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Protein Alignment BBS4 and BBS4

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_149017.2	Gene:	BBS4 / 585	HGNCID:	969	Length:	519	Species:	Homo sapiens

Alignment Length:	506	Identity:	157/506 - (31%)
Similarity:	261/506 - (51%)	Gaps:	65/506 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RPAPKMPSDANIDWLLHIYFTRREFTRCRRLIERELNRHLN-PEYLYFVQGLIDREEGNHIEALR 88
            :.||:.|.....:||:|:::.|:::..|:.:|:.:|..... .||..:||.||.|.|||..|:|.
Human    24 KKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLE 88

  Fly    89 HLQKSAELNPRNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQ 153
            ..|..|.|:|::.:..|::.|:|:::|:...|:.|:.|| .:.:::|.||.|.|| :.|
Human    89 LFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEA-AKLNQKDWEISHNLG-VCY------ 145

  Fly   154 SQKDVASQQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHLTPENSEVLI 218
                :..:|.::|:.....|:...|...:|:.|.:::..:....||||:.:..:..:|||:|:|.
Human   146 ----IYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLT 206

  Fly   219 EISVLYLKINETQKAHDRLAEVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIA 283
            .:.:|||::...|||.:.|...::.: ..:.|.:||.|:::|:..|.|.||:||..:|.|.||..
Human   207 TLGLLYLQLGIYQKAFEHLGNALTYD-PTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESP 270

  Fly   284 ELWNNIGLCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRK 348
            .||||||:|||.|:|::.|||.|:::.:|:|.::..||||.|:::..:|||||||.|:||||.:.
Human   271 PLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQP 335

  Fly   349 DNAECYMLLGLCLRKLDDMENAFVALERASSMATGQQGAGRNPLVVLNFALFCYETGRLALSTEQ 413
            ...|.||||.:.|..|:|:|||    :||.:.|......  ||||.||:|:..|..|....:..|
Human   336 KMGELYMLLAVALTNLEDIENA----KRAYAEAVHLDKC--NPLVNLNYAVLLYNQGEKKNALAQ 394

  Fly   414 YNR------FMSQAQDLLLPTEYKFQATKLKSLLRI----------------------------- 443
            |..      .:.....|...:|....|.||.:.|::
Human   395 YQEMEKKVSLLKDNSSLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHQTTSTSKPASFQ 459

  Fly   444 ----SNQGNGILLDSA----DMGESDLGHNRATELLPDELPLEVNAVVSQN 486
                |||..|..:.||    .:.....|.::.|:  |..||||....|..:
Human   460 QPLGSNQALGQAMSSAAAYRTLPSGAGGTSQFTK--PPSLPLEPEPAVESS 508

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.