DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and ifit14

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001287802.1	Gene:	ifit14 / 794786	ZFINID:	ZDB-GENE-131120-20	Length:	433	Species:	Danio rerio

Alignment Length:	351	Identity:	69/351 - (19%)
Similarity:	131/351 - (37%)	Gaps:	109/351 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EPGTEQINCNGRLIELPTLEVVRPAPKMPSDANIDWLLHIYFTRREFTRCRRLIE--RELNR-H- 63
            |.|||:             ..||   .:.:.||:.|   :||...|..:.|..:|  .||.| |
Zfish    78 EQGTEE-------------TAVR---LLVNKANLAW---VYFYLGELEKSRGYLEELEELQRIHP 123

  Fly    64 ------LNPEYLYFVQG-----LIDREEGNHIEALRHLQKSAELNPRNIETYKEIGRTL------ 111
                  |:||    |.|     |:...:....:|:.:.:.:.|..|...|.:|.:..::
Zfish   124 APPGCPLHPE----VSGEKGWTLVKFNKSKKSQAIGYFKMALEAEPERKEWHKGLAISMSKACLW 184

  Fly   112 ---------YIMGR------------FSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQ 155
                     .|:.:            |.|:|.|.::.|.:....|.||.    .||.::.:|.:.
Zfish   185 YKCTPEQKAEILEKVKTAAEIDPNDLFLQSLYVLKKFEVQGENVDEEIQ----SLLKKSISTANL 245

  Fly   156 KDVASQQQDEARTYFELAVQSGRKLESYVRLAELY---------------------RKDKQ---- 195
            ..:     :....||: .:..||.:|...|:.|::                     ::|.:
Zfish   246 VGL-----NYIIEYFK-GISYGRAIEEVQRVREIFPSSSTLLKILANLYKWKVFSMKEDSRERRI 304

  Fly   196 -YQKAIEILENCLHLTPENSEVLIEISVLYLKINETQKAHDRLAEVVSIERKCSP--KGLLAFGA 257
             .||:||:.|..:...|:..:...:::.|:...:.|::|.:...:::|.:....|  :.||.:..
Zfish   305 WVQKSIELFEEVVRHYPDCVKGRSDLASLHRYAHNTERAEEIYQQLLSEDHTLPPHSQQLLYYSY 369

  Fly   258 IL------QSRNDIDGALSKYSQIAN 277
            ..      |||:.....|.|.::|.|
Zfish   370 ACYVHHTGQSRDKSINFLMKAAEIKN 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	17/102 (17%)
		TPR repeat	68..95	CDD:276809	4/31 (13%)
		TPR_12	97..175	CDD:290160	17/104 (16%)
		TPR repeat	100..130	CDD:276809	8/56 (14%)
		TPR repeat	136..175	CDD:276809	7/38 (18%)
		TPR repeat	179..209	CDD:276809	9/55 (16%)
		TPR_19	190..254	CDD:291240	13/91 (14%)
		TPR repeat	214..242	CDD:276809	3/27 (11%)
		TPR repeat	249..277	CDD:276809	9/35 (26%)
		TPR_11	283..348	CDD:290150
		TPR repeat	283..311	CDD:276809
		TPR repeat	316..346	CDD:276809
		TPR repeat	351..377	CDD:276809
ifit14	NP_001287802.1	TPR_12	47..120	CDD:290160	16/60 (27%)
		TPR repeat	248..272	CDD:276809	6/29 (21%)
		TPR repeat	277..319	CDD:276809	6/41 (15%)
		TPR repeat	324..352	CDD:276809	3/27 (11%)
		TPR repeat	358..392	CDD:276809	8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900