DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13229 and egl-6

DIOPT Version :9

Sequence 1:	NP_001260880.1	Gene:	CG13229 / 36168	FlyBaseID:	FBgn0033579	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001257033.1	Gene:	egl-6 / 183513	WormBaseID:	WBGene00001175	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	112/379 - (29%)
Similarity:	185/379 - (48%)	Gaps:	51/379 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NWLRAYNSIHGYVSLMICIFGTIANILNIMVLTRKEMAKTPINNILKWLAVAD--------MFVM 123
            ::|:.|:.||..:|:.|||||..:|:.||:|||||.| :||||.:|..|::|.        ::::
Worm    27 SFLQYYDEIHIPLSISICIFGAASNVFNIIVLTRKRM-RTPINILLTGLSIAQWLLATNYFLYLL 90

  Fly   124 LEYIPYTSYQYIYMGPGEKDLSYTWAVCLLVHMHFTQILHTISIGLTVTLAVWRYVAIRHPNGGC 188
            |||..|...|.::   .|....|.:     .:::...:.|||:...|:.:||:||.|::.|..
Worm    91 LEYYRYQCVQLLW---SEAFTRYRF-----FNVNLNTVFHTIAFTTTIVVAVFRYCALKFPIQ-- 145

  Fly   189 ANFLLAHSREAI---LLPFILSPILCLPTYFVFQVR------ETYDVDKVNSEAMYHVYFDKDSV 244
            ||..:...:.||   ::.:|:.||:.||.:|:.:|:      ..||:.......:|.:.:.:..:
Worm   146 ANRFIYKCQPAIAANVIIWIIIPIISLPLFFISEVKIVARDHVAYDLQCEMEGPLYDLSYQESPL 210

  Fly   245 LYRFNFWIHSVLIKLLPCGILIVISAVLMHVLCEASRRRLKLRDYNNPAKYAIQLNLNETKSKKP 309
            |....||...::.||||..||.::...|:..|....|||...       |.....|:.....:|.
Worm   211 LVSAVFWAFGIVFKLLPSLILSILLIALIRSLKSVERRRKNW-------KRTQGANICTNSERKA 268

  Fly   310 PRCDRRNDRTTLLLVAVLVLFLITEFPQGLLGLLSGVMEKCFFAHCYPPFGELMDLLALINAAVG 374
            .|......|||.:||.:|:|.::.|.|.|:|.|...:..:.|....|.|.|.||::|.|:.::|.
Worm   269 KRKLTTRPRTTRMLVIILLLCVMVELPMGILNLCVAIYGEEFGNRYYDPVGNLMEMLTLLYSSVS 333

  Fly   375 FVLYGLMSKQFRTTFRSLFM----------------KRHFGSTEMTRLTRVTTT 412
            ||||..||.::.:|||:||.                .||...|:..|...:..|
Worm   334 FVLYCTMSNEYLSTFRALFFPWTRKNSLRGTRRSWNHRHDDETKSPRTFLINRT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13229	NP_001260880.1	7tm_4	78..393	CDD:304433	101/331 (31%)
egl-6	NP_001257033.1	7tmA_FMRFamide_R-like	35..348	CDD:320109	100/330 (30%)
		TM helix 1	35..61	CDD:320109	14/25 (56%)
		TM helix 2	67..92	CDD:320109	5/24 (21%)
		TM helix 3	111..141	CDD:320109	9/34 (26%)
		TM helix 4	154..174	CDD:320109	6/19 (32%)
		TM helix 5	212..237	CDD:320109	8/24 (33%)
		TM helix 6	273..303	CDD:320109	12/29 (41%)
		TM helix 7	316..341	CDD:320109	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I2730
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46273
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.110