DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rps6kb2 and S6k

DIOPT Version :9

Sequence 1:	NP_001010962.2	Gene:	Rps6kb2 / 361696	RGDID:	1305144	Length:	485	Species:	Rattus norvegicus
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	286/481 - (59%)
Similarity:	340/481 - (70%)	Gaps:	27/481 - (5%)

- Green bases have known domain annotations that are detailed below.

  Rat     6 DLDLETEEGSEGEGEP-EFNPADVCPLGELRAAGL--ETVGHYEEVELTESSVNLGPERIGPHCF 67
            ||:|:.::..:.:.:. |.:..|:.|  || ...|  :|.|. |.::|.|.:||.|..::||..|
  Fly    17 DLELQDDKARDSDDDRIELDDVDLEP--EL-CINLHQDTEGQ-ETIQLCEENVNPGKIKLGPKDF 77

  Rat    68 ELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIV 132
            ||..|||||||||||||||..|.:..|.:|||||:||.||.:.||||||||||||||:|||||||
  Fly    78 ELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIV 142

  Rat   133 ELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKP 197
            ||.|||||.||||||||.|||||||.||||||||||||.||||:||.|||||||..|||||||||
  Fly   143 ELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKP 207

  Rat   198 ENIMLNSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRIGHNRAVDWWSLGALMYDM 262
            |||:|::|||:||||||||||.|.||.:||||||||||||||||.|.||.:|||||||||||:||
  Fly   208 ENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDM 272

  Rat   263 LTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTHRIGGGPGDAADVQRHPF 327
            |||.|||||||||||::.|:|.||.||.||||:||||.::.:||....|:|.||.|||.||.|||
  Fly   273 LTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPF 337

  Rat   328 FRHINWDDLLAHRVDPPFRPSLQSEEDVSQFDVRFTRQTPVDSPDDTALSESANQAFLGFTYVAP 392
            |:|:||||:||.|::||.:|.|:||:||||||.|||||.||||||||.||||||..|.|||||||
  Fly   338 FKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAP 402

  Rat   393 SVLDSIKEGFSFQPKLRSPRR----------------LNSSPRTPISPLKFSPFEGFRPSPGPPE 441
            |:|:.:..  :.:...|||||                .|.....|::....|...|......||.
  Fly   403 SILEDMHR--ANRMPARSPRRTPRQLPDSSFRLQFPSANVGANAPLAMHGHSQRSGMFARATPPH 465

  Rat   442 PMEPSLPPLLPPPSSPPPTSTAPLPI 467
            .|:...|  .|.|:.........||:
  Fly   466 HMQTFAP--RPSPAQDEMMDVQGLPM 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rps6kb2	NP_001010962.2	STKc_p70S6K	70..392	CDD:270736	243/321 (76%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	241/320 (75%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	243/320 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334265
Domainoid	1	1.000	427	1.000	Domainoid score	I584
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1078
OMA	1	1.010	-	-		QHG51952
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		otm46215
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24351
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770