DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12391 and Zkscan2

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001074798.1	Gene:	Zkscan2 / 210162	MGIID:	2444060	Length:	960	Species:	Mus musculus

Alignment Length:	709	Identity:	135/709 - (19%)
Similarity:	221/709 - (31%)	Gaps:	253/709 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GEQRQNPQESAQNQEQPQPRQDLAGKSVGSADDGVSGTVGQIMDYLED-----------DAGATA 66
            |:....|.:.||.:::.:|      .|||........:|.| .:|:::           :||...
Mouse   262 GDSVSAPNKIAQLEQKKEP------WSVGLHSSNKRNSVLQ-SNYIKEKSVHAVQIPARNAGKVW 319

  Fly    67 DQDAEMG-EAEYLDGEMPQEDESET-----------------PQTE----------------KAN 97
            .:..:.| |.|.:.|.....:|::|                 |:..                :..
Mouse   320 REQQQWGLEDEKIAGVHWSYEETKTFLAILKESRFYETLQACPRNSQVYGAVAEWLRECGFLRTP 384

  Fly    98 EGCQESSNKKDLQESAAKDDFSKEKSG---------EDGE---------KDTDKEKKATHLHEDN 144
            |.|:  :..|.||:|     :.|.::|         ||.:         ..|::.|....|....
Mouse   385 EQCR--TKFKSLQKS-----YRKVRNGHMLEPCAFFEDMDALLNPAAHTSSTERPKVVISLPLKR 442

  Fly   145 NDDAEKDGDEADAEDEDDVEKPEDEDGTEEGDEAIEEDE-------------------------D 184
            ...:.|  ::....:|:  |..||.||.|.|.|.|.:.|                         |
Mouse   443 TAISAK--EQVSLVEEE--EGAEDSDGDEVGIEFIRKSEIRAAPVLFQNLSGVHWGYEETKTFLD 503

  Fly   185 ALDEDEDPNEEVEEIEPDFET----GTDAE-----GELITGDEPGDLADVPIRERKKEEPVDEDQ 240
            .|.|    ....|.::.....    |..||     |.|.|          |.:.|.|.:.:.:..
Mouse   504 ILQE----TRFYEALQACHRKSKLYGVVAEQLRECGFLRT----------PEQCRTKFKSLQKSY 554

  Fly   241 CRVCTSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMPQFICTKCMGSLTIAIQLRKQLET 305
            .:|........|.|.|::||      ||.|...|                            |.|
Mouse   555 RKVKNGHVLESCAFYKEMDA------LVNCRPSS----------------------------LST 585

  Fly   306 TDQELRKRLSRSKN-----KVRRPRGYVVIDAP----VTDSSED---EDELDDEFKVSDVAGTTS 358
            ...|....|||.:.     :.|.|..:..::.|    :.||..:   |:|:.:|.::...:|...
Mouse   586 NTSEEVPSLSRQERGHIEVEPREPTTWEPVETPQEAVLEDSGSERLSEEEMIEEPELEGPSGLLQ 650

  Fly   359 ADS-----DSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSDGEPSSAQKKKY------------- 405
            :.:     .....|.::...|...|.....:|| ||....:..||...|::|
Mouse   651 SPAGFEIGTIIKEDPTQVMFKDTEPHRVLMEKP-KRLVSQNTNPSKYCKREYFSGRHCENLQGVR 714

  Fly   406 ------QPSSTAS--------VG-----------------------------PFECPNCDLTFSR 427
                  ||..|..        ||                             ||:|..|...|.|
Mouse   715 QGKLMSQPRDTGKAVVHQRPCVGRRPYRLLKYGENFGRSARLVCRMTHQKENPFKCGVCGKCFGR 779

  Fly   428 KQSYVLHRKTH--ERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAELKHH 490
            .:|.:.|::.|  |: ...||.|||.|.....:..|.:.|..|:. :||..|.|.|...:.|..|
Mouse   780 SRSLIRHQRIHTGEK-PFKCPDCGKSFNDSSNFGAHQRVHTGEKP-YRCRECGKCFSQSSSLIIH 842

  Fly   491 MAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAV----------GCQRHKEDSVRIKEEQ 539
            ......|..  |:|:.|.::|........|:.:          .|::...:..|.:|.|
Mouse   843 QRTHTGEKP--YQCEECGKSFTNSSHFSAHRRIHTEENPYKCGDCEKSFNNCARFREHQ 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	13/72 (18%)
		zf-C2H2	416..438	CDD:278523	7/21 (33%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	7/21 (33%)
		C2H2 Zn finger	445..465	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	3/16 (19%)
Zkscan2	NP_001074798.1	SCAN	42..148	CDD:128708
		SCAN	42..129	CDD:280241
		KRAB	<241..282	CDD:214630	5/25 (20%)
		Myb_DNA-bind_4	334..415	CDD:290549	12/87 (14%)
		ABC_trans_N	<466..505	CDD:291196	6/38 (16%)
		Myb_DNA-bind_4	490..571	CDD:290549	16/94 (17%)
		COG5048	<766..915	CDD:227381	36/138 (26%)
		zf-C2H2	768..790	CDD:278523	7/21 (33%)
		C2H2 Zn finger	770..790	CDD:275368	6/19 (32%)
		zf-H2C2_2	782..806	CDD:290200	9/24 (38%)
		C2H2 Zn finger	798..818	CDD:275368	7/19 (37%)
		zf-H2C2_2	814..835	CDD:290200	8/21 (38%)
		C2H2 Zn finger	826..846	CDD:275368	6/19 (32%)
		zf-H2C2_2	838..863	CDD:290200	7/26 (27%)
		C2H2 Zn finger	854..874	CDD:275368	4/19 (21%)
		zf-H2C2_2	866..891	CDD:290200	2/24 (8%)
		C2H2 Zn finger	882..902	CDD:275368	4/18 (22%)
		zf-H2C2_2	895..918	CDD:290200	2/5 (40%)
		C2H2 Zn finger	910..930	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930