DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and ifit8

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001032654.1	Gene:	ifit8 / 641567	ZFINID:	ZDB-GENE-051127-17	Length:	429	Species:	Danio rerio

Alignment Length:	342	Identity:	69/342 - (20%)
Similarity:	123/342 - (35%)	Gaps:	108/342 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LIERELNRHLNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNPRN----IETYKEIGRTLYIMG 115
            |.:||||      :|.|::.|    :|.:.|||::|..:.|.:|.:    |.||   |...::..
Zfish    45 LKQRELN------FLAFIKHL----QGFNDEALKNLLLAKEEHPNDDRTVIVTY---GNLAWVHS 96

  Fly   116 RFSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVASQQQDEARTYFELAVQSGRKL 180
            ..|.|    .|||....:        :.|:|....|.:..::|.|::......:.:
Zfish    97 FLSNA----TEAEAYIEK--------INEILRAFPTPELHREVLSEKAWSLLKFSK--------- 140

  Fly   181 ESYVRLAELYRK-------DK-------------------QYQK-------AIEILENCLHLTPE 212
            :||:|..|::.:       ||                   ||.:       |:..|:..|.|.|:
Zfish   141 KSYIRAKEIFLEALQKEPDDKEWNTGLAFSLFRLEGLKIGQYHRVRFEESPAVLQLKKALKLDPD 205

  Fly   213 NSEVLIEISVLYLKINETQKAHDRLAEVVSIERKCSPKGL---LAFGAILQSRNDIDGALSKYSQ 274
            |..:|:.:.:...|..:..:|...:.:.:    |.:|..|   |.....::.....|.||....:
Zfish   206 NPMILVYLGLKCYKNIKNSEAWQYMTQAL----KMAPHNLSVVLHVAKFMKKEQCYDRALDVLLE 266

  Fly   275 IANAEPEIA----ELWNN----------------IGLCFFKKQKFIVAISSLRKSVWLSPLNYNA 319
            :....|:.:    |:.||                :|||          :..|.|...|:|.....
Zfish   267 MLKKAPDSSRLHHEVANNYRWKAMQIDDIHNPELLGLC----------VHHLEKGASLNPGYVYP 321

  Fly   320 LYNLSLIYIASEQYASA 336
            ...|:|.|...:|...|
Zfish   322 QLELALRYAELKQAGKA 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	16/67 (24%)
		TPR repeat	68..95	CDD:276809	8/26 (31%)
		TPR_12	97..175	CDD:290160	15/81 (19%)
		TPR repeat	100..130	CDD:276809	9/33 (27%)
		TPR repeat	136..175	CDD:276809	5/38 (13%)
		TPR repeat	179..209	CDD:276809	11/62 (18%)
		TPR_19	190..254	CDD:291240	16/99 (16%)
		TPR repeat	214..242	CDD:276809	3/27 (11%)
		TPR repeat	249..277	CDD:276809	6/30 (20%)
		TPR_11	283..348	CDD:290150	15/74 (20%)
		TPR repeat	283..311	CDD:276809	8/47 (17%)
		TPR repeat	316..346	CDD:276809	5/21 (24%)
		TPR repeat	351..377	CDD:276809
ifit8	NP_001032654.1	TPR_12	50..117	CDD:290160	23/91 (25%)
		TPR repeat	206..236	CDD:276809	4/33 (12%)
		TPR repeat	241..269	CDD:276809	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900