DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12391 and CG11696

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	657	Identity:	141/657 - (21%)
Similarity:	228/657 - (34%)	Gaps:	205/657 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TPLAETNGEQRQNPQESAQNQEQP-QPRQDLAGKSVGSADDGVSGTVGQIMDYL-----EDDAGA 64
            |.|.|........|.....|.|.| :|:....|      ||        |.|::     .|...|
  Fly    86 TELPELPELTEPEPALVVWNTESPIEPKLSYEG------DD--------IKDHILCEPVIDALSA 136

  Fly    65 TADQDAEMGEAEYLDGE-MPQEDESETPQTEKANEGCQESSNKKDLQES--AAKDDFSKEKSGED 126
            ..::|::.|:....|.| ..|.||.|.|:.:......:....|..||::  ..|..:.|.|. ::
  Fly   137 GDEKDSDYGDTFEPDFEPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQIIKRKYEKRKQ-QN 200

  Fly   127 GEKDTDKEKKATHLHEDNNDDAEKDGDEADAEDEDDVEKPEDEDGTEEGDEAIEEDEDALDEDED 191
            ..|.|:     ..|.|......|.....|.|||        |:||.|:     ||||:.:..:..
  Fly   201 KAKITE-----LSLRESRARQRELKRSSAGAED--------DQDGDED-----EEDEEDVGGELT 247

  Fly   192 PNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKEEPVD------EDQCRVCTSKEEL 250
            |:.: |:.:|..:.|.....:|:|.|:..|.::||::....:|..|      :..|.:|
  Fly   248 PDAD-EQPKPRGKRGRPKTKKLVTADDNDDTSEVPVKRSSIKEMDDYIAANVKLDCAIC------ 305

  Fly   251 VCLFKKQIDATPADMLLVICPNVSILPKDFMPQFICT---KCMGSLTIAIQLRKQLETTD----- 307
                     |.|.:       :.:.|.:.|..:..||   ||..:     :.:|:....|
  Fly   306 ---------AAPLE-------DFNDLKRHFRVEHDCTGYVKCCNN-----RYKKRTLYVDHLHCH 349

  Fly   308 --------QELRKR-LSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDS 363
                    |..||. |:|:...:...|.:           ..:.||..:..:.:
  Fly   350 KDPQYFSCQSCRKNFLNRNSQVMHMLRFH-----------SQQQELVHQCAICE----------- 392

  Fly   364 ADSDDSEKEKKKPGPRGRPRKKPL-------KRGTDSDGEP------SSAQKKKYQPSS------ 409
                            .|..||.|       .:||:   .|      |...:.|::.|:
  Fly   393 ----------------ARFAKKFLLTMHLKGHKGTE---RPEVCDTCSKTFRTKFELSAHVKRMH 438

  Fly   410 TASVGPFECPNCDLTFSRKQSYVLHRKT-HER---IEHACPICGKKFKVEWAYKTHMQRHEQE-- 468
            .|...|..|..|...|..|.::::|:|. |..   .|..|.:||:..:.|.:.:.|:.||:..
  Fly   439 AADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDG 503

  Fly   469 RAHFRCELCPKIFRLRAELK-----HHMAQRHD---------------EH-----GF-IYECKRC 507
            ...:||.||......||.|.     ||.|:||.               ||     |. :|:|:.|
  Fly   504 DTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLYQCQFC 568

  Fly   508 QRTFLTQQRLQRHQAVGCQRHKEDSVRIKEEQSRFKQESRSKDDR----HHGNNSSKRRPGEGRD 568
            .|||.:...:..|:.   :.|..|.||      ::.|.|.|....    .|.|:.::..|
  Fly   569 TRTFKSHANMHNHKK---KMHPNDWVR------KYSQPSSSITSTAAPLAHPNHPNQPAP----- 619

  Fly   569 LFKAVAP 575
              .|.||
  Fly   620 --PAAAP 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	14/88 (16%)
		zf-C2H2	416..438	CDD:278523	6/22 (27%)
		C2H2 Zn finger	418..438	CDD:275368	6/20 (30%)
		zf-C2H2	443..465	CDD:278523	5/21 (24%)
		C2H2 Zn finger	445..465	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..491	CDD:275368	7/21 (33%)
		C2H2 Zn finger	504..521	CDD:275368	5/16 (31%)
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	2/21 (10%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	4/46 (9%)
		C2H2 Zn finger	417..438	CDD:275368	3/20 (15%)
		C2H2 Zn finger	447..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	2/19 (11%)
		C2H2 Zn finger	565..583	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100