DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13229 and dmsr-7

DIOPT Version :9

Sequence 1:	NP_001260880.1	Gene:	CG13229 / 36168	FlyBaseID:	FBgn0033579	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_504431.2	Gene:	dmsr-7 / 178922	WormBaseID:	WBGene00016428	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	390	Identity:	110/390 - (28%)
Similarity:	191/390 - (48%)	Gaps:	54/390 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PQVDECQGYCQGEIYNWLRAYNSIHGYVSLMICIFGTIANILNIMVLTRKEMAKTPINNILKWLA 116
            |..:..|.:.: ::.::.|.|..|||||.::||:||...|.:::.||:|..|..:.:|.||..:|
Worm    12 PNSNSTQAFLR-KLAHFQRWYQPIHGYVCVLICVFGIFTNFVHVAVLSRPNMRNSAVNCILTAVA 75

  Fly   117 VADMFVMLEYIPYTSYQYIYMGPG-EKDLSYTWAVCLLVHMHFTQILHTISIGLTVTLAVWRYVA 180
            |.|:..|..|:.|..:..:..... ....:::|...||.|:..:..|||.|:.|.|.:|..|.:.
Worm    76 VCDIGTMASYLIYIIHFVLRRNNSCTPTFTHSWLQFLLWHVVLSITLHTTSLWLAVAMAFIRRMT 140

  Fly   181 IR---------HPNGGCANFLLAHSREAILLPFILSPILCLPTYFVFQVRETYDVD--------- 227
            :|         .|.         .:.:..|..:::..:||:|...|.::......|
Worm   141 LRVTALNSQWQRPK---------FAWKLCLGIYMVVFVLCIPNMLVHEIARVEGNDWRPGKTCQK 196

  Fly   228 --KVNSEAMY-----HVYFDKDSVLYRFNFWIHSVLIKLLPCGILIVISAVLMHVLCEASRRRLK 285
              ...||.:|     |.....:..|:::|.|:..:|.|::||.:||.:|..|:..:.:|.:.|.|
Worm   197 FASNYSEPVYTFMVSHAATINNCRLFKWNIWMIGILFKIIPCILLIFLSFGLVSKIRDAEKHRRK 261

  Fly   286 LRDYNNPAKYAIQLNLNETKSKKPPRCDRRNDRTTLLLVAVLVLFLITEFPQGLLGLLSGVMEKC 350
            |....:.|         .|.||...:.:..:|||||:||.:|::|||||||||::.:|..:....
Worm   262 LTSVPSNA---------STDSKPLKKKNGTSDRTTLMLVVILLVFLITEFPQGIISILCAIFTTD 317

  Fly   351 FFAHCYPPFGELMDLLALINAAVGFVLYGLMSKQFRTTF---------RSLFMKRHFGSTEMTRL 406
            ...:.|...|:::|||:|:|::|.||||.:||.::|.||         ..|:..|....||:::|
Worm   318 VHRYLYFYIGDVLDLLSLVNSSVNFVLYCVMSSRYRQTFWEVIIPSWACGLWTTRRGSPTELSQL 382

Fly 407 406
Worm 383 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13229	NP_001260880.1	7tm_4	78..393	CDD:304433	98/349 (28%)
dmsr-7	NP_504431.2	7tmA_FMRFamide_R-like	33..356	CDD:320109	99/340 (29%)
		TM helix 1	35..59	CDD:320109	11/23 (48%)
		TM helix 2	68..90	CDD:320109	9/21 (43%)
		TM helix 3	113..135	CDD:320109	8/21 (38%)
		TM helix 4	158..174	CDD:320109	3/15 (20%)
		TM helix 5	223..246	CDD:320109	8/22 (36%)
		TM helix 6	284..309	CDD:320109	17/24 (71%)
		TM helix 7	324..349	CDD:320109	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14331
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46273
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X861
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.980