DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13229 and dmsr-14

DIOPT Version :9

Sequence 1:	NP_001260880.1	Gene:	CG13229 / 36168	FlyBaseID:	FBgn0033579	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001309648.1	Gene:	dmsr-14 / 188521	WormBaseID:	WBGene00020523	Length:	353	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	81/352 - (23%)
Similarity:	153/352 - (43%)	Gaps:	79/352 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YNSIHGYVSLMICIFGTIANILNIMVLTRKEMAKTPINNILKWLAVADM-----FVMLEYIPYTS 131
            |...|.|:...:.:|...||||.::||:.|||..:.||.|:.::||:|.     .:|..:|...|
Worm    38 YRPYHYYLLSSLIVFSFFANILIVIVLSHKEMRHSGINVIMMFIAVSDFGCAVTGLMQLFIRNYS 102

  Fly   132 YQYIYMGPGEKDLSYTWAVCLLVHMHFTQILHTISIGLTVTLAVWRYVAIRHPNG---------- 186
            .||:        |..|..:.|.|. :...:.|..|:.|...:|:.|.:|:...|.
Worm   103 DQYM--------LFITAYLQLFVD-YLAVVFHASSLFLAAGMALCRVMALNFSNRLKDKWQSPRY 158

  Fly   187 ----GCANFLLAHSREAILLPFILSPILCLPTYFVFQVRETYDVDKVNSEAMYHVYFDKDSVLYR 247
                .||.::...:...:::|             |.:|::|.|.:         ||.|.......
Worm   159 ALRVTCAVYITVLTVSTLIVP-------------VNEVKKTDDGE---------VYIDTSDFSLA 201

  Fly   248 FNFWIHSVLI-------KLLPCGILIVISAVLMHVLCEASRRRLKLRDYNNPAKYAIQLNLNETK 305
            :...:..:::       ||:||.:::::|.:|:..:.|..|.             ::.:|.|..|
Worm   202 YGCLLMKIVLVFVGICFKLIPCTLMLILSILLLQKMDEGKRS-------------SVPINRNHKK 253

  Fly   306 SKKPPRCDRRNDRTTLLLVAVLVLFLITEFPQGLLGLLSGVMEKCFFAHCYPPFGELMDLLALIN 370
            .:.        ||::.|:..:|::|||||.|||:..::.|: |...:.:.|......|::|:..|
Worm   254 DQL--------DRSSQLIQTILIVFLITEVPQGVFSIIGGI-EVIDYLNYYQNLTIFMNVLSFFN 309

  Fly   371 AAVGFVLYGLMSKQFRTTFRSLFMKRH 397
            ....|::|..:|.:||..|...|:.::
Worm   310 TTTSFIIYSSLSAKFRRIFAQTFLPKN 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13229	NP_001260880.1	7tm_4	78..393	CDD:304433	78/340 (23%)
dmsr-14	NP_001309648.1	7tmA_FMRFamide_R-like	40..328	CDD:320109	78/340 (23%)
		TM helix 1	42..66	CDD:320109	9/23 (39%)
		TM helix 2	75..97	CDD:320109	6/21 (29%)
		TM helix 3	115..137	CDD:320109	5/22 (23%)
		TM helix 4	161..177	CDD:320109	2/15 (13%)
		TM helix 5	208..231	CDD:320109	4/22 (18%)
		TM helix 6	257..282	CDD:320109	12/24 (50%)
		TM helix 7	296..321	CDD:320109	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.880