DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13229 and dmsr-5

DIOPT Version :9

Sequence 1:	NP_001260880.1	Gene:	CG13229 / 36168	FlyBaseID:	FBgn0033579	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_499413.1	Gene:	dmsr-5 / 190009	WormBaseID:	WBGene00012962	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	103/358 - (28%)
Similarity:	176/358 - (49%)	Gaps:	39/358 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 RAYNSIHGYVSLMICIFGTIANILNIMVLTRKEMAKTPINNILKWLAVADMFVMLEYIPYTSYQY 134
            :.|..:|.|:.|.:|.||.:.|.|:..|||||.|....||.:|..:::.|:..|..|..|.....
Worm    28 QVYTVLHRYLCLFVCFFGVLLNSLHFYVLTRKAMRVYIINALLCAMSICDIITMTSYFIYILRFR 92

  Fly   135 IYMGPGE-KDLSYTWAVCLLVHMHFTQILHTISIGLTVTLAVWRYVAIRHPNGGCANFLLAHS-- 196
            |:..|.. ...||.|.:.|:.|:..:..|||.|:.|:|.:|..|:.|:...:....|    |.
Worm    93 IFDTPSTIIGYSYPWLIFLITHVTSSIALHTTSLYLSVIMAYIRWTALDRLDAKWIN----HGAL 153

  Fly   197 REAILLPFILSPILCLPTYFVFQV---------RETYDVDKVNSEAMYHVYFDKDSV----LYRF 248
            ::.::...::..::.:||..|.::         .||..::....:.:|.|..|:..:    |:|.
Worm   154 KQILIFTALIVSVISIPTVMVHKIVPVTEVLGMNETDLLEGAKFDGLYTVQLDETKINGCALFRV 218

  Fly   249 NFWIHSVLIKLLPCGILIVISAVLMHVLCEASRRRLKLRDYNNPAKYAIQLNL--------NETK 305
            |.||..::.|.|||.:::..:..|::.|.:.|.:|..||   ...:..::..|        ..|:
Worm   219 NLWITGIMFKALPCLLILWFTIALIYKLVQMSEKRKILR---GEKRENVEFQLLATSATPTTTTR 280

  Fly   306 SKKPPR------CDRR--NDRTTLLLVAVLVLFLITEFPQGLLGLLSGVMEKCFFAHCYPPFGEL 362
            ::..||      |.|.  .|||||:|:.:||:||.||.|||||.:||.:.........|...||:
Worm   281 NEASPRLRKVSQCSRNVSIDRTTLMLIIMLVVFLCTEMPQGLLSILSAIYPTHVHTMIYVNVGEV 345

  Fly   363 MDLLALINAAVGFVLYGLMSKQFRTTFRSLFMK 395
            :||::|||....|::|.:||..:|.|.:|:..:
Worm   346 LDLMSLINCLTSFIVYCVMSTTYRATVKSVLCR 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13229	NP_001260880.1	7tm_4	78..393	CDD:304433	101/346 (29%)
dmsr-5	NP_499413.1	7tmA_FMRFamide_R-like	32..372	CDD:320109	100/346 (29%)
		TM helix 1	34..58	CDD:320109	10/23 (43%)
		TM helix 2	67..89	CDD:320109	6/21 (29%)
		TM helix 3	112..134	CDD:320109	7/21 (33%)
		TM helix 4	155..171	CDD:320109	0/15 (0%)
		TM helix 5	217..240	CDD:320109	8/22 (36%)
		TM helix 6	300..325	CDD:320109	17/24 (71%)
		TM helix 7	340..365	CDD:320109	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12281
OMA	1	1.010	-	-		QHG28978
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46273
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.930