DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and Zfp518a

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001025209.1	Gene:	Zfp518a / 309478	RGDID:	1305314	Length:	1478	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	77/385 - (20%)
Similarity:	129/385 - (33%)	Gaps:	95/385 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 PVDEDQCRVCTSKEELVCLFKKQIDA---TPADMLLVICPNVSILPKDFMPQFICTKCMGSLTIA 296
            |.::.|. .|..|:.::    |:||.   .|..:..:..|.:|.....:.|:.: ..|:..:.|.
  Rat     2 PFEQTQL-FCDEKQTIL----KKIDTRNEIPDTIKSIPIPKISEAGFHYEPKNV-NICLPKINIP 60

  Fly   297 IQL---------RKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSD 352
            .::         ||..::..|..||.:|     ||
  Rat    61 NEILMKHEVEKYRKLFQSKPQTARKSVS-----VR------------------------------ 90

  Fly   353 VAGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPL-----KRGTDSDGEPSSAQKKKYQPSSTAS 412
               |.|.....|...:||:.:.:   .|:...|.|     |....:...|:..| |.::......
  Rat    91 ---TVSCAKGCAQRCESERAEDE---AGKMCAKILNFTCSKCQDRTQYSPNDLQ-KHFEMWHHGE 148

  Fly   413 VGPFECPNCDLTFSRKQSYVLHRKTHERIEHACPICGKKFKVEWAY-----KTHMQRHEQERAHF 472
            :..|.|..|..:.|..|.:..|||||......|.||..    |.:|     ..|.........:|
  Rat   149 LPSFPCEMCSFSASDFQIFKQHRKTHRNTFVKCDICNS----ERSYTLLDLTKHFTSKHCVNGNF 209

  Fly   473 RCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAVG----------CQR 527
            :||.|....:.......|:.:..:.|   |:|.:|.....|:..||:|..|.          |..
  Rat   210 QCEECRFFTQDVGTFVQHIHRHKEVH---YKCGKCHHLCFTKGELQKHLRVHSGTLPFTCHYCSY 271

  Fly   528 ---HKEDSVR---IKEEQSRFKQESRSKDDRHHGNNSSKRRPGEGRDLFKAVAPPTTTYW 581
               ||:..||   ...::..:.:|...:|  .:....:|...|....|.:....||.|:|
  Rat   272 GAIHKDQLVRHVITLHKEHLYAKEKLERD--QYDKRVAKTTTGLKLILKRYKIGPTKTFW 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	16/84 (19%)
		zf-C2H2	416..438	CDD:278523	8/21 (38%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-C2H2	443..465	CDD:278523	6/26 (23%)
		C2H2 Zn finger	445..465	CDD:275368	6/24 (25%)
		C2H2 Zn finger	474..491	CDD:275368	3/16 (19%)
		C2H2 Zn finger	504..521	CDD:275368	5/16 (31%)
Zfp518a	NP_001025209.1	C2H2 Zn finger	181..203	CDD:275368	6/25 (24%)
		C2H2 Zn finger	211..231	CDD:275368	4/19 (21%)
		C2H2 Zn finger	238..258	CDD:275368	6/19 (32%)
		C2H2 Zn finger	266..283	CDD:275368	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..394
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..484
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930