DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12391 and Zfp711

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001368827.1	Gene:	Zfp711 / 245595	MGIID:	3045342	Length:	805	Species:	Mus musculus

Alignment Length:	709	Identity:	145/709 - (20%)
Similarity:	225/709 - (31%)	Gaps:	269/709 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEADIT---PLAETNGEQRQNPQESAQNQEQPQPRQDLAGKSVGSADDGVSGTVGQIMDYLEDDA 62
            :|||:.   .|.|.:|:.....:...:....|:        .|..| |.|||..|. ::::..|.
Mouse    94 LEADVAIEEDLEEDDGDHILTSELITETVRVPE--------QVFVA-DLVSGPDGH-LEHVVQDC 148

  Fly    63 GATADQDAEMGEAEYLDGEMPQEDESETPQTEKANEGCQESSNKKDLQESAAKDDFSKEKSGED- 126
            .:..|....:.|...:       ..|:|....:|..|...|:.....:|.   ||...:.:.||
Mouse   149 VSGVDSPTMVSEEVLV-------TNSDTETVIQAGGGVPGSTVTIKTEED---DDDDVKSTSEDY 203

  Fly   127 --------GEK-----DTDKEKKATHLHEDNNDDAEKDGDEA------DAEDEDDVEKPEDEDGT 172
                    |||     :|..:..:....||..:||  .|.|.      .||.|||||....|..|
Mouse   204 LMISLDDVGEKLEHMGNTPLKIASDGSQEDVKEDA--FGSEVIKVYIFKAEAEDDVEIGGTEIVT 266

  Fly   173 EEGDEAIEEDEDALDED------------EDPNEEVEEIEPDFETGTDAEGEL----ITGDEPGD 221
            |....:.......||:.            :|.::|.::|     :..|...||    |.|:|.|.
Mouse   267 ESEYSSGHSVAGVLDQSRMQREKMVYMAVKDSSQEQDDI-----SNADISNELCMEVIIGEEEGT 326

  Fly   222 LADVPIRE---RKKEEPV----DEDQCRVCTSKEELVC-----LFKKQID--ATPADMLLVICPN 272
            ..::|:::   .|...||    ..|:.||....||  |     .|...::  .|.|...|.||.:
Mouse   327 PLEIPLQDCDVNKTGSPVLSPASYDERRVSRRYEE--CQAPGNTFDSALENRNTTAAQYLQICDS 389

  Fly   273 VSILPKDFMPQFICTKCMGSLTIAIQLRKQLETTDQELRKRL-SRSKNKVRRPRGYVVIDAPVTD 336
            ::                               |::.|:::: .|.:.:.|:.:..|:|
Mouse   390 MN-------------------------------TNKVLKQKIKKRRRGETRQWQTAVII------ 417

  Fly   337 SSEDEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGRP---------RKKPLKRG-- 390
                                                    ||.|:|         .||...||
Mouse   418 ----------------------------------------GPDGQPLTVYPCHICTKKFKSRGFL 442

  Fly   391 -TDSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQSYVLH----------RKTHERIE-- 442
             ......|....:||||           |.:||.|.::|.|:..|          .||||..|
Mouse   443 KRHMKNHPDHLMRKKYQ-----------CTDCDFTTNKKVSFHNHLESHKLINKVDKTHEFTEYT 496

  Fly   443 ----------------------------------------------------HACPICGKKFKVE 455
                                                                |.|..|||.|:..
Mouse   497 RRYREASPLSSNKLILRDKEPKMHKCKYCDYETAEQGLLNRHLLAVHSKSFPHVCVECGKGFRHP 561

  Fly   456 WAYKTHMQRHEQERAHFRCELCPKIFRL--RAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQ 518
            ...|.||:.|..|:. ::|:.|  .||.  ::.||.|:..:|..: ..|:|:.|.:.|..::.||
Mouse   562 SELKKHMRTHTGEKP-YQCQYC--AFRCADQSNLKTHIKSKHGSN-LPYKCEHCPQAFGDERELQ 622

  Fly   519 R----------HQAVGCQRHKEDSVRIKEEQSRFKQESRSKDDRHHGNNSSK--RRPGE 565
            |          ||...|.....:|..:|    |......:||..|......|  .||.|
Mouse   623 RHLDLFQGHKTHQCPHCDHKSTNSSDLK----RHIISVHTKDFPHKCEVCDKGFHRPSE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	13/79 (16%)
		zf-C2H2	416..438	CDD:278523	8/31 (26%)
		C2H2 Zn finger	418..438	CDD:275368	8/29 (28%)
		zf-C2H2	443..465	CDD:278523	9/21 (43%)
		C2H2 Zn finger	445..465	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..491	CDD:275368	6/18 (33%)
		C2H2 Zn finger	504..521	CDD:275368	6/26 (23%)
Zfp711	NP_001368827.1	Zfx_Zfy_act	65..412	CDD:398398	79/377 (21%)
		COG5048	425..805	CDD:227381	60/272 (22%)
		C2H2 Zn finger	429..449	CDD:275368	4/19 (21%)
		C2H2 Zn finger	522..543	CDD:275368	0/20 (0%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
		C2H2 Zn finger	579..600	CDD:275368	7/22 (32%)
		C2H2 Zn finger	608..634	CDD:275368	6/25 (24%)
		C2H2 Zn finger	636..657	CDD:275368	4/24 (17%)
		C2H2 Zn finger	665..685	CDD:275368	4/13 (31%)
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100