH--LHEDNNDDAEKDGDEADAEDEDDVEK---PEDED------GTE 173
            |.|:      ...|.||..|  |....:::.:.|.......:|||...   .:||:      ...
  Fly   120 KIKT------SPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENN 178

  Fly   174 EGDEAI--EEDEDALDEDEDPNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKEEPV 236
            .|.|.:  |:||| |.||.|            |.|.|:.|:       |:.:...|:|      :
  Fly   179 NGQEIVVTEDDED-LGEDGD------------EDGEDSSGK-------GNSSQTKIKE------I 217

  Fly   237 DEDQCRVCTSKEELVCLFKKQID---------ATPADMLL------------------------- 267
            .|..|..|......|...||.::         ...||||.
  Fly   218 VEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESY 282

  Fly   268 -------VICPNVSILPKDFMPQ----------------FICTKCMGSLTIAIQLRKQLETTDQE 309
                   :.||:   .||.|..|                |.|:.|..:|.             .|
  Fly   283 DTFHLGHINCPD---CPKSFKTQTSYERHIFITHSEFSDFPCSICNANLR-------------SE 331

  Fly   310 LRKRLSRSKNKVR-RPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEK 373
            ....|...::|.| :|....:.....|.|.    .|....|.|           |..|::::...
  Fly   332 ALLALHEEQHKSRGKPYACKICGKDFTRSY----HLKRHQKYS-----------SCSSNETDTMS 381

  Fly   374 KKPGPRGRPR----KKPLKR--GTDSDGEPS---SAQKKKYQPSSTASV--------GPFECPNC 421
            .|...|...|    :..||:  ||....:|.   ...|..:...||.::        .||:|..|
  Fly   382 CKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLC 446

  Fly   422 DLTFSRKQSYVLHRKTH--ERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIF--- 481
            |..||...:...||:.|  |: .::|.:|.:.|.|:.....||:||..||.| :|:.|.|.|
  Fly   447 DKKFSALVALKKHRRYHTGEK-PYSCTVCNQAFAVKEVLNRHMKRHTGERPH-KCDECGKSFIQA 509

  Fly   482 -RLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAVGCQRHKEDSVRIKEEQSRFKQE 545
             :||...|.|:..        :.|::|...|.|:::|:||.... .|.|.......|.:..|:..
  Fly   510 TQLRTHSKTHIRP--------FPCEQCDEKFKTEKQLERHVKTH-SRTKRPVFSCAECKRNFRTP 565

  Fly   546 SRSKDDRHHGNNSSKRRPGEGRDLFK 571
            :..|:....|.:|.|::....|...|
  Fly   566 ALLKEHMDEGKHSPKQQRSSMRSAVK 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	20/129 (16%)
		zf-C2H2	416..438	CDD:278523	8/21 (38%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-C2H2	443..465	CDD:278523	6/21 (29%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..491	CDD:275368	7/20 (35%)
		C2H2 Zn finger	504..521	CDD:275368	6/16 (38%)
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/23 (26%)
		COG5048	<312..517	CDD:227381	55/234 (24%)
		C2H2 Zn finger	321..341	CDD:275368	5/32 (16%)
		zf-C2H2	348..368	CDD:278523	3/23 (13%)
		C2H2 Zn finger	350..368	CDD:275368	3/21 (14%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	3/19 (16%)
		zf-H2C2_2	428..451	CDD:290200	5/22 (23%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)
		zf-H2C2_2	455..479	CDD:290200	6/24 (25%)
		COG5048	<467..620	CDD:227381	36/136 (26%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	11/24 (46%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..572	CDD:275368	3/16 (19%)
		C2H2 Zn finger	598..615	CDD:275371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010