DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and znf131

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_956799.2	Gene:	znf131 / 393477	ZFINID:	ZDB-GENE-040426-1563	Length:	558	Species:	Danio rerio

Alignment Length:	271	Identity:	68/271 - (25%)
Similarity:	101/271 - (37%)	Gaps:	54/271 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 AIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSS--EDEDELDDE---------FK 349
            |:..|:...|:.|..:.:  ..|.|:......:....|..|:.  |.|.|:.:|         .:
Zfish   120 ALNNRRNGTTSPQPGKSK--AKKRKISETSNVITESLPSADTEAVEIEVEVGEEHIEVEESGLVE 182

  Fly   350 VSDVA-GTTSADSDSAD----SDDSEKEKKKPGPRGRPRKKPLKRGTDS---DGEPSSAQKK--- 403
            |.||| |||...||.:.    :|.:.|.:     :|......:|:..::   ..|...|.|.
Zfish   183 VVDVARGTTVPSSDDSALALLADITSKYQ-----QGEQTLHVIKKVDETVVVQEEAVVASKTLEN 242

  Fly   404 ----KYQPSSTASVGPFECPNCDLTFSRKQSYVLHRKTH----ERIEHACPICGKKFKVEWAYKT 460
                :.|.|...::  |.|..||..|........|.|||    || ...|..|||.:..|.|.|.
Zfish   243 IEVVEVQISQLDNL--FRCDKCDRCFKLYYHLKQHMKTHIASPER-GFVCRHCGKAYAREGALKQ 304

  Fly   461 HM----------QRHEQERAHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQ 515
            |:          .|.::::.|. ||.|.|.|......|.|:.:...|..|  ||..|...|....
Zfish   305 HLNNYHFDAEEQSRRQKKKVHV-CEYCEKQFDHFGHFKEHLRKHTGEKPF--ECPECHERFARNS 366

  Fly   516 RLQRHQAVGCQ 526
            .|:.|.: .||
Zfish   367 TLKCHMS-ACQ 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	4/16 (25%)
		zf-C2H2	416..438	CDD:278523	7/21 (33%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	8/31 (26%)
		C2H2 Zn finger	445..465	CDD:275368	8/29 (28%)
		C2H2 Zn finger	474..491	CDD:275368	6/16 (38%)
		C2H2 Zn finger	504..521	CDD:275368	4/16 (25%)
znf131	NP_956799.2	BTB	24..120	CDD:306997	68/271 (25%)
		zf-C2H2	257..279	CDD:306579	7/21 (33%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..347	CDD:275368	17/58 (29%)
		COG5048	<310..441	CDD:227381	19/71 (27%)
		C2H2 Zn finger	327..344	CDD:275368	6/16 (38%)
		zf-H2C2_2	339..364	CDD:316026	8/26 (31%)
		C2H2 Zn finger	355..372	CDD:275368	4/16 (25%)
		C2H2 Zn finger	419..439	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930