DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZNF573

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001166161.1	Gene:	ZNF573 / 126231	HGNCID:	26420	Length:	665	Species:	Homo sapiens

Alignment Length:	110	Identity:	36/110 - (32%)
Similarity:	51/110 - (46%)	Gaps:	6/110 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 FECPNCDLTFSRKQSYVLHRKTH--ERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCP 478
            |||..|...:|...:.:.|||||  |: .:.|..|||.|.:......|.:.|...:. :.|::|.
Human   470 FECQECGKAYSTGSNLIQHRKTHTGEK-PYKCKECGKTFSLHGYLNQHQKIHTGMKP-YECKVCR 532

  Fly   479 KIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQAV 523
            |.|.....|..|.:...||..|  |||.|.:||.....|..||::
Human   533 KTFTFYRNLTLHQSIHTDEKPF--ECKECGKTFRRSSHLTAHQSI 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071
		zf-C2H2	416..438	CDD:278523	8/21 (38%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-C2H2	443..465	CDD:278523	6/21 (29%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	6/16 (38%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630
		KRAB	28..67	CDD:279668
		C2H2 Zn finger	136..156	CDD:275368
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	192..212	CDD:275368
		C2H2 Zn finger	220..240	CDD:275368
		COG5048	244..628	CDD:227381	36/110 (33%)
		C2H2 Zn finger	248..268	CDD:275368
		zf-H2C2_2	260..285	CDD:290200
		C2H2 Zn finger	276..292	CDD:275368
		C2H2 Zn finger	304..324	CDD:275368
		C2H2 Zn finger	332..352	CDD:275368
		C2H2 Zn finger	360..380	CDD:275368
		C2H2 Zn finger	388..408	CDD:275368
		zf-H2C2_2	401..424	CDD:290200
		C2H2 Zn finger	416..436	CDD:275368
		C2H2 Zn finger	444..464	CDD:275368
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	10/24 (42%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		zf-H2C2_2	512..536	CDD:290200	5/24 (21%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		C2H2 Zn finger	556..576	CDD:275368	8/20 (40%)
		C2H2 Zn finger	584..604	CDD:275368
		zf-H2C2_2	596..621	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000