DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12391 and Plag1

DIOPT Version :9

Sequence 1:NP_610639.1 Gene:CG12391 / 36170 FlyBaseID:FBgn0033581 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_001008317.1 Gene:Plag1 / 297804 RGDID:1305286 Length:499 Species:Rattus norvegicus


Alignment Length:241 Identity:54/241 - (22%)
Similarity:85/241 - (35%) Gaps:64/241 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   366 SDDSEKEKKKPGPRGRPRKKPLKRGTDS--DGEPSSAQKKKYQPSSTASVGPFECPNCDLT--FS 426
            |:..:.:|...|.|.|...||.|.....  |...:|.:|.|....|.....|::|.:.|.|  |.
  Rat    10 SEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKAFV 74

  Fly   427 RKQSYVLHRKTHE-RIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAELKHH 490
            .|.....|..||. ...|.|..|.|.|..:...|.|:..|:..:..|:||.|.|.:..:...|.|
  Rat    75 SKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRH 139

  Fly   491 MA---------------QRHDEHGFI-------------------YECKRCQRTFLTQQRLQRHQ 521
            :|               |..:..|.:                   ::|:.|:|.|.|::.::||.
  Rat   140 LALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHM 204

  Fly   522 AVG-------CQ------------------RHKEDSVRIKEEQSRF 542
            .|.       ||                  .|.::.:::|.|...|
  Rat   205 VVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDF 250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12391NP_610639.1 zf-AD 240..313 CDD:285071
zf-C2H2 416..438 CDD:278523 6/23 (26%)
C2H2 Zn finger 418..438 CDD:275368 6/21 (29%)
zf-C2H2 443..465 CDD:278523 7/21 (33%)
C2H2 Zn finger 445..465 CDD:275368 6/19 (32%)
C2H2 Zn finger 474..491 CDD:275368 5/16 (31%)
C2H2 Zn finger 504..521 CDD:275368 6/16 (38%)
Plag1NP_001008317.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 7/22 (32%)
Interaction with KPNA2. /evidence=ECO:0000250 2..84 20/73 (27%)
Nuclear localization signal. /evidence=ECO:0000250 22..25 1/2 (50%)
C2H2 Zn finger 36..56 CDD:275368 4/19 (21%)
Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250 41..242 42/200 (21%)
SFP1 <58..139 CDD:227516 23/80 (29%)
C2H2 Zn finger 64..86 CDD:275368 6/21 (29%)
zf-H2C2_2 79..103 CDD:404364 8/23 (35%)
C2H2 Zn finger 94..114 CDD:275368 6/19 (32%)
C2H2 Zn finger 123..143 CDD:275368 7/19 (37%)
C2H2 Zn finger 152..172 CDD:275368 2/19 (11%)
C2H2 Zn finger 187..207 CDD:275368 7/19 (37%)
C2H2 Zn finger 215..233 CDD:275368 2/17 (12%)
Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250 243..499 3/8 (38%)
Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250 243..383 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..400
Massively activates transcription. /evidence=ECO:0000250 384..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166350870
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.