DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12391 and ZNF274

DIOPT Version :9

Sequence 1:NP_610639.1 Gene:CG12391 / 36170 FlyBaseID:FBgn0033581 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_598009.1 Gene:ZNF274 / 10782 HGNCID:13068 Length:653 Species:Homo sapiens


Alignment Length:573 Identity:112/573 - (19%)
Similarity:166/573 - (28%) Gaps:242/573 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 VEKPEDEDGTEEG---DEAIEEDEDALDEDEDP--------NEEVEEI----------------- 199
            :|:.||....|.|   |...|..|..||...||        |.||.|:                 
Human    66 LEEAEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQIQA 130

  Fly   200 --EPDFETGTDAEGELI--TGDEPGD--------------------------------------- 221
              ..|.....||..|.:  .|..|||                                       
Human   131 LYAEDGSLSADAPSEQVQQQGKHPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKAR 195

  Fly   222 --------------LADVPIRERKKEEPVDEDQCR---------VCTSKEELV-----------C 252
                          |..:|::.|...|....:.|:         ...|:||::           |
Human   196 SKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCC 260

  Fly   253 L------FKKQIDATPADMLLVICPNVSILPK----------DFMPQ--------------FICT 287
            |      .:||.||       .||| |::||:          ||..:              .:..
Human   261 LEVTAQQEEKQEDA-------AICP-VTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVML 317

  Fly   288 KCMGSLTIAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAP-----VTDSSED---EDEL 344
            :..|.| :::.....||              ||...|...:..:.|     |.:||.|   ...|
Human   318 ETFGHL-VSVGWETTLE--------------NKELAPNSDIPEEEPAPSLKVQESSRDCALSSTL 367

  Fly   345 DDEFK--VSDVAGTTSADSDSADSDDSEKEK----------------------KKPGPRGR---- 381
            :|..:  |.:|..|.....:||...|..::|                      |...|..:    
Human   368 EDTLQGGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTNQVSLQKIDNPESQANSG 432

  Fly   382 -------------PRKKPLKRGTDSDGEPSSAQKKKYQPS------------------STASVGP 415
                         |||:..||.:.......:::.|.:|.|                  ||..: .
Human   433 ALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQI-T 496

  Fly   416 F----------ECPNCDLTFSRKQSYVLHRKTH--ERIEHACPICGKKFKVEWAYKTHMQRHEQE 468
            |          .|..|...|...:.:.:|:|.|  || .:.|..|||.|....:...|.:.|..|
Human   497 FIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGER-PYVCQDCGKGFVQSSSLTQHQRVHSGE 560

  Fly   469 RAHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRLQRHQ 521
            |. |.|:.|.:.|..|:.:..|:  |.......|:|:.|.:.|.....|.|||
Human   561 RP-FECQECGRTFNDRSAISQHL--RTHTGAKPYKCQDCGKAFRQSSHLIRHQ 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12391NP_610639.1 zf-AD 240..313 CDD:285071 22/122 (18%)
zf-C2H2 416..438 CDD:278523 6/31 (19%)
C2H2 Zn finger 418..438 CDD:275368 5/19 (26%)
zf-C2H2 443..465 CDD:278523 6/21 (29%)
C2H2 Zn finger 445..465 CDD:275368 6/19 (32%)
C2H2 Zn finger 474..491 CDD:275368 4/16 (25%)
C2H2 Zn finger 504..521 CDD:275368 5/16 (31%)
ZNF274NP_598009.1 KRAB 14..73 CDD:214630 3/6 (50%)
KRAB 14..53 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..159 7/19 (37%)
SCAN 157..269 CDD:128708 10/111 (9%)
SCAN 157..245 CDD:280241 6/87 (7%)
KRAB 287..>327 CDD:214630 4/40 (10%)
KRAB 287..326 CDD:279668 4/39 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..359 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 4/25 (16%)
COG5048 <389..644 CDD:227381 48/227 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..485 6/36 (17%)
C2H2 Zn finger 481..501 CDD:275368 3/20 (15%)
C2H2 Zn finger 509..529 CDD:275368 5/19 (26%)
zf-H2C2_2 521..546 CDD:290200 10/25 (40%)
C2H2 Zn finger 537..557 CDD:275368 6/19 (32%)
zf-H2C2_2 549..573 CDD:290200 7/24 (29%)
zf-C2H2 563..585 CDD:278523 7/23 (30%)
C2H2 Zn finger 565..585 CDD:275368 6/21 (29%)
zf-C2H2 591..613 CDD:278523 8/20 (40%)
C2H2 Zn finger 593..613 CDD:275368 7/18 (39%)
zf-H2C2_2 605..630 CDD:290200 4/6 (67%)
C2H2 Zn finger 621..641 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..653
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156922
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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