Protein Alignment BBS4 and Tmtc1

DIOPT Version :10

• Sequence 1: NP_610636.1
• Gene: BBS4 / 36167
• FlyBaseID: FBgn0033578
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_945318.2
• Gene: Tmtc1 / 387314
• MGIID: 3039590
• Length: 942
• Species: Mus musculus
• Alignment Length: 338
• Identity: 69/338 - (20%)
• Similarity: 116/338 - (34%)
• Gaps: 118/338 - (34%)

  Fly    64 LNPEYLYFVQGLIDREEGNHIEALRHLQKSAELNP------------------------------ 98
            |:..|..|   |:|  .|...:|:.|.|::.:|:|
Mouse   678 LHNNYAVF---LVD--SGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKAEEWYRRAL 737

  Fly    99 ---RNIETYKEIGRTLYIMGRFSQALGVFREAEQRSSRQDHEIYHYLGELLYRAATTQSQKDVAS 160
               |..|....:|...|..||..:||.|:|||......| .|:...|.::|.....|:..:.:.|
Mouse   738 KVARTAEVLSPLGALYYNTGRHKEALEVYREAVSLQPSQ-RELRLALAQVLAVMGQTKEAEKITS 801

  Fly   161 QQQDEARTYFELAVQSGRKLESYVRLAELYRKDKQYQKAIEILENCLHLTPENSEVLIEISVLYL 225
                      .:..:..|.||.|..|:.::.|.:.:.||:|.:|..|.|.|::.:|:.|:  .:.
Mouse   802 ----------HIVSEEPRCLECYRLLSAIHSKQEHHGKALEAIEKALQLKPKDPKVISEL--FFT 854

  Fly   226 KINETQKAHDRLAEVVSIERKCSPKGLLAFGAILQSRNDIDGALSKYSQIANAEPEIAELWNNIG 290
            |.|:                             |:.:|.:|.|...|......:|:.|:.|.|:|
Mouse   855 KGNQ-----------------------------LREQNLLDKAFESYEAAVTLDPDQAQAWMNMG 890

  Fly   291 LCFFKKQKFIVAISSLRKSVWLSPLNYNALYNLSLIYIASEQYASAFHTLAAAINLRKDNAECYM 355
                       .|..::.|                 |:::..|......|.....|.|:|
Mouse   891 -----------GIRHIQGS-----------------YVSARAYYERALKLVPDSKLLKEN----- 922

  Fly   356 LLGLCLRKLDDME 368
                 |.|||.:|
Mouse   923 -----LAKLDRLE 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_610636.1	TPR repeat	68..95	CDD:276809	8/26 (31%)
		LapB	70..347	CDD:442196	59/309 (19%)
		TPR repeat	100..130	CDD:276809	11/29 (38%)
		TPR repeat	136..175	CDD:276809	5/38 (13%)
		TPR repeat	179..209	CDD:276809	10/29 (34%)
		TPR repeat	214..242	CDD:276809	4/27 (15%)
		TPR repeat	249..277	CDD:276809	5/27 (19%)
		BepA	281..423	CDD:443813	17/88 (19%)
		TPR repeat	283..311	CDD:276809	6/27 (22%)
		TPR repeat	316..346	CDD:276809	3/29 (10%)
		TPR repeat	351..377	CDD:276809	5/18 (28%)
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..285
		TMTC_DUF1736	351..425	CDD:462468
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	543..576
		TPR repeat	543..571	CDD:276809
		LapB	547..798	CDD:442196	28/125 (22%)
		TPR repeat	576..603	CDD:276809
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	577..607
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	608..641
		TPR repeat	608..636	CDD:276809
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	642..675
		TPR repeat	642..670	CDD:276809
		TPR repeat	675..705	CDD:276809	9/31 (29%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	676..709		11/35 (31%)
		LapB	683..938	CDD:442196	67/333 (20%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	710..742		0/31 (0%)
		TPR repeat	710..738	CDD:276809	0/27 (0%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	743..776		11/32 (34%)
		TPR repeat	743..771	CDD:276809	11/27 (41%)
		TPR repeat	776..806	CDD:276809	6/40 (15%)
		TPR 8. /evidence=ECO:0000255	777..810		5/42 (12%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	811..844		12/32 (38%)
		TPR repeat	812..839	CDD:276809	8/26 (31%)
		TPR repeat	844..878	CDD:276809	9/64 (14%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	849..882		9/63 (14%)
		TPR 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	883..916		9/60 (15%)
		TPR repeat	883..911	CDD:276809	8/55 (15%)