DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13229 and dmsr-2

DIOPT Version :9

Sequence 1:	NP_001260880.1	Gene:	CG13229 / 36168	FlyBaseID:	FBgn0033579	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_490992.2	Gene:	dmsr-2 / 189527	WormBaseID:	WBGene00021275	Length:	407	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	103/376 - (27%)
Similarity:	174/376 - (46%)	Gaps:	70/376 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TPQVDECQGYCQGEIYNWLRAYNSIHGYVSLMICIFGTIANILNIMVLTRKEMAKTPINNILKWL 115
            |.::.|.:.|.:..:..:..::...|.|:.:.:|:.|..|||..::||.|..|.|:|.|..|..:
Worm     8 TTELQEARDYFRQLLLPFTASFTMFHNYIYVFLCVIGVFANISIVVVLLRPAMRKSPFNLFLVVI 72

  Fly   116 AVADMFVMLEYIPYTSYQYIYMGPGEKDLSYTWAVCLLVHMHFTQILHTISIGLTVTLAVWRYVA 180
            ||.|..:|..|:.|...:..:  |..  .|:.||:....:..|:..:|:.|:.|||.:|:.|::.
Worm    73 AVCDASLMATYLTYKHVELCH--PWY--FSFPWAIYTKFYAIFSVFVHSCSLWLTVNMAILRFLV 133

  Fly   181 I--------RHP--NGGCANFLLAHSREAILLPFILSPILCLPTYFVFQV--RETYDVDKVNSEA 233
            :        |.|  ||..|.|:      ||:|.|.::.|.|||.:..:::  .|...|..:..|.
Worm   134 LYRGSRSETRIPQCNGFGAAFV------AIVLAFAIACIGCLPIFIRYRIIEGEVGAVPDLCLEG 192

  Fly   234 MYHVYFDKDSVLY---------------RFNFWIHSVLIKLLPCGILIVISAVLMHVLCEASRRR 283
            .|...:..:.::.               |.|:|:.::::||:||.:|.:...:|:.:|.||..||
Worm   193 KYSTDWQPNDMIQFYGLSQPLWWNCDWERINYWMAALILKLIPCLLLTIFMTLLVRMLIEARERR 257

  Fly   284 LKLRDYNNPAKYAIQLNLNETKSKKPPRC------DRRNDRTTLLLVAVLVLFLITEFPQGLLGL 342
            .:|                         |      :.:.:|||.:|..::.:|||||.|||:|..
Worm   258 SRL-------------------------CGGMGNGNSQAERTTAMLTGIVAIFLITELPQGVLTF 297

  Fly   343 LSGVMEKCFFAHCYPPFGELMDLLALINAAVGFVLYGLMSKQFRTTFRSLF 393
            .:|...:..|...  ....:.|||:|||:||.|||..|||..||..|...|
Worm   298 AAGANPRLTFLTL--QMNNVFDLLSLINSAVNFVLCALMSHVFRREFLQTF 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13229	NP_001260880.1	7tm_4	78..393	CDD:304433	98/347 (28%)
dmsr-2	NP_490992.2	7tmA_FMRFamide_R-like	32..342	CDD:320109	98/346 (28%)
		TM helix 1	33..57	CDD:320109	9/23 (39%)
		TM helix 2	66..92	CDD:320109	8/25 (32%)
		TM helix 3	106..128	CDD:320109	6/21 (29%)
		TM helix 4	155..171	CDD:320109	7/21 (33%)
		TM helix 5	221..244	CDD:320109	8/22 (36%)
		TM helix 6	273..297	CDD:320109	13/23 (57%)
		TM helix 7	311..335	CDD:320109	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46273
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.980