DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12391 and ZNF813

DIOPT Version :9

Sequence 1:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	494	Identity:	106/494 - (21%)
Similarity:	164/494 - (33%)	Gaps:	147/494 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DQDAEMGEAEYLDGEMPQEDE---SETPQTEKANEGCQESSNKKDLQESAAKDDFSKEKSGEDGE 128
            |:|....|.::      ||||   .|.|.||           .|.|..||  |.:.:..:|....
Human    91 DKDIHNLEFQW------QEDERNSHEAPMTE-----------IKKLTGSA--DRYDQRHAGNKPI 136

  Fly   129 KDTDKEKKATHLHEDNNDDAE-KDGDEADAEDEDDVE---------KPEDEDGTEEGDEAIEEDE 183
            ||.......:||.|.:....: |.|::.:....|...         :|:.......|:..  .:.
Human   137 KDQLGSSFHSHLPELHMFQTQGKIGNQVEKSINDASSISTSQRISCRPKTHISNNYGNNF--RNS 199

  Fly   184 DALDEDEDPNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKE-EPVDEDQ--CRVC- 244
            ..|.:    .:||...|..|:.           :|.|...:.....||.: ..:.|.|  |.||
Human   200 SLLTQ----KQEVHMREKSFQC-----------NESGKAFNYSSLLRKHQIIHLGEKQYKCDVCG 249

  Fly   245 ---TSKEELVCLFKKQIDATPADMLLVICPNVSILPKDFMPQFICTKC--MGSLTIAIQLRKQLE 304
               ..|..|||..:......|                     :.|.:|  ..|.|.::...::|.
Human   250 KVFNRKRNLVCHRRCHTGEKP---------------------YRCNECGKTFSQTYSLTCHRRLH 293

  Fly   305 TTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDEDELDDEFKVSDVAGTTSADSDSADSDDS 369
            |.::..:.                             :|.|..|                    |
Human   294 TGEKPYKC-----------------------------EECDKAF--------------------S 309

  Fly   370 EKEKKKPGPRGRPRKKPLKRG----TDSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQS 430
            .|...|...|....:||.|..    |.|.....:..::.:....     ||:|..|..|||||.|
Human   310 FKSNLKRHRRIHAGEKPYKCNECGKTFSQTSSLTCHRRLHTGEK-----PFKCNECGKTFSRKSS 369

  Fly   431 YVLHRKTH--ERIEHACPICGKKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAEL-KHHMA 492
            ...|.:.|  |: .:.|..|||.|..|...|.|.:.|..|:. ::|..|.|:|..:|.| :||..
Human   370 LTCHHRLHTGEK-PYKCNECGKTFSQELTLKCHRRLHTGEKP-YKCNECGKVFNKKANLARHHRL 432

  Fly   493 QRHDEHGFIYECKRCQRTFLTQQRLQRHQA--VGCQRHK 529
            ...::.   |:|..|.:||.....|..|:|  :|.:|:|
Human   433 HSGEKP---YKCTECVKTFSRNSALVIHKAIHIGEKRYK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	15/80 (19%)
		zf-C2H2	416..438	CDD:278523	10/21 (48%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		zf-C2H2	443..465	CDD:278523	8/21 (38%)
		C2H2 Zn finger	445..465	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..491	CDD:275368	7/17 (41%)
		C2H2 Zn finger	504..521	CDD:275368	5/16 (31%)
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	80/375 (21%)
		C2H2 Zn finger	217..237	CDD:275368	4/30 (13%)
		zf-H2C2_2	230..254	CDD:290200	7/23 (30%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	6/45 (13%)
		C2H2 Zn finger	273..293	CDD:275368	4/19 (21%)
		zf-H2C2_2	285..309	CDD:290200	5/72 (7%)
		C2H2 Zn finger	301..321	CDD:275368	7/68 (10%)
		zf-H2C2_2	313..338	CDD:290200	6/24 (25%)
		C2H2 Zn finger	329..349	CDD:275368	2/19 (11%)
		zf-H2C2_2	341..366	CDD:290200	6/29 (21%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	9/25 (36%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	398..421	CDD:290200	7/23 (30%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..489	CDD:275368	106/494 (21%)
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:290200
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	553..573	CDD:275368
		zf-H2C2_2	565..590	CDD:290200
		C2H2 Zn finger	581..601	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000