DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and Zfp641

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001100262.1	Gene:	Zfp641 / 300197	RGDID:	1310412	Length:	421	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	88/457 - (19%)
Similarity:	145/457 - (31%)	Gaps:	159/457 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DAEKDGDEADAEDED---DVEKPEDEDGTEEGDEAIEEDEDALDEDEDPNEEVEEIEPDFETGT- 207
            ||.:.|.|..|.:|.   ...:|     .|.....:|::..:|.|.......|..:..:.:||.
  Rat    21 DAAEPGSERGAREEGPWRTAPRP-----LEHLHSGLEDETLSLQEKAPSAPWVPAVPQEGDTGDW 80

  Fly   208 DAEGELITGDEPG--DLADVPIRERKKEEPVDEDQCRVCTSKEELVCLFKKQIDATPADMLLVIC 270
            :....|:.....|  .:.||.:                |.|:||...|...|
  Rat    81 EMAAALLAAGSQGLVTIKDVSL----------------CFSQEEWRSLDPSQ------------- 116

  Fly   271 PNVSILPKDFMPQFICTKCMGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVT 335
                   .||..:::..:..|   |.:.||..:...|.                       .|..
  Rat   117 -------TDFYGEYVMQENCG---IVVSLRFPIPKLDM-----------------------LPQL 148

  Fly   336 DSSEDE---DELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKP------------------GPR 379
            :..|::   |..|.|.:  |:...|.|........|:.:.:.:|                  ||.
  Rat   149 EGGEEQWVPDPQDVEGR--DIRKVTYAGDGGEPKGDTPELETEPSRTLSSMSEETVLWNPGQGPS 211

  Fly   380 GR----------PRKKPLK--------RGTDSDG--EPSSAQK-----------KKYQPSSTASV 413
            .|          ||.:.|:        |.||:|.  :|.:..:           .::|.:.|..
  Rat   212 WRSMPSSSTGTLPRPRFLQEDSVSHLLRSTDTDSLLKPHTCPQCGKQFVWGSHLARHQQTHTGE- 275

  Fly   414 GPFECPNCDLTFSRKQSYVLHRKTHERIEHA-CPICGKKFKVEWAYKTHMQRHEQERAHFR---- 473
            .|:.|..|:.:|.|:...:.|:|||...:.: ||.|||.|:.    .:|:..|::..|..:
  Rat   276 RPYSCLKCEKSFGRRHHLIRHQKTHLHDKPSRCPECGKTFRC----SSHLASHQRVHADSKSCKG 336

  Fly   474 --------------------CELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQ 518
                                |..|.|.|..|..|..|......|..|  .|.||:::|..:..|.
  Rat   337 QEIGESPGAQCAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPF--HCPRCEKSFGRKHHLD 399

  Fly   519 RH 520
            ||
  Rat   400 RH 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	13/72 (18%)
		zf-C2H2	416..438	CDD:278523	6/21 (29%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	7/22 (32%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..491	CDD:275368	6/16 (38%)
		C2H2 Zn finger	504..521	CDD:275368	7/17 (41%)
Zfp641	NP_001100262.1	PLN03206	<13..90	CDD:178745	15/73 (21%)
		KRAB	95..156	CDD:214630	17/122 (14%)
		COG5048	<208..402	CDD:227381	47/201 (23%)
		C2H2 Zn finger	252..272	CDD:275368	1/19 (5%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		C2H2 Zn finger	308..328	CDD:275368	8/23 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930