DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and Tmtc1

DIOPT Version :9

Sequence 1:	NP_610636.1	Gene:	BBS4 / 36167	FlyBaseID:	FBgn0033578	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_945318.2	Gene:	Tmtc1 / 387314	MGIID:	3039590	Length:	942	Species:	Mus musculus

Alignment Length:	338	Identity:	69/338 - (20%)
Similarity:	116/338 - (34%)	Gaps:	118/338 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNP------------------------------ 98
            |:..|..|   |:|  .|...:|:.|.|::.:|:|
Mouse   678 LHNNYAVF---LVD--SGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKAEEWYRRAL 737

  Fly    99 ---RNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVAS 160
               |..|....:|...|..||..:||.|:|||......| .|:...|.::|.....|:..:.:.|
Mouse   738 KVARTAEVLSPLGALYYNTGRHKEALEVYREAVSLQPSQ-RELRLALAQVLAVMGQTKEAEKITS 801

  Fly   161 QQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHLTPENSEVLIEISVLYL 225
                      .:..:..|.||.|..|:.::.|.:.:.||:|.:|..|.|.|::.:|:.|:  .:.
Mouse   802 ----------HIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKALQLKPKDPKVISEL--FFT 854

  Fly   226 KINETQKAHDRLAEVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIG 290
            |.|:                             |:.:|.:|.|...|......:|:.|:.|.|:|
Mouse   855 KGNQ-----------------------------LREQNLLDKAFESYEAAVTLDPDQAQAWMNMG 890

  Fly   291 LCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYM 355
                       .|..::.|                 |:::..|......|.....|.|:|
Mouse   891 -----------GIRHIQGS-----------------YVSARAYYERALKLVPDSKLLKEN----- 922

  Fly   356 LLGLCLRKLDDME 368
                 |.|||.:|
Mouse   923 -----LAKLDRLE 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR_12	63..127	CDD:290160	21/95 (22%)
		TPR repeat	68..95	CDD:276809	8/26 (31%)
		TPR_12	97..175	CDD:290160	19/110 (17%)
		TPR repeat	100..130	CDD:276809	11/29 (38%)
		TPR repeat	136..175	CDD:276809	5/38 (13%)
		TPR repeat	179..209	CDD:276809	10/29 (34%)
		TPR_19	190..254	CDD:291240	12/63 (19%)
		TPR repeat	214..242	CDD:276809	4/27 (15%)
		TPR repeat	249..277	CDD:276809	5/27 (19%)
		TPR_11	283..348	CDD:290150	10/64 (16%)
		TPR repeat	283..311	CDD:276809	6/27 (22%)
		TPR repeat	316..346	CDD:276809	3/29 (10%)
		TPR repeat	351..377	CDD:276809	5/18 (28%)
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..285
		DUF1736	351..425	CDD:285594
		TPR_11	542..605	CDD:290150
		TPR 1	543..576
		TPR_2	543..576	CDD:285020
		TPR repeat	543..571	CDD:276809
		TPR repeat	576..603	CDD:276809
		TPR 2	577..607
		TPR	577..607	CDD:197478
		TPR_17	596..628	CDD:290167
		TPR 3	608..641
		TPR repeat	608..636	CDD:276809
		TPR	621..940	CDD:223533	69/338 (20%)
		TPR 4	642..675
		TPR repeat	642..670	CDD:276809
		TPR repeat	675..705	CDD:276809	9/31 (29%)
		TPR 5	676..709		11/35 (31%)
		TPR 6	710..742		0/31 (0%)
		TPR repeat	710..738	CDD:276809	0/27 (0%)
		TPR_7	715..744	CDD:289919	1/28 (4%)
		TPR 7	743..776		11/32 (34%)
		TPR repeat	743..771	CDD:276809	11/27 (41%)
		TPR_14	749..786	CDD:290164	13/37 (35%)
		TPR repeat	776..806	CDD:276809	6/40 (15%)
		TPR 8	811..844		12/32 (38%)
		TPR repeat	812..839	CDD:276809	8/26 (31%)
		TPR repeat	844..878	CDD:276809	9/64 (14%)
		TPR 9	849..882		9/63 (14%)
		TPR 10	883..916		9/60 (15%)
		TPR_1	883..915	CDD:278916	9/59 (15%)
		TPR repeat	883..911	CDD:276809	8/55 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810