DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and Zfp641

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_776130.1	Gene:	Zfp641 / 239652	MGIID:	2442788	Length:	422	Species:	Mus musculus

Alignment Length:	384	Identity:	84/384 - (21%)
Similarity:	124/384 - (32%)	Gaps:	120/384 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 EDPNEEVEEIEPDFETGTDAEGELITGDEPGD-----LADVP--IRERKKEEP------------ 235
            |..|.:::..|...|.||..||...|...|.:     |.|.|  ::|:....|
Mouse    14 EPMNTQLDAAELQSERGTREEGSWRTAPRPLEHLHCGLEDEPLSLQEKATSVPWVPAVPQEGNTG 78

  Fly   236 ----------------VDEDQCRVCTSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMPQF 284
                            |......:|.|:||...|...|                    .||..::
Mouse    79 DWEMAAALLAAGSQGLVTIKDVSLCFSQEEWRSLDPSQ--------------------TDFYGEY 123

  Fly   285 ICTKCMGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFK 349
            :..:..|   |.:.||..:...|.     ||:.                  :..||:...|.:
Mouse   124 VMQENCG---IVVSLRFPIPKLDM-----LSQQ------------------EGGEDQWAPDPQ-- 160

  Fly   350 VSDVAG------TTSADSDSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSDGEPSSAQKKKYQPS 408
              ||.|      |.:.|......|..|.:.:.|        :.|...|:.....:..|...::..
Mouse   161 --DVEGRDILKVTYTGDGGEPQGDTPELQVEPP--------RTLSSVTEDTALWNPGQGPSWESM 215

  Fly   409 STASVGPFECPNC--DLTFSRKQSYVLHRKTHERI--EHACPICGKKFKVEWAYKTHMQRHEQ-- 467
            ...|.|....|..  :.||||.    |||...:.:  .|.||.|||:|    .:.:|:.||:|
Mouse   216 PRNSTGMLLSPRFLQEDTFSRH----LHRTDTDSLLKPHTCPQCGKQF----VWGSHLARHQQTH 272

  Fly   468 --ERAHFRCELCPKIFRLRAEL-KHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAV 523
              ||. :.|..|.|.|..|..| :|.....||:..   .|..|.::|.....|..||.|
Mouse   273 TGERP-YSCLKCEKSFGRRHHLIRHQKTHLHDKPS---RCSECGKSFRCSSHLASHQRV 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	13/72 (18%)
		zf-C2H2	416..438	CDD:278523	8/23 (35%)
		C2H2 Zn finger	418..438	CDD:275368	8/21 (38%)
		zf-C2H2	443..465	CDD:278523	8/21 (38%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..491	CDD:275368	7/17 (41%)
		C2H2 Zn finger	504..521	CDD:275368	4/16 (25%)
Zfp641	NP_776130.1	PLN03206	<2..90	CDD:178745	15/75 (20%)
		KRAB	95..155	CDD:214630	18/105 (17%)
		Transactivation. /evidence=ECO:0000250	157..251		22/109 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..191		3/18 (17%)
		COG5048	<237..407	CDD:227381	32/103 (31%)
		C2H2 Zn finger	252..272	CDD:275368	10/23 (43%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	7/20 (35%)
		C2H2 Zn finger	358..378	CDD:275368
		C2H2 Zn finger	386..406	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930