DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BBS4 and SPAG1

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_016869243.1	Gene:	SPAG1 / 6674	HGNCID:	11212	Length:	961	Species:	Homo sapiens

Alignment Length:	430	Identity:	95/430 - (22%)
Similarity:	163/430 - (37%)	Gaps:	86/430 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 NPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLY--RAATTQSQKDVA 159
            ||..:   |..|..|:..|:|::|.|.:..|.........||...| .:||  |||....:.:.:
Human   479 NPAGL---KSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDL-SILYSNRAACYLKEGNCS 539

  Fly   160 SQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAI----EILE-NC-LHLTPEN----S 214
            ...||..|. .||...|.:.|   :|.|..|...:||.||.    .:|: :| |.|..::    |
Human   540 GCIQDCNRA-LELHPFSMKPL---LRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLS 600

  Fly   215 EVLIEIS----------VLYLKINETQKAHDRLAEVVSIERKCS----PKGLL---AFGAILQSR 262
            .:|:|:.          :..:..:...:|.....|::|.:...|    .:|:.   .|.|:.:..
Human   601 RILMELDGPNWREKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKEEG 665

  Fly   263 N------DIDGALSKYSQIANAEPEIAELWNNIGLCFFKKQKFIVAISSLRKSVWLSPLNYNALY 321
            |      :...||||||:......:...::.|..||:.|..:|..|.....:::.|:..|..|.|
Human   666 NQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFY 730

  Fly   322 NLSLIYIASEQYASAFHTLAAAINLRKDNAECYM-------LLGLC-----------LRKLD--- 365
            ..:|.:...:.|..:...|...|.|.....|..|       ||.|.           .||::
Human   731 RRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAPFNKEKERRKIEIQE 795

  Fly   366 -------------DMENAFVALERASSMATGQQGAGRNPLVVLNFALFCYETGRL--ALSTEQYN 415
                         ::....:|.|:....:...:...:.|:...|.|   ||.|::  ||||.:..
Human   796 VNEGKEEPGRPAGEVSMGCLASEKGGKSSRSPEDPEKLPIAKPNNA---YEFGQIINALSTRKDK 857

  Fly   416 RFMSQAQDLLLPTEY-KFQATKLKS---LLRISNQGNGIL 451
            ...:....:..|.:. .|.:.||:.   ||.|.:..|.::
Human   858 EACAHLLAITAPKDLPMFLSNKLEGDTFLLLIQSLKNNLI 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	9/29 (31%)
		TPR repeat	68..95	CDD:276809
		TPR_12	97..175	CDD:290160	23/79 (29%)
		TPR repeat	100..130	CDD:276809	8/29 (28%)
		TPR repeat	136..175	CDD:276809	13/40 (33%)
		TPR repeat	179..209	CDD:276809	11/35 (31%)
		TPR_19	190..254	CDD:291240	17/90 (19%)
		TPR repeat	214..242	CDD:276809	5/37 (14%)
		TPR repeat	249..277	CDD:276809	10/36 (28%)
		TPR_11	283..348	CDD:290150	15/64 (23%)
		TPR repeat	283..311	CDD:276809	6/27 (22%)
		TPR repeat	316..346	CDD:276809	7/29 (24%)
		TPR repeat	351..377	CDD:276809	9/59 (15%)
SPAG1	XP_016869243.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900